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    Öğe
    DECREASED HEART RATE VARIABILITY IN SICKLE CELL ANEMIA AS EFFECT OF PULMONARY ARTERIAL HYPERTENSION
    (Russian Heart Failure Soc, 2019) Akgul, F.; Batyraliev, T. A.; Fettser, D., V; Seyfeli, E.; Arystan, A. G.; Seydaliyeva, T.; Gali, E.
    Decreased heart rate variability (HRV) is associated with increased mortality risk in various diseases. The objective of this investigation: to study HRV in patients with sickle cell anemia (SCA) and to assess the effect of pulmonary arterial hypertension (PAH) on HRV in these patients. Materials and methods. HRV registration and Doppler echocardiographic assessment of systolic pulmonary arterial pressure (PAP) was carried out in 61 stable patients with SCA and 24 healthy subjects. Results. Low frequency power (LFP) and high frequency power (HFP) were decreased in SCA patients compared to healthy subjects. Among SCA patients, PAH patients had lower LFP and HFP than patients without PAH. In SCA patients, systolic PAP showed significant negative correlation with LFP and HFP. Conclusion. HRV is significantly decreased in SCA patients, especially in those with PAH. HRV may be particularly useful in early detection of PAH patients who may have worse prognosis and higher mortality risk.
  • Küçük Resim
    Öğe
    A randomized controlled study evaluating the effects of the temperature of insufflated CO2 on core body temperature and blood gases (an experimental study)
    (Springer, 2007) Bashirov, E.; Cetiner, S.; Emre, M.; Seydaliyeva, T.; Alic, V.; Daglioglu, K.; Ozalevli, M.
    Background: Heated carbon dioxide (CO2) was used for pneumoperitoneum (Pp) to prevent hypothermia. This study aimed to investigate the relationship between the temperature of the insuffated CO2 and blood gases together with the core body temperature (CBT). Methods: A prospective controlled study was performed with 24 pigs weighing approximately 20 kg randomized into four groups of 6 pigs each. A pneumoperitoneum at 12 mmHg of pressure was applied for 60 min with the pig under general anesthesia. The CO2 temperature was 22 degrees C in group 1, 37 degrees C in group 2, and 7 degrees C in group 3. In the sham'' group, pneumoperitoneum was not applied. Arterial blood pH and partial pressure of CO2 (PaCO2) were analyzed before insuffation, every 15 min during the pneumoperitoneum, and 15 min after the desuffation. The CBT was recorded before the insuffation, every 20 min during pneumoperitoneum, and 20 min after the desuffation. Blood gas analyses and CBT records for the sham'' group were performed at the same intervals. Results: Arterial blood pH gradually decreased during pneumoperitoneum. At the 60th minute of pneumoperitoneum, a minimum decrease in arterial blood pH (0.04; p = 0.027) and a minimum increase in PaCO2 (3.67; p = 0.027) were recorded in group 3, whereas a maximum decrease in arterial blood pH (0.18; p = 0.027) and a maximum increase in PaCO2 (17.17; p = 0.027) were recorded in group 2. There was a significant negative correlation between PaCO2 and arterial blood pH in all the groups (r = -0.993; p < 0.01). The mean values of CBT decreases were statistically significant in all the groups: group 1 (p = 0.023), group 2 (p = 0.026), group 3 (p = 0.026), and sham'' group (p = 0.024). Conclusions: The changes in PaCO2 were directly proportional and the changes in pH contrarily proportional to the temperature of the insuffated CO2. Significant differences in CBT decreases were found between the groups receiving heated gas and room temperature gas and the groups receiving heated gas and gas below room temperature.