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    Effects of hyaluronan on nitric oxide levels and superoxide dismutase activities in synovial fluid in knee osteoarthritis
    (Springer London Ltd, 2007) Kalacı, Aydıner; Yilmaz, H. Ramazan; Aslan, Bahadir; Soeguet, Sadik; Yanat, Ahmet Nedim; Uz, Efkan
    The aim of the present study was to evaluate the effects of hyaluronan (HA) on nitric oxide (NO) levels and superoxide dismutase (SOD) enzyme activities in synovial fluid (SF) in the treatment of patients with knee osteoarthritis (OA). SF samples were aspirated from OA patients before the commencement of the treatment (n=23) and 6 weeks after they were treated with HA products. NO levels and SOD activities were compared between the pre- and post-treatment of OA patients and of the control group (n=10). SF NO levels were significantly higher in patients with OA before the commencement of the treatment compared with the post-treatment (p < 0.001) and the control groups. The SF SOD activity of patients before the commencement of the treatment was lower than the values in the controls and post-treatment (p < 0.001). There is no significant correlation between SF NO and SOD levels and the radiographic changes of the OA knee according to Kellgren-Lawrence grading (p > 0.05). Also, the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) pain scores and physical function scores were gradually improved. These findings made us think that SF NO was a potent mediator in cartilage damage in OA, whereas SOD was an antioxidant mediator in the same process. Exogenous HA injections might reduce the NO levels and increase SOD activities in synovial fluid. These effects also do not seem to be dependent on the radiographic grading of the OA knee. More comprehensive studies are needed to clarify a possible clinical significance of this topic, and we suggest that this is an important area for further research into new treatment options.
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    Nitric oxide levels and superoxide dismutase enzyme activity in synovial fluid of patients with knee osteoarthritis
    (Turkish Joint Diseases Foundation, 2007) Kalacı, Aydıner; Uz, Efkan; Aslan, Bahadir; Soeguet, Sadik; Oezkan, Cenk; Yanat, Ahmet Nedim
    Objectives: We investigated nitric oxide (NO) levels and superoxide dismutase (SOD) enzyme activity in synovial fluid of patients with primary knee osteoarthritis (OA). Patients and methods: The study included 36 patients (31 females, 5 males; mean age 63 years; range 48 to 88 years) with knee OA according to the diagnosis criteria of American College of Rheumatology. Radiographic severity of OA was assessed according to the Kellgren-Lawrence grading system. Synovial fluid samples were taken by needle aspiration before knee arthroplasty or hyaluronic acid injection and stored at -80 degrees C in Eppendorf tubes. Nitrite and nitrate levels were determined by the spectrophotometric method based on the Griess reaction. Total SOD activity was determined by the spectrophotometric method. The results were compared with those of 10 controls (6 females, 4 males; mean age 49 years; range 26 to 70 years) who clinically and radiographically had normal knees, but underwent arthroscopic examination for knee pain of unknown origin. Results: Compared to controls, NO levels were significantly higher and SOD activity was significantly lower in patients with OA (p < 0.001). No significant differences were found between radiographically graded groups with regard to NO level and SOD activity (p > 0.05). Conclusion: Our data suggest that NO acts as a potent mediator of cartilage damage and SOD as an antioxidant mediator in OA. Further studies are needed to clarify the clinical significance of these parameters.
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    Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid
    (Elsevier Science Bv, 2009) Peker, Erdal; Oktar, Sueleyman; An, Mustafa; Kozan, Ramazan; Dogan, Murat; Cagan, Eren; Soeguet, Sadik
    In the present study, we investigated the effects of valproic acid (VPA) on nitric oxide (NO) level, lipid peroxidation, and antioxidant enzyme activities in 21 epileptic children and 26 healthy controls. The subjects were selected from those who visited for a checkup or medical treatment at the Mustafa Kemal University Research Hospital. Serum levels of NO-2, NO-3, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were analyzed by redox or enzymatic reactions and spectrophotometry. Based on the NO-2 and NO-3 levels, the NO concentration was about 10% higher in VPA group than in the control group (p < 0.001). However, no significant difference was detected for serum MDA, SOD, and CAT levels. It is suggested that NO would play a role in the mechanism of antiepileptic effects by VPA treatment. (c) 2009 Elsevier B.V. All rights reserved.