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Öğe The Amelorative Role of Thymoquinone on a Rat Model of Letrozole-Induced Polycystic Ovary Syndrome(Wiley-Blackwell, 2015) Dokuyucu, Recep; Ozgur, Tumay; Dogan, Hatice; Tutuk, Okan; Tas, Zeynel Abidin[Abstract Not Available]Öğe Angioleiomyoma of the gingiva: a report of two cases(Korean Acad Oral & Maxillofacial Surgery, 2016) Arpag, Osman Fatih; Damlar, Ibrahim; Kilic, Soydan; Altan, Ahmet; Tas, Zeynel Abidin; Ozgur, TumayLeiomyoma is a type of benign smooth muscle neoplasm that is a common neoplasm of the uterus and gastrointestinal tract but rarely affects the head and neck region and is especially unlikely to affect the oral cavity. The diagnosis of leiomyoma is mainly determined by histopathological studies due to variation in its clinical appearance and symptoms. In the present paper we report two rare cases of gingival angioleiomyoma in the posterior maxilla and mandible. After total excision, hematoxylin-eosin and smooth muscle actin staining confirmed the diagnosis of angioleimyoma.Öğe The Effect of Thymoquinone in Hepatic Ischemia/Reperfusion Rat Model(Wiley-Blackwell, 2015) Caglar, Kerem; Gokce, Hasan; Ozcan, Oguzhan; Tas, Zeynel Abidin; Dogan, Hatice; Agturk, Gokhan; Sefil, Fatih[Abstract Not Available]Öğe Effects of Alpha-Lipoic Acid on TGF-?1 and Urotensin-II Levels in Glucocorticoid-Induced Osteonecrosis in Rats(Kowsar Publ, 2020) Koca, Irfan; Dokuyucu, Recep; Tas, Zeynel Abidin; Gokce, Hasan; Ozcan, OguzhanBackground: Osteonecrosis (ON) is a serious health problem, which dramatically reduces the quality of life. Objectives: In the present study on the rat model of glucocorticoids (GCs) -induced ON, we explored the influence of alpha-lipoic acid on serum levels of TGF-fi1 and urotensin-II (U-II) and on histological alteration with respect to fatty degeneration and osteocyte necrosis. Methods: A total of 32 male Wistar albino rats were equally assigned to four groups, including control, methylprednisolone acetate (MPA), alpha-lipoic acid (ALA), and MPA with ALA (MP1 + ALA). The animals in MPA group subcutaneously received 15 mg/kg/week during 2 weeks, whereas 100 mg/kg/day ALA was intraperitoneally administered to ALA group during 4 weeks. The MPA + ALA group had both treatments with the same doses. ON was confirmed and graded histologically. Lipid peroxidation and DNA damage levels were immunohistochemically assessed in rats' bones. Results: After histopathological examinations, ALA injection attenuated oxidative stress levels through reducing both 8-OHdG-and 4-HNE-positive cells in the femoral head region (P < 0.05). The U-II and TGF-fi1 protein levels significantly decreased after ALA treatment in MPA injected animals (P < 0.05, P < 0.01, respectively). Moreover, there was a strong correlation between U-II and TGF-fi 1 protein levels (P = 0.019, r = 0.884). Conclusions: This study is novel with regard to showing the therapeutic effects of ALA on GC-inducedONin rats as well as the strong correlation between the expression levels of U-II and TGF-fi1 proteins. In this regard, ALAmaybe a therapeutic agent in the treatment of ON patients.Öğe Effects of Alpha-Lipoic Acid on Urotensin II and TGF-?1 on Steroid-induced Osteonecrosis in Rats(Wiley-Blackwell, 2016) Dokuyucu, Recep; Tutuk, Okan; Dogan, Hatice; Bilgic, Nilufer; Tas, Zeynel Abidin; Sefil, Fatih; Gogebakan, Bulent[Abstract Not Available]Öğe Histopathological Effects of Erdosteine in Rat Hepatic Ischemia/Reperfusion Model(Wiley-Blackwell, 2015) Tutuk, Okan; Dokuyucu, Recep; Gokce, Hasan; Ozcan, Oguzhan; Tas, Zeynel Abidin; Dogan, Hatice; Agturk, Gokhan[Abstract Not Available]Öğe Investigation of the Effect of CAPE on Urotensin II and TGF-?1 Levels on Experimental Osteonecrosis Rat Model(Wiley-Blackwell, 2016) Dokuyucu, Recep; Tutuk, Okan; Gogebakan, Bulent; Dogan, Hatice; Bilgic, Nilufer; Tas, Zeynel Abidin; Sefil, Fatih[Abstract Not Available]Öğe Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model(Karger, 2018) Karateke, Atilla; Dokuyucu, Recep; Dogan, Hatice; Ozgur, Tumay; Tas, Zeynel Abidin; Tutuk, Okan; Agturk, GokhanObjective: Polycystic ovary syndrome (PCOS) is a serious endocrine disorder. In the present study, we investigated the therapeutic effects of erdosteine in letrozole-induced PCOS in rats. Methods: Thirty-two Wistar albino female rats were grouped as control group (C), PCOS group (PCOS), PCOS-metformin group (PCOS+MET), and PCOS-erdosteine group (PCOS+Erd). PCOS was induced by administering letrozole; such rats presented with sex hormone disorder, abnormal estrous cycles determined by daily vaginal smear, large cystic follicles, and increasing fasting insulin levels. After induction of PCOS, metformin (500 mg/kg/day) and erdosteine (100 mg/kg/day) were given orally to the treatment groups for 30 days. Serum concentrations of glucose, total cholesterol, low-and high-density lipoprotein, triglyceride, as well as the total oxidant and antioxidant status, oxidative stress index, circulating estrone (E1), estradiol (E2), testosterone, and androstenedione were evaluated. The ovaries were graded histologically. Results: Weights of ovarian tissues (p < 0.05) and the number of atretic follicles (p < 0.001) and cystic follicles (p < 0.01) decreased in the PCOS+Erd group; the corpus luteum number was significantly higher in the PCOS+Erd group (p < 0.01) as compared with the PCOS group. Lipid parameters (total-C, LDL-C, and TG), E1 (estrone), E1/E2 ratio, testosterone, and androstenedione significantly decreased, while HDL-C and E2 (estradiol) significantly increased in the PCOS+Erd group as compared with the PCOS group. Moreover glucose, insulin, and HOMA-IR were reduced with treatment of erdosteine (p > 0.05, p < 0.001, and p < 0.001, respectively). Conclusion: It is suggested that erdosteine may be used in the treatment of PCOS as an alternative to metformin. It appears that our findings might be supported by clinical and molecular studies. (c) 2018 The Author(s) Published by S. Karger AG, BaselÖğe Systemic side effects of locally used oxymetazoline(E-Century Publishing Corp, 2015) Dokuyucu, Recep; Gokce, Hasan; Sahan, Mustafa; Sefil, Fatih; Tas, Zeynel Abidin; Tutuk, Okan; Ozturk, AtakanObjectives: The object of the study is to experimentally investigate the possible systemic side effects of Oxymetazoline including its nasal spray which has been in use for a long time both by the physicians and patients. There is no study in the literature to address the damages of oxymetazoline on the end organ. Materials and methods: The study conducted on 2 groups of rat. Group 1 (n = 8): Control; and Group 2 (n = 8): Oxymetazoline. During 4 week, the control group was applied with 2 drops of saline water on each nasal cavity 3 times a day and the other group was applied with 2 drops of oxymetazoline HCl 3 times a day. At the end of experiment, samples from mandible, parotid and tails of the rats were taken in 10% formalin for histopathological investigations. Results: In histopathological experiments, when compared with the control group, the oxymetazoline group showed significant increase in many of the histopathological parameters (ischemic changes: P = 0.0001; congestion: P = 0.0006; arterial thrombosis: P = Ns; PNL accumulations: P = 0.001; necrosis: P = 0.0001; and ulceration: P = 0.014). The results of histopathologic tests on the samples taken from mandible and parotid gland, in comparison with the control group, showed no significant increase (focal inflammation: P = Ns; and lymphocyte aggregation: P = Ns). Conclusion: Due to the damage that the long-term use of nasal spray including oxymetazoline, it may cause injury on the end organ, which we revealed in our histopathological experiments. We believe that it's essential for the physicians to provide information on the side effects of the medicine to their patients who use for a long term.Öğe The Therapeutic Effects of Erdosteine in a Rat Model of Polycystic Ovary Syndrome(Wiley-Blackwell, 2015) Dokuyucu, Recep; Ozgur, Tumay; Tas, Zeynel Abidin; Tutuk, Okan; Dogan, Hatice; Agturk, Gokhan[Abstract Not Available]Öğe Wound Healing Effect of Centaury Oil Treatment in Diabetic Wound Model(Wiley-Blackwell, 2015) Temel, Metin; Dokuyucu, Recep; Gokce, Hasan; Tas, Zeynel Abidin; Tutuk, Okan; Dogan, Hatice; Agturk, Gokhan[Abstract Not Available]
