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    Album spp. toxicosis in small animals: a case report
    (Int Soc Horticultural Science, 2016) Altinok-Yipel, F.; Yipel, M.; Tekeli, I. O.
    Allium spp. (A. cepa [onion], A. ampeloprasum var. porrum L. [leek], A. sativum [garlic] and A. schoenoprasum [chive]) which are used as food and ethnomedical purposes for centuries may cause intoxication in dogs and cats due to contents of organosulfur (disulfide, trisulfide and thiosulfonate) compounds. The material of this case was a 2 years old, 2,5 kg male Yorkshire terrier breed dog which brought to a private veterinary clinic. Anorexia, weakness, depressed and 2 times vomited was included in the history. When the diet information examined in detail, the knowledge of eating meat dish prepared with onion three days ago by dog has been reached. Hemolytic anemia determined according to the hematology results, dark urine and history supported the suspicion of onion intoxication. Symptomatic and supportive (lactated ringer's solution, metoclopramide E, C and B complex vitamins) treatment were performed. It has been observed that the blood values were close to the physiological levels in the hematological examinations that were performed at 2 and 7 days following treatment. Clinical, haematological, biochemical values returned to normal at the 15th day and patient recovered completely. The aim of this case report is point out that frequently consumed human foods like A. cepa (onion) can be poisonous to dogs and cats and should not be allowed to take place in their diets.
  • Küçük Resim
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    Investigation of hepatoprotective effect of some algae species on carbon tetrachloride-induced liver injury in rats
    (Taylor & Francis Ltd, 2020) Altinok-Yipel, F.; Tekeli, I. O.; Ozsoy, S. Y.; Guvenc, M.; Sayin, S.; Yipel, M.
    The aim of this study was to investigate hepatoprotective effect of some algae species such as Spirulina platensis, Chlorella vulgaris, Laminaria japonica, Sargassum sp. on experimental acute hepatotoxicity model that induced with carbon tetrachloride (CCl4) in rats. Algaes at a dose of 200 mg/kg and Silymarin at a dose of 25 mg/kg were orally administered for 7 days followed by CCl4 at a single dose (0.5 ml/kg), at the 8th day to cause experimental acute hepatotoxicity. Levels of biochemical (AST, ALT etc.), lipid peroxidation (MDA), antioxidant (GSH, CAT, GPx) parameters and histopathological examination were carried out to investigate the hepatoprotective effects of algae. In Sp group ALT and ALP levels were significantly decreased compared with CCl4 (p < .05). Histological liver structures of Sp group were similar to the control group. MDA, GPx and CAT levels of Sp and La groups were significantly different compared with CCl4 (p < .05). Based on these results, algae species able to minimise the toxic effects of CCl4 and especially S. platensis could be used in the purpose of protection against chemical-induced hepatotoxicity.