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Öğe Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia(Funpec-Editora, 2011) Sogut, S.; Yonden, Z.; Kaya, H.; Oktar, S.; Tutanc, M.; Yilmaz, H. R.; Yigit, A.Oxidative stress may be contributory to the pathophysiology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the study. Alanine versus valine polymorphism in the signal peptide of the Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with the restriction enzyme NgoMIV. In the sickle cell anemia patients, the frequency of Val/Val genotype was approximately 1.4-fold lower and that of Ala/Val was 1.3-fold higher compared to the controls. No significant difference in genotype frequencies was found between patients and controls (chi(2) = 4.561, d.f. = 2, P = 0.101). The Val-9 was the most common allele in patient and healthy subjects. No significant difference in allele frequencies was found between patients and controls (chi(2) = 1.496, d.f. = 1, P = 0.221). We conclude that the Mn-SOD gene polymorphism is not associated with sickle cell anemia.Öğe Increased macrophage migration inhibitory factor in Behcet's disease and relation with the disease activity(Wiley, 2009) Serarslan, G.; Sogut, S.; Yonden, Z.; Oksuz, H.; Savas, N.; Yenin, J. Z.; Arpaci, A.[Abstract Not Available]Öğe Is There any Significant Association Between Irritable Bowel Syndrome and Cholelithiasis ?(Aves, 2008) Kuvandik, G.; Helvaci, M. R.; Ozkan, O. V.; Sogut, S.; Kaya, H.; Bozkurt, S.Background: We tried to understand whether or not there is a significant etiopathogenetic relationship between irritable bowel syndrome (IBS) and cholelithiasis. Methods: Consecutive patients with upper abdominal discomfort were included into the study. Routine hematologic and biochemical tests, an abdominal ultrasonography, and a questionnaire for IBS was performed in all cases, and IBS is diagnosed according to Rome II criteria in the absence of red flag symptoms. Cholelithiasis cases were put into one group and age and sex-matched and randomly selected cases without cholelithiasis were put into the other group. Prevalences of smoking, normal weight, overweight, obesity, and IBS were detected in each group and compared in between. Results: One hundred and twenty-one patients with cholelithiasis were diagnosed. Ninety-seven (80.1%) of them were female, and their mean age was 53.4 +/- 9.9 (27-70) years. Interestingly, 92.5% (112 cases) of the cholelithiasis cases had excess weight and obesity was significantly higher in the cholelithiasis group (54.5% vs. 43.8%, p<0.05). Prevalence of IBS was nearly equal in both groups (43.8% in cholelithiasis vs. 42.1% in control cases, p>0.05). Conclusions: IBS probably is a cascade of many physiological events, being initiated with infection, inflammation, psychological disturbances-like stresses and eventually terminated with dysfunctions of genitourinary tract and probably some other systems of body via a low-grade inflammatory process. Although IBS probably has a much more complex mechanism than the current view and a higher prevalence in society, there is not a significant association between IBS and cholelithiasis.Öğe Macrophage migration inhibitory factor in patients with vitiligo and relationship between duration and clinical type of disease(Wiley, 2010) Serarslan, G.; Yonden, Z.; Sogut, S.; Savas, N.; Celik, E.; Arpaci, A.Background. Vitiligo is a disorder of pigmentation characterized by the presence of depigmented skin macules. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity. Aims. To determine serum level of MIF in patients with vitiligo and compare with healthy controls. We also aimed to determine whether there is a relationship between MIF levels and the disease duration, clinical vitiligo and involved body surface area (BSA) in patients with vitiligo. Methods. The study group comprised 30 patients with vitiligo (14 men, 16 women) and 30 healthy controls, matched for age and gender. Blood samples were taken for MIF analysis. Results. The mean serum level of MIF in patients with vitiligo (40.83 +/- 31.66 pg/mL) was significantly higher than that of the control group (21.00 +/- 6.48 pg/mL) (P = 0.002). There was a positive correlation between disease duration and MIF levels (r = 0.601, P < 0.001). Mean MIF level of patients with acral and acrofacial vitiligo (n = 6) was 48.25 +/- 32.02 pg/mL, and of patients generalized vitiligo (n = 18) was 44.46 +/- 35.25 pg/mL. There was no significant difference between these two groups (P > 0.05). However there was a significant difference in MIF levels between patients with localized (20.41 +/- 5.23, n = 5) and acral-acrofacial (P = 0.02) vitiligo and those with generalized (P = 0.006) vitiligo. There was no relationship between BSA and MIF levels. Conclusions. Mean serum MIF level of patients with vitiligo was higher than that of controls, indicating that MIF has a role in the pathogenesis of vitiligo.Öğe The protective role of N-acetylcysteine on cyclosporine A-induced nephrotoxicity in rats(Blackwell Publishing, 2006) Oksuz, H.; Sogut, S.; Koc, A.; Uz, E.; Tamer, C.; Yilmaz, H.; Duru, M.[Abstract Not Available]Öğe Serum malondialdehyde, nitric oxide, glutathione peroxidase and superoxide dismutase status in patients with Behcet's disease(Amer Assoc Clinical Chemistry, 2008) Yonden, Z.; Oksuz, H.; Ozyurt, H.; Atis, O.; Akbas, A.; Cansiz, H.; Sogut, S.[Abstract Not Available]
