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    Assessment of the Optic Disc and Retinal Microvasculature by Optical Coherence Tomography Angiography in Patients With Pediatric Migraine
    (Lippincott Williams & Wilkins, 2023) Kurtul, Bengi Ece; Sipal, Cansu; Akbas, Yilmaz
    Background:Migraine, as a chronic neurovascular disease, is known to be a risk factor for retinal and optic nerve head damage. Herein, we aimed to evaluate the optic disc and retinal microvasculature in pediatric migraine (PM) patients using optical coherence tomography angiography (OCTA).Methods:Forty-six eyes of 23 patients with PM without aura (PM group) and 46 eyes of 23 age- and sex-matched healthy subjects (control group) were included in this cross-sectional prospective study. Demographic features and ophthalmological examination including OCTA measurements were evaluated. OCTA was performed with 6- x 6-mm sections for macula and 4.5- x 4.5-mm sections for optic nerve head in all eyes. Foveal retinal thickness (FRT), peripapillary retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of the retina, and optic disc were analyzed and compared between the groups. All measurements of the PM patients were taken in the attack-free period.Results:The mean ages of the PM group and control group were 11.17 +/- 3.3 and 11.83 +/- 2.8 years, respectively (P = 0.479). Gender and mean intraocular pressures were similar between the groups. The mean central corneal thickness levels in the PM group were significantly lower than control group, 548.28 +/- 26.3 mu m and 562.04 +/- 24.5 mu m, respectively (P = 0.011). There was no significant difference regarding average and all quadrant RNFL thicknesses, foveal avascular zone and flow areas, deep vessel densities, and optic disc capillary densities between the groups. However, compared with the control group, the PM group showed significant higher values of FRT, and lower values of superficial whole and parafoveal vessel densities (247.28 +/- 15.8 mu m vs 285.93 +/- 11.1, P < 0.001, 51.85 +/- 2.4% vs 50.31 +/- 4.0%, P = 0.02, 55.09 +/- 2.3% vs 53.5 +/- 3.5%, P = 0.01, respectively). Disease duration and attacks/year did not show any significant correlations with OCTA values.Conclusions:PM seems to be associated with lower superficial whole and parafoveal vessel densities because of hypoperfusion and ischemia. OCTA may be suggested for use in follow-up and management of PM patients.