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    Comparison of triptans, NSAID and combination in migraine attack treatment
    (Kare Publ, 2016) Duman, Taskin; Dede, Hava Ozlem; Seydaoglu, Gulsah
    Objectives: Headache during migraine attack may recur during a single attack. The present study evaluated efficacy of both individual and combined use of agents from nonsteroidal anti-inflammatory drug (NSAID) and triptan groups widely used in treatment of migraine attacks. Methods: A total of 201 attacks in 67 migraine patients were evaluated. Patients were divided into 3 study groups: those receiving rizatriptan 10mg, tenoxicam 20 mg, and rizatriptan + tenoxicam (combination). Patients evaluated severity of headache based on visual analogue scale (VAS) at moment of drug delivery, after 30 minutes, and after 1, 2, 4, 8 and 24 hours. Attacks were evaluated separately for each treatment alternative, and results were also compared. Results: VAS values were the same at onset of attack, but were lower in rizatriptan and combination groups than in tenoxicam group at 30 minutes and onward. VAS score was above 4 at 60 minutes in tenoxicam group and mean VAS value in this group was found to be significantly higher than values in rizatriptan and combined groups. At 24 hours, VAS scores were similar in combination and tenoxicam groups, while rizatriptan group had higher mean VAS score than the other 2 groups. Conclusion: When single drug use fails to provide adequate control, combined use of a rapid-acting triptan and a long-acting NSAID appears to be a suitable treatment option.
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    Öğe
    Correlation of sleep disorder and Parkinson's disease severity in Turkish patients
    (Riyadh Armed Forces Hospital, 2009) Okuyucu, Esra E.; Duman, Taskin; Melek, Ismet M.; Seydaoglu, Gulsah
    [Abstract Not Available]
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    Sleep changes during prophylactic treatment of migraine
    (Wolters Kluwer Medknow Publications, 2015) Duman, Taskin; Dede, Ozlem H.; Uluduz, Derya; Seydaoglu, Gulsah; Okuyucu, Esra; Melek, Ismet
    Aims: To assess sleep quality in patients with primary headaches before and after prophylactic treatment using a validated sleep-screening instrument. Materials and Methods: A total of 147 patients, including 63 tension type headache (TTH) and 84 migraine patients were included. Patients were examined in terms of frequency and severity of headaches and sleep quality before and 12 weeks after prophylactic treatment with either propranolol or amitriptyline. Results: Baseline Visual Analogue Score (VAS) in migraine patients was 7.99 +/- 1.39 compared with 6.86 +/- 1.50 in TTH group (P < 0.001). VAS score after the first month of treatment was 6.08 +/- 1.88 in migraine patients and 5.40 +/- 1.61 in TTH (P = 0.023). VAS scores decreased after the third month of treatment to 4.32 +/- 2.29 in migraine patients and 4.11 +/- 1.66 in TTH patients (P = 0.344). The decrease was significant for patients treated with amitriptyline but not for those with propranolol. Baseline Pittsburgh Sleep Quality (PSQI) scores were 5.93 +/- 2.43 in migraine patients and 6.71 +/- 2.39 in TTH patients. Poor quality of sleep (PSQI = 6) prior to prophylactic treatment was observed in 61.4% of migraine patients and in 77.7% of TTH patients. Comparison of PSQI scores before and 3 months following treatment showed significantly improved quality of sleep in all treatment groups; the greatest significance was detected in migraine patients with initial PSQI scores of = 6 and treated with amitriptyline (P < 0.001). Conclusions: Increased understanding of routine objective sleep measures in migraine patients is needed to clarify the nature of sleep disturbances associated with primary headaches. This may in turn lead to improvements in headache treatments.