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Öğe Comparison of osteoconductive properties of three different ?-tricalcium phosphate graft materials: A pilot histomorphometric study in a pig model(Churchill Livingstone, 2015) Damlar, Ibrahim; Erdogan, Ozgur; Tatli, Ufuk; Arpag, Osman F.; Gormez, Ulas; Ustun, YakupAims: The aim of this study was to compare the de novo bone formation ability and osteoconductive effects of three different beta-tricalcium phosphate (beta-TCP) graft materials. The micro-architectural parameters of the newly formed bone tissues were also compared among the different graft materials. Material and methods: Eight male Swiss domestic pigs were used in the study. Five bony defects were made with a trephine bur. Three of the defects were filled with Cerasorb (R), Kasios (R) and Poresorb (R). The fourth defect was filled with an autogenous bone graft. The last defect remained empty. All subjects were sacrificed after 8 weeks. Results: When compared to a negative control group, significant healing was observed in all the groups except the Cerasorb group. The osteoconductivity of the Poresorb group was better than that of the other groups (p < 0.05). The difference in the osteoconductivity of the Kasios and Cerasorb groups was statistically significant (p < 0.05). Comparison of the micro-architectural properties of newly formed bone tissues retrieved from the defects showed that those filled with Poresorb were the best. Conclusion: beta-TCP materials show different results in terms of the volume and characteristics of new bone formation, although they have a similar chemical structure. (C) 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.Öğe Diagnostic Concordance Characteristics of Oral Cavity Lesions(Hindawi Ltd, 2013) Tatli, Ufuk; Erdogan, OzguR; Uguz, Aysun; Ustun, Yakup; Sertdemir, Yasar; Damlar, IbrahimPurpose. The objective of this study was to evaluate the diagnostic concordance characteristics of oral cavity lesions by comparing the clinical diagnosis of the lesions with the histopathologic diagnosis. Material and Method. A retrospective analysis was conducted on the patients, who were admitted with oral cavity pathology and underwent biopsy procedure between 2007 and 2011. The oral cavity lesions were classified into 6 different groups as odontogenic cysts, nonodontogenic cysts, odontogenic tumors, nonodontogenic tumors, malignant tumors, and precancerous lesions in accordance with the 2005 WHO classification. The diagnoses were also recategorized into 3 groups expressing prognostic implications as benign, precancerous, and malignant. The initial clinical diagnoses were compared with the histopathologic diagnoses. Data were analyzed statistically. Results. A total of 2718 cases were included. Histopathologic diagnosis did not match the clinical diagnosis in 6.7% of the cases. Nonodontogenic tumors and malignant tumors had the highest misdiagnosis rates (11.5% and 9%, resp.), followed by odontogenic tumors (7.7%), precancerous lesions (6.9%), and odontogenic cysts (4.4%). Clinicians were excelled in diagnosis of benign and precancerous lesions in clinical setting. Conclusion. The detailed discordance characteristics for each specific lesion should be considered during oral pathology practice to provide early detection without delay.Öğe Effects of glucosamine-chondroitin combination on synovial fluid IL-1?, IL-6, TNF-? and PGE2 levels in internal derangements of temporomandibular joint(Medicina Oral S L, 2015) Damlar, Ibrahim; Esen, Emin; Tatli, UfukBackground: The aim of the present study was to evaluate the effects of glucosamine-chondroitin sulphate combination on internal derangements of temporomandibular joint in clinical and biochemical manners. Material and Methods: This randomized clinical study included 31 cases reporting joint tenderness, in which disc displacement was detected on MR imaging. In all patients, synovial fluid sampling was performed under local anesthesia. In the study group, the patients were prescribed a combination of 1500 mg glucosamine and 1200 mg chondroitin sulphate, while patients in the control group were only prescribed 50 mg tramadol HCl (twice daily) for pain control. After 8 weeks, synovial fluid sampling was repeated in the same manner. The levels of pain, maximum mouth opening (MMO), synovial fluid IL-1 beta, IL-6, TNF-alpha and PGE(2) measured before and after pharmacological intervention were compared. Results: The reduction in pain levels was significant in both groups. There was no significant difference between two groups in terms of pain reduction. The improvement in MMO was significant in the study group but it was not in the control group. The MMO improvement was significantly higher in the study group compared to the control group. In the study group, significant decrease was observed in PGE(2) level, while the decreases in IL-1 beta, IL-6 and TNF-alpha levels were not significant. In the control group, no significant decrease was observed in any of the inflammatory cytokines after 8 weeks, moreover IL-1 beta and IL-6 levels were increased. Alterations of IL-1 beta and IL-6 levels were significant in study group while TNF-alpha and PGE(2) levels were not, compared to control group. Conclusions: In conclusion, these results might suggest that glucosamine-chondroitin combination significantly increases the MMO and decreases the synovial fluid IL1 beta and IL6 levels in internal derangements of TMJ compared to tramadol. The modifications of synovial fluid TNF-alpha and PGE(2) levels do not reach statistical significance. This combination also provides efficient pain relief in similar level with tramadol, a narcotic analgesic.Öğe Effects of Smoking on Periimplant Health Status and IL-1?, TNF-?, and PGE2 Levels in Periimplant Crevicular Fluid: A Cross-Sectional Study on Well-Maintained Implant Recall Patients(Lippincott Williams & Wilkins, 2013) Tatli, Ufuk; Damlar, Ibrahim; Erdogan, Ozgur; Esen, EminPurpose:The aim of this cross-sectional study was to evaluate the effects of smoking on periimplant health status and inflammatory cytokines interleukin-1, tumor necrosis factor-, and prostaglandin E2 levels in periimplant crevicular fluid (PICF) and to determine their correlation with clinical parameters in well-maintained implant recall patients.Material and Methods:A total of 60 dental implants placed in 60 patients (27 patients were smoker and 33 were nonsmoker) were included in the study. Plaque index, gingival index, probing depth, periimplant bone loss, PICF volume, and biochemical cytokine levels in PICF were determined and analyzed statistically. The correlation between PICF cytokine levels and clinical parameters were also analyzed.Results:All clinical parameters with the exception of plaque scores were significantly higher in the smoker group. Significantly increased levels of cytokines were observed in the smoker group. The correlation between the cytokine levels and clinical parameters were more marked in smokers.Conclusions:Although the implants of the smoker patients seem to be clinically healthy, the results demonstrate that the implants are relatively at risk even if in a well-maintained population.Öğe Efficiency of risk factors causing complication during tooth extraction: A crosssectional study(2012) Tatli, Ufuk; Damlar, Ibrahim; Benlidayi, M. Emre; Üstün, YakupObjective:The aim of this cross-sectional study is to make a contribution to the practical dental education by emphasizing and grading the efficiency of risk factors causing complication during tooth extraction. Materials and Methods:The study consisted of 186 tooth extraction in 108 patients done by intern dental students between 2008 and 2009. The clinical and radiographic data of the patients and complications during extractions were recorded. Chi-square test and Odds Ratio were used in order to analyze the data statistically. Results:The complication rate of intern dental students was 20.43%. The complications were divided into 3 subgroups; crown fracture (%42.1), apical 1/3 root fracture (31.58%), and 2/3 root fracture (%26.32). Root-tip curve, root separation, alveolar bone resorption, crown destruction, restorations, number of roots, and age of the patients increased the complication rate significantly. Gender of the patients and anatomic localization of the teeth did not affect the complication rate significantly. Conclusions:The most potent risk factors were root-tip curve and root separation. The minimum effective risk factors were the number of roots and the age of the patients. In order to prevent complications, pre-operative radiological monitoring of the tooth is mandatory.Öğe Implant treatment of atrophic maxilla following bone augmentation using iliac graft: A case report(2013) Tatli, Ufuk; Damlar, Ibrahim; Benlidayi, M. Emre; Üstün, Yakup; Gürbüz, GözdeAlveolar bone resorption which occurs as a result of teeth extraction or periodontal disease causes functional and esthetic problems. In case of severe jaw-bone atrophy, bone augmentation procedures are becoming necessary prior to implant placement. During the planning of such cases, conebeam computed tomography (CBCT) examination provides detailed qualitative and quantitative data about maxillofacial bones with reduced radiation exposure. This article illustrated the implant treatment of a patient with severe atrophic maxilla following bone augmentation using iliac graft in the light of CBCT examination with 2-year of followup.Öğe Oral Angioleiomyoma of the Lower Lip: A Case Report(Derman Medical Publ, 2013) Damlar, Ibrahim; Kisa, Halil Ibrahim; Tatli, Ufuk; Altan, Ahmet; Hakverdi, SibelLeiomyoma is a benign smooth muscle tumor that occurs most frequently in the uterine myometrium, gastrointestinal tract, skin and lower extremities. Leiomyoma rarely affects the oral cavity. Angioleiomyoma (vascular leiomyoma) is a histological subtype of the leiomyoma. The diagnosis is commonly determined by histopathological studies. This case report shows a 35-year-old male patient with a lesion of the lower lip. After surgical excision, hematoxylin-eosin and smooth muscle actin staining confirmed the diagnosis of angioleiomyoma.Öğe Relationship between voice function and skeletal effects of rapid maxillary expansion(E H Angle Education Research Foundation, Inc, 2018) Bilgic, Fundagul; Damlar, Ibrahim; Surmelioglu, Ozgur; Sozer, Ozlem Akinci; Tatli, UfukObjective: To evaluate the effects of rapid maxillary expansion (RME) on the vocal quality, maxillary central incisors, midpalatal suture, and nasal cavity in patients with maxillary crossbite. Materials and Methods: Coronal CT scans of 30 subjects (14 boys, 16 girls; mean age, 12.01 +/- 0.75) were taken before RME (T0), and at the end of the expansion phase (T1). Voice samples of all patients were recorded with a high-quality condenser microphone (RODE NT2-A) on a desktop computer at T0 and T1. Statistical analyses were performed using a paired-sample t-test. The degree of association between the changes in the voice parameters and nasal width was assessed with Pearson's correlation. Results: RME treatment produced a significant increase in the transverse dimensions of the midpalatal suture and nasal cavity between T0 and T1 (P < .05). The maximum F0 and jitter (%) results were shown to decrease statistically significantly from T0 to T1 (P < .001 and P = .042, respectively). Between T0 and T1, shimmer (%) and shimmer (dB) exhibited statistically significant increases (P = .037 and P = .019, respectively). Conclusions: After RME therapy, voice quality differences were found to be associated with increases in nasal width.Öğe Retrospective Investigation Of the Prevalence of Impacted Teeth in Hatay(Cukurova Univ, Fac Medicine, 2014) Damlar, Ibrahim; Altan, Ahmet; Tatli, Ufuk; Arpag, Osman FatihPurpose: The purpose of this study were to examine localization, the prevalence of impacted permanent teeth and to perform the distributions according to sex and jaws in Hatay population. Material and Methods: In this retrospective study, up to 5227 orthopantomograms of the patients (2865 women, 2362 men) who were referred to Mustafa Kemal University, Faculty of Dentistry, Hatay from December 2010 to June 2013 were examined. Data including the age, gender, localization were evaluated by statistical tests. Results: There were 2187 (% 41,8) patients having impacted teeth. The age of the patients ranged from 18 to 80. Among the impacted teeth, mandibular third molars were the most common (% 64,7), followed by maxillary third molars (% 30,9), maxillary canines (% 3,1), mandibular premolars (% 0,4), mandibular canines (% 0,3), maxillary premolars (% 0,2), maxillary central and lateral incisors (% 0,2), mandibular central and lateral incisors (% 0,1), mandibular first and second molarlars (% 0,07), maxillary first and second molars (% 0,03) Conclusion: In later stages of the people who lives in Hatay's life, due to complications of impacted teeth usually extracted. The impacted teeth were seen without causing any symptoms in a small part of population.Öğe To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model(Univ Sao Paulo Fac Odontologia Bauru, 2018) Arpag, Osman Fatih; Damlar, Ibrahim; Altan, Ahmet; Tatli, Ufuk; Gunay, AhmetAmong the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. Objective: To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with xenograft in rabbit calvarial bone defects. Material and methods: Ten adult male New Zealand rabbits (mean weight 3 kg) were included in the study. Three 6-mm-diameter bicortical cranial defects were created on calvarial bone of all rabbits. These defects were filled as follows: a) xenograft; b) HA+xenograft; c) autograft. One month after the first operation, rabbits were sacrificed. Specimens were evaluated histomorphometrically. Results: Considering multiple comparisons, differences regarding new bone were statistically significant between all groups (p<0.05). The volume of residual graft was significantly decreased in HA group compared to xenograft group (p=0.035). Marrow space, trabecular thickness (TbTh), trabecular width (TbWi), trabecular separation (TbSp), and number of node: number of terminus (NNd:NTm) in the autograft group were significantly better than xenograft and HA groups (p<0.05). However, regarding marrow space, TbTh, TbWi, TbSp, and NNd: NTm values, xenograft and HA groups showed similar results and the difference were not significant (p>0.05). Conclusion: These results support that high molecular weight hyaluronic acid could contribute to the healing of xenograft by improving the percentage of new bone formation and reducing the percentage of residual graft. However, HA did not significantly affect the quality of newly formed bone assessed by microarchitectural parameters.
