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  • Küçük Resim
    Öğe
    Çocukluk çağında anemi sıklığı
    (2012) Yazıcı, Selçuk; Çelik, Tanju; Seyrek, Kamil
    Amaç: Bu çalışmada Balıkesir ilinde üniversite hastanesine başvuran olgularda anemi sıklığını değerlendirmeyi amaçladık. Yöntemler: Hastanemiz çocuk sağlığı ve hastalıkları polikliniğine başvuran, kronik hastalığı olmayan, 563 olgu hastane kayıtlarından retrospektif olarak anemi sıklığı açısından değerlendirildi. Bulgular: Hastanemize başvuran 563 olgunun 265 (%47,1)’i kız, 298 (%52,9)’i erkekti. Yaş ortalamaları 5,9±4,2 (min 5 yıl, max 18) idi. Hemoglobin değerleri ortalama 12,5±1,2 mg/dl (min 8,3 max 18 mg/dl) idi. Ortalama eritrosit volümü (MCV) 78,9±5,7 fL (min; 56,9 max; 101,9) fL olarak tespit edildi. Kırmızı küre dağılım genişliği (RDW) ortalama %13,9±1,6 (min; %7,3 max; %31,3) olarak tespit edildi. Çalışmaya alınan 563 olgunun 117’sinde (%20,8) anemi bulguları saptandı, hastaların 35 (%6,2)’inde demir eksikliği anemisi tespit edildi. Sonuç: Anemi her yaşta görülmekle birlikte, en sık 2 yaş altı çocuklarda demir eksikliği nedeniyle gözlenmektedir. Aneminin büyüme, gelişme ve kognitif fonksiyonları etkilemesinden dolayı proflaksi ve tedavi için demir takviyesi yapılmadır.
  • Küçük Resim
    Öğe
    Prevalance of anemia among children
    (Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2012) Yazici, Selcuk; Celik, Tanju; Seyrek, Kamil
    Objective: In this study, we aimed to determine the prevalance of anemia among patients at university hospital in Balikesir City. Methods: 563 cases, without any chronic illness, who had been examined at outpatient pediatrics clinic of our hospital were retrospectically evaluated for the prevalence of anemia prevelance by perusing hospital records. Results: 265 (47.1%) of 563 cases who were consulted to our hospital were female and 298 (52.9%) were male. The mean age of the patients was 5.9+/-4.2 (5 mos-18 yrs) years. The mean hemoglobin value was 12.5+/-1.2 mg/dl (8.3-18 mg/dl). Mean corpuscular volume (MCV) was detected as 78.9+/-5.7 fL (56.9-101.9 fL). Mean red cell distrubition width (RDW) was 13.9+/-1.6 % (7.3-31.3%). Signs of anemia were present in 117 (20.8%), and iron deficiency anemia in 35 (6.2%) cases. Conclusion: Although anemia is common at all ages, it is mostly seen in children under two years old, due to iron deficiency. Anemia affects growth, development and cognitive functions. Thus iron supplementation is essential for prophylaxis and treatment.
  • Küçük Resim
    Öğe
    PROTECTIVE EFFECTS OF N-ACETYL CYSTEINE ON OLIGOSACCHARIDE RESIDUES IN THE EXPERIMENTAL LIVER INTOXICATION FORMED BY CARBONTETRACHLORIDE (CCL4) IN RATS
    (Carbone Editore, 2016) Aksit, Dilek; Atici, Yasemin; Aksit, Hasan; Kara, Hatibe; Bildik, Aysegul; Seyrek, Kamil
    Aim: In this study, we aimed to investigate the protective effects of N-acetyl cysteine (NAC) that is known playing an important role in detoxification reactions of biomolecules, on rat liver tissue exposed to carbon tetrachloride (CCl4). Materials and methods: Twenty-eight rats were divided into four groups each containing seven rats: Control groups (Group 1: Olive oil group, Group 2: Olive oil+NAC group) and experimental groups (Group 3: CCl4 group, Group 4: CCl4+NAC group). CCl4 was given in 1 ml/kg doses intraperitoneally (i.p.), NAC was given in 50 mg/kg doses. Oligosaccharide units were detected histochemically using biotin labeled lectins. Results: Histochemically, NAC showed no remarkable effect on the staining intensity of biotin labeled lectins. Liver enzyme activities and plasma protein levels were measured using commercial available kits. Compared to the control group in CCl4 given rats AST, GGT and ALP activities increased significantly (P<0.001), while NAC administration alleviated the toxic effects of CCl4. CCl4 decreased serum albumin concentration significantly (P<0.05), however NAC annihilated negative effect of CCl4 on albumin concentration. The alterations in total protein levels and ALT activities remained insignificant (P>0.05). Conclusion: Our findings indicate that cells may increase their oligosaccharide units to protect themselves from the toxic effects of CCl4 and NAC may support cells to scavenge free radicals induced by CCl4.
  • [ N/A ]
    Öğe
    Protective effects of N-acetyl cysteine on oligosaccharide residues in the experimental liver intoxication formed by carbontetrachloride (CCL4) in rats
    (A. CARBONE Editore, 2016) Aksit, Dilek; Atici, Yasemin; Aksit, Hasan; Kara, Hatibe; Bildik, Aysegul; Seyrek, Kamil
    Aim: In this study, we aimed to investigate the protective effects of N-acetyl cysteine (NAC) that is known playing an important role in detoxification reactions of biomolecules, on rat liver tissue exposed to carbon tetrachloride (CCl4). Materials and methods: Twenty-eight rats were divided into four groups each containing seven rats: Control groups (Group 1: Olive oil group, Group 2: Olive oil+NAC group) and experimental groups (Group 3: CCl4 group, Group 4: CCl4+NAC group). CCl4 was given in 1 ml/kg doses intraperitoneally (i.p.), NAC was given in 50 mg/kg doses. Oligosaccharide units were detected histochemically using biotin labeled lectins. Results: Histochemically, NAC showed no remarkable effect on the staining intensity of biotin labeled lectins. Liver enzyme activities and plasma protein levels were measured using commercial available kits. Compared to the control group in CCl4 given rats AST, GGT and ALP activities increased significantly (P < 0.001), while NAC administration alleviated the toxic effects of CCl4. CCl4 decreased serum albumin concentration significantly (P < 0.05), however NAC annihilated negative effect of CCl4 on albumin concentration. The alterations in total protein levels and ALT activities remained insignificant (P > 0.05). Conclusion: Our findings indicate that cells may increase their oligosaccharide units to protect themselves from the toxic effects of CCl4 and NAC may support cells to scavenge free radicals induced by CCl4.