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    Long-term Outcomes of Submacular Perfluorocarbon Liquid Removal with Internal Limiting Membrane Peeling and Transretinal Aspiration
    (Georg Thieme Verlag Kg, 2023) Ilhan, Cagri; Ceran, Tugce Horozoglu; Citirik, Mehmet; Teke, Mehmet Yasin
    Background An important complication associated with per-fluorocarbon liquid (PFCL) use during pars plana vitrectomy (PPV) is its retention in the submacular area. The aim of this study was to present the long-t erm outcomes of the surgical method used in this study to remove submacular PFCL and toshed light on the advantages and disadvantages compared to othermethods. Material and Methods This is a retrospective, single-center, observational study. Patients who underwent surgical inter-vention due to submacular PFCL were included in this study. The surgical procedural includes internal limiting membrane (ILM) peeling, transretinal aspiration of submacular PCFL with a 25/27-gauge soft-tipped cannula, then perfluoropropane (C3F8) gas tamponade, and facedown positioning for 5 days. The long-term anatomical and functional outcomes were evaluated with an ophthalmological examination and optical coherence tomography (OCT).Outcomes A total of 15 patients with submacular PFCL were included in this study, and the mean age of the patients was 64.33 +/- 10.36 years (47-83). The localization of submacular PFCL was subfoveal in nine patients (60.00%), non-subfoveal in four patients (26.67%), and both subfoveal and non-sub-foveal in two patients (13.33%). The mean time of submacu-lar PFCL diagnosis was 4.86 +/- 1.02 weeks (2-8) and the mean time of the surgery was 9.80 +/- 1.17 weeks (8-14). Complete removal of submacular PFCL was achieved in all cases (100%) and no significant treatment-associated complications were observed. The mean follow-up time was 37.60 +/- 14.00 months (18-60) and the best-corrected visual acuity was sig-nificantly improved (p = 0.001). At the end of the follow-up time, prominent ellipsoid zone disruption was observed in six patients (40.00 %), while in nine patients (60.00%), there was no prominent ellipsoid zone disruption.Conclusions The surgical procedural for submacular PFCL re-moval is a reasonable option and improves visual acuity in the long term without any significant treatment-associated com-plications.