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Öğe Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury(Elsevier Science Bv, 2014) Dokuyucu, Recep; Karateke, A.; Gokce, H.; Kurt, R. K.; Ozcan, O.; Ozturk, S.; Tas, Z. A.Objective: To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury. Study design: Forty-eight female Wistar albino rats were separated, at random, into six groups of eight rats. The groups were classified as: sham, torsion, detorsion, detorsion + erdosteine 100 mg/kg, detorsion + alpha lipoic acid (ALA) 100 mg/kg, and detorsion + erdosteine + ALA. The investigators executing the biochemical and histological analyses were blinded to the randomization until the end of the study. Results: The TOS (Total Oxidant Status) and OSI (Oxidative Stress Index) levels are higher in the Torsion and Detorsion groups when compared with the ones in the Sham group (p < 0.05). Strong correlation was found between OSI and total histological score in the sham, torsion and detorsion groups (r = 0.765, p < 0.001). The mean levels of TOS and OSI in the rats that received erdosteine and/or ALA were significantly lower compared with the sham, torsion and detorsion groups (p < 0.05). Mean TOS and mean OSI were lower in the detorsion + erdosteine + ALA group compared with the detorsion + erdosteine and detorsion + ALA groups (p < 0.05). In comparison with the detorsion group, the numbers of primordial follicles (p = 0.006) and primary follicles (p = 0.036) were increased in the groups that received erdosteine and/or ALA. Conclusions: Erdosteine and ALA decreased ischaemia-reperfusion injury in an experimental rat ovarian torsion model; combination treatment had a greater effect than either agent alone. Treatment with erdosteine and/or ALA was found to preserve the loss of reproductive capacity normally observed after ovarian torsion. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Öğe MMP7 and YKL-40 expressions in endometrial endometrioid carcinomas(I R O G Canada, Inc, 2019) Tas, Z. A.; Ozgur, T.; Yaldiz, M.; Dolapcioglu, K.Purpose of investigation: The expressions of YKL-40, MMP-7 and their relations with prognostic factors in endometrioid endometrial carcinomas (EEC) were investigated. Materials and Methods: Paraffin blocks of 50 patients diagnosed with EEC, 27 patients with endometrial hyperplasia, and 26 patients with normal cyclic endometrium were determined and the immunohistochemical staining (IHS) results of MMP-7 and YKL-40 antibodies were obtained. These results were compared with prognostic parameters with statistical evaluation. Results: Score 1 immunostaining was observed in 13 (26%), score 2 in 12 (24%), score 3 in 9 (18%), score 4 in 5 (10%) with MMP-7 in EEC. There was no MMP-7 expression in 9 (% 18) cases in carcinoma group. There was no statistically significant difference in proliferative and secretory phases in normal cycle group (p = 0.527). There was also no statistically significant difference between the non-typical and atypical hyperplasia/EIN cases (p = 0.42). Positive immunostaining was obtained in 15 (58%) of 26 normal cyclic endometrium, in 21 (78%) of 27 hyperplastic endometrium, in 19 (38%) of 50 EEC with YKL-40. The differences of YKL-40 expressions among all the groups were statistically significant (p = 0.01)). MMP-7 and YKL-40 expressions were compared with clinicopathologic parameters in the carcinoma group and found no statistical significant difference (p > 0.05). Conclusion: The present findings were limited but suggested that MMP-7 and YKL-40 might play a role in tumor progression.Öğe Non-infectious erythematous papular and squamous lesions of the skin in our institute, with clinicopathologic correlation(Springer, 2012) Ozgur, T.; Dogramaci, A. C.; Atik, E.; Hakverdi, S.; Yaldiz, M.; Tas, Z. A.[Abstract Not Available]
