Yazar "Temiz, Muhyittin" seçeneğine göre listele

Listeleniyor 1 - 20 / 52
  • Küçük Resim
    Öğe
    Acute Mesenteric Ischemia: Clinical Experience
    (Aves, 2009) Aslan, Ahmet; Temiz, Muhyittin; Semerci, Ersan; Ozkan, Orhan Veli; Yetim, Ibrahim; Fansa, Iyad; Beyaz, Fikret
    BACKGROUND: Acute mesenteric ischemia (AMI) is a life threatening vascular emergency which requires prompt diagnosis and treatment. The prevention of this cause of high mortality and morbidity depends on early clinical suspicion end timely intervention. In the present study we aimed to analyze the acute mesenteric ischemia cases treated in Mustafa Kemal University Department of General Surgery between January 2004 and December 2008. MATERIAL/METHODS: The clinic records of all the patients who underwent surgical treatment for AMI between January 1, 2004, and December 2008, were retrospectively reviewed. The data from operative records, postoperative complications, mortality, and hospital stay were recorded. RESULTS: The study group included 18 patients. Mean age was 69. There was comorbidity in all patients and cardiac disease and hypertension were the most common ones. The most common laboratory abnormalities were leukocytes, hypoalbuminemia, hyperamylasemia. There was superiorly vascular necrosis in 16 patients; inferior vascular necrosis in one patient. One patient had non occlusive mesenteric ischemia. Segmentery resection was performed to 13 patients. Abdominoperineal resection was performed to the patient with inferior mesenter artery occlusion. We performed duodenotransversostomy on two patients and only laparotomy on two patients. Re-operation was required in 5 patients. Causes of death were multiorgan insufficiency in 7 cases, cardiac death in 2 cases. One patient died due to short intestine syndrome. CONCLUSION: Acute mesenteric ischemia is highly mortal emergency which should always be suspected in elderly patients with cardiac disease suffering from abdominal pain.
  • Küçük Resim
    Öğe
    Addition of Ketamine to Propofol-Alfentanil Anesthesia May Reduce Postoperative Pain in Laparoscopic Cholecystectomy
    (Lippincott Williams & Wilkins, 2013) Karcioglu, Murat; Davarci, Isil; Tuzcu, Kasim; Bozdogan, Yusuf B.; Turhanoglu, Selim; Aydogan, Akin; Temiz, Muhyittin
    Objective: The aim of this study was to assess whether intravenous anesthesia supplemented with ketamine reduces postoperative pain after elective laparoscopic cholecystectomy. Materials and Methods: Forty patients were enrolled and randomized 1: 1 into one of 2 groups: the propofol group (received propofol and alfentanil supplemented with saline) and the ketamine group (received propofol and alfentanil with ketamine). The study was double-blind. The number and amount of the intraoperative additional alfentanil doses were recorded. Pain assessments and cumulative analgesic consumption at postanesthesia care unit (PACU) admission, PACU discharge, postoperative 24th hour, and hospital discharge were recorded. Results: The visual analog scale scores at PACU admission, PACU discharge, postoperative 24th hour, and hospital discharge were significantly lower in the ketamine group than the propofol group. The pain visual analog scale >= 75 at the postoperative 24th hour for the propofol group was also significantly lower (P < 0.035) than that of the ketamine group. The difference in analgesic consumption between groups was statistically significant (P < 0.001). Conclusions: Our study showed that ketamine supplemented with propofol and alfentanil produced better analgesia intraoperatively and postoperatively and decreased analgesic consumption compared with the propofol group after laparoscopic cholecystectomy.
  • Küçük Resim
    Öğe
    Adrenal miyelolipom : Olgu sunumu
    (2008) Hakverdi, Sibel; Görür, Sadık; Temiz, Muhyittin; Akarsu, Bülent; Kiper, Ahmet Namık
    Adrenal miyelolipomlar ender görülen benin tümörlerdir. Sıklıkla boyutları 5 cm’nin altındadır ve belirti vermezler. Burada adrenal miyelolipomlu bir olguyu sunuyor ve yayın bilgileri ışığında değerlendiriyoruz. Sağ kasığa vuran yan ağrısı olan 60 yaşındaki kadın hastada ultrasonografi ve bilgisayarlı tomografi ile sağ adrenal bez yerleşiminde yaklaşık 8 cm boyutta kitle tanımlandı. Ameliyat edilen hastanın materyalinin histopatolojik değerlendirmesinde matür yağ doku ve kemik iliği elemanlarından oluşan tümöre adrenal miyelolipom tanısı kondu. Adrenal bölgede bulunan ve yağ içeriği yüksek olan olgularda ayırıcı tanıda adrenal miyelolipom düşünülmelidir. Kitlenin olguda belirti verip vermemesi ve büyüklüğüne göre tedavi şekli planlanmalıdır.
  • [ N/A ]
    Öğe
    Adrenal myelolipoma: Case report
    (2008) Hakverdi, Sibel; Görür, Sadik; Temiz, Muhyittin; Akarsu, Bülent; Kiper, Ahmet Namik
    Introduction: Adrenal myelolipoma are rare occurring benign tumors. They are generally less than 5cm and may not cause symptoms. We discuss a case with adrenal myelolipoma in the light of literature. A 60 year-old female patient had strait flank pain radiate to inguinal region. In the right adrenal gland, a mass about 8 cm was specified by ultrasonography and computerized tomography imaging. In the hystopathological evaluation of the completely resected mass, it was determined that the mass was composed of mature adipose tissue and hematopoetic elements, and the tumor was described as adrenal myelolipoma. In the cases with masses localized in the adrenal gland, adrenal myelolipoma should be considered. Therapy procedure should be planned according to size of the tumor and the presence of symptoms.
  • [ N/A ]
    Öğe
    ADRENAL MYELOLIPOMA: CASE REPORT
    (Aves, 2008) Hakverdi, Sibel; Gorur, Sadik; Temiz, Muhyittin; Akarsu, Bulent; Kiper, Ahmet Namik
    Adrenal myelolipomas are rare occurring benign tumors. They are generally less than 5cm and may not cause symptoms. We discuss a case with adrenal myelolipoma in the light of literature. A 60 year-old female patient had strait flank pain radiate to inguinal region. In the right adrenal gland, a mass about 8 cm was specified by ultrasonography and computerized tomography imaging. In the hystopathological evaluation of the completely resected mass, it was determined that the mass was composed of mature adipose tissue and hematopoetic elements, and the tumor was described as adrenal myelolipoma. In the cases with masses localized in the adrenal gland, adrenal myelolipoma should be considered. Therapy procedure should be planned according to size of the tumor and the presence of symptoms.
  • Küçük Resim
    Öğe
    Akut mezenter iskemi : Klinik deneyimlerimiz
    (2009) Aslan, Ahmet; Temiz, Muhyittin; Semerci, Ersan; Özkan, Orhan Veli; Yetim, İbrahim; Fansa, İyad; Beyaz, Fikret
    AMAÇ: Akut mezenterik iskemi (AMİ) erken tanı ve tedavi gerektiren hayatı tehdit edici bir vasküler acildir.Günümüzde hala yüksek mortalite ve morbidite ile seyretmekte olan bu hastalığın önlenmesi erken klinik şüphe ve zamanında müdahaleye bağlıdır. Bu çalışmada Mustafa Kemal Üniversitesi Tıp Fakültesi Genel Cerrahi kliniğinde Ocak 2004- Aralık 2008 tarihleri arasında mezenter iskemi tanısıyla takip edilip opere edilen olgularımızın özelliklerini analiz etmeyi amaçladık. GEREÇ-YÖNTEM: Operasyonda AMİ tanısı konulan olgular retrospektif olarak değerlendirildi. Preoperatif, operatif ve postoperatif bulgular SPSS 16.0 programına yüklenerek istatistiki olarak incelendi. BULGULAR: Değerlendirmeye 18 olgu alındı. Yaş ortalaması 69 idi. En sık Kalp hastalıkları ve Hipertansiyon olmak üzere bütün hastalarda ek morbidite mevcuttu. Lökositoz, Hiperglisemi, Hiperamilazemi, Hipoalbüminemi ve kreatinin yüksekliği saptandı. 16 hastada Superior mezenter vasküler nekroz, 1 hastada İnferior mezenter vasküler nekroz ve 1 olguda nonoklüzif mezenter iskemi saptandı. 13 olguya segmenter rezeksiyon uygulanırken, İnferior Mezenter arter embolisi saptanan hasta abdominoperineal rezeksiyon uygulandı. 2 olguya düodenotransversostomi, 2 olguya sadece eksplorasyon uygulandı. 4 olguya tekrar iskemi gelişmesi, 1 olguda insizyonel evisserasyon nedeniyle reoperasyon uygulandı. Toplam 7 olgu postop multiorgan yetmezliğinden ve 2 olgu kardiyak patoloji nedeniyle eksitus olmuştur. SONUÇ: Mezenter iskemi erken tanının çok önemli olduğu halen yüksek mortalite oranları taşıyan, özellikle kardiyak patolojisi olan karın ağrılı hastalarda ayırıcı tanıda mutlaka düşünülmesi gerekli bir hastalıktır.
  • Küçük Resim
    Öğe
    Candida albicans’a bağlı Fournier gangreni
    (2008) Temiz, Muhyittin; Çetin, Meryem; Aslan, Ahmet
    Fournier gangreni perineal, genital veya perianal bölgenin fulminan nekrotizan fasiiti ile karakterize olup genellikle aerop ve anaerop bakterilere bağlı olarak gelişir. Idiyopatik olduğu düşünülse de, diyabetli, uzun süre alkol kullanan ve immün yetmezliği olan hastalar daha fazla etkilenmektedir. Etken genellikle üriner sistem, alt gastrointestinal sistem veya ciltte yerleşmektedir. Gangrenin ortaya çıkışı ve ilerlemesi çok hızlı olup, çoklu organ yetmezliği ve ölümle sonlanabilir, Bu raporda Candida albicans'in sebep olduğu bir Fournier gangreni olgusu sunulmaktadır. Elli dokuz yaşında bir kadın hasta, üç hafta önce oluşan travma sonrası sağ kalçada gelişen şişlik ile hastanemize başvurmuştur. Hastanın öyküsünden, diabetes mellitus, esansiyel trombositopeni, kronik hastalık anemisi ve hipertansiyon nedeniyle daha önceden dört kez hastaneye yatırıldığı öğrenilmiştir. Sağ trokanterik kırık saptanan hasta, kırığa ikincil anaerobik yumuşak doku enfeksiyonu ön tanısı ile operasyona alınmış ve yaygın nekroz nedeniyle geniş debridman uygulanmıştır. Ampirik olarak sefalosporin ve metronidazol tedavisi verilen hastanın yara yeri ve kan kültürü örneklerinde primer etken olarak C.albicans üremesi saptanmış, bunun üzerine tedaviye flukonazol eklenmiştir. Ancak hasta, fungal sepsisten kaynaklanan çoklu organ yetmezliğine bağlı olarak postopera-tif 25. gün eksitus olmuştur. Bu olgu, diabetik hastalarda gangrenli dokularda mayaların da patojen etkenler arasında düşünülmesi gerektiğinin vurgulanması amacıyla sunulmuştur.
  • Küçük Resim
    Öğe
    Çocuklarda anorektal travma sonucu gelişen rektum perforasyonu : İki olgu sunumu
    (2011) Temiz, Abdülkerim; Akçora, Bülent; Temiz, Muhyittin; Aslan, Ahmet
    Anorektal yaralanma çocuklarda nadir görülen bir klinik tablodur. Rektum ve diğer intrapelvik organların yaralanmaya eşlik etmesi açısından da önemlidir. Olgu 1: Karın ağrısı ve kusma şikayetleri ile başvuran 9 yaşındaki erkek hastada, karında yaygın hassasiyet ve defans tespit edildi. Ayakta karın grafisinde diyafragma altında serbest hava izlendi. Ameliyatta rektum ve mesane perforasyonu tespit edildi. Yara onarımı ve sigmoid kolostomi yapıldı. Olgu 2: Altı yaşında kız hasta, ağaçtan düşme sonrası gelişen perineal yaralanma nedeniyle kliniğimize başvurdu. Fizik muayenesinde perinede anal kanaldan yaklaşık 4 cm uzaklıkta, 2 cm çaplı, derin planda ilerleyen perineal yara tespit edildi. Ayakta karın grafisinde diyafragma altında serbest hava gözlendi. Ameliyatta rektum perforasyonu tespit edilen hastada, perforasyon onarımı ve sigmoid kolostomi yapıldı. Anorektal yaralanmalarda morbidite ve mortalitenin azaltılması için erken ve doğru tanı, yaralanmanın şekli ve tipinin doğru belirlenmesi, ek organ yaralanmaların tespiti ve uygun yöntemle tedavisi gereklidir. Tedavide gereken olgularda kolostomiden kaçınılmaması gerektiğini düşünüyoruz.
  • Küçük Resim
    Öğe
    Comparison of Recovery Characteristics, Postoperative Nausea and Vomiting, and Gastrointestinal Motility With Total Intravenous Anesthesia With Propofol Versus Inhalation Anesthesia With Desflurane for Laparoscopic Cholecystectomy: A Randomized Controlled Study
    (Elsevier Science Inc, 2009) Akkurt, B. Cagla Ozbakis; Temiz, Muhyittin; Inanoglu, Kerem; Aslan, Ahmet; Turhanoglu, Selim; Asfuroglu, Zeynel; Canbolant, Elif
    BACKGROUND: Clinical effects, recovery characteristics, and costs of total intravenous anesthesia with different inhalational anesthetics have been investigated and compared; however, there are no reported clinical studies focusing on the effects of anesthesia with propofol and desflurane in patients undergoing laparoscopic cholecystectomy. OBJECTIVE: The aim of this study was to determine the effects of total intravenous anesthesia with propofol and alfentanil compared with those of desflurane and alfentanil on recovery characteristics, postoperative nausea and vomiting (PONV), duration of hospitalization, and gastrointestinal motility. METHODS: Patients classified as American Society of Anesthesiologists physical status I or II undergoing elective laparoscopic cholecystectomy due to benign gallbladder disease were enrolled in the study. Patients were randomly assigned at a 1:1 ratio to receive total intravenous anesthesia with propofol (2-2.5 mg/kg) and alfentanil (20 mu g/kg) or desflurane (4%-6%) and alfentanil (20 mu g/kg). Perioperative management during premedication, intraoperative analgesia, relaxation, ventilation, and postoperative analgesia were carried out identically in the 2 groups. Extubation time, recovery time, PONV, postoperative antiemetic requirement, time to gastrointestinal motility and flatus, duration of hospitalization, and adverse effects were recorded. Postoperative pain was assessed using a visual analogue scale. RESULTS: Sixty-eight patients were assessed for inclusion in the study; 5 were excluded because they chose open surgery and 3 did not complete the study because they left the hospital. Sixty patients (33 women, 27 men) completed the study. Recovery time was significantly shorter the propofol group (n = 30) compared with the desflurane group (n = 30) (8.0 [0.77] vs 9.2 [0.66] min, respectively; P < 0.005). Fifteen patients (50.0%) in the propofol group and 20 patients (66.7%) in the desflurane group experienced nausea during the first 24 hours after surgery. The difference was not considered significant. In the propofol group, significantly fewer patients had vomiting episodes compared with those in the desflurane group (2 [6.7%] vs 16 [53.3%]; P < 0.005). Significantly fewer patients in the propofol group required analgesic medication in the first 24 hours after surgery compared with those in the desflurane group (10 [33.3%] vs 15 [50.0%]; P < 0.005). Patients in the propofol group experienced bowel movements In a significantly shorter period of time compared with patients in the desflurane group (8.30 [1.67] vs 9.76 [1.88] hours; P = 0.02). The mean time to flatus occurred significantly sooner after surgery in the propofol group than in the desflurane group (8.70 [1.79] vs 9.46 [2.09] hours; P = 0.01). The duration of hospitalization after Surgery was significantly shorter in the propofol group than in the desflurane group (40.60 [3.49] vs 43.60 [3.56] hours; P = 0.03). CONCLUSION: Total intravenous anesthesia with propofol and alfentanil was associated with a significantly reduced rate of PONV and analgesic consumption, shortened recovery time and duration of hospitalization, accelerated onset of bowel movements, and increased patient satisfaction compared with desflurane and alfentanil in these patients undergoing laparoscopic surgery who completed the study. (Curr Ther Res Clin Exp. 2009;70:94-103) (C) 2009 Excerpta Medica Inc.
  • Küçük Resim
    Öğe
    COVID-19 pandemisi döneminde onkolojik ve acil cerrahi vakalarının yönetimi
    (2022) Dal, Mehmet Burak; Uğur, Mustafa; Duymuş, Mehmet Esat; Temiz, Muhyittin
    Amaç: Acil cerrahi vakalara Genel Cerrahide önemli bir yer tutmaktadır. COVID-19 salgını döneminde, hastaların salgından etkilenme korkusu ve davranış şekillerinin karmaşıklığı bu hastalıkların teşhis ve tedavisini zorlaştırmaktadır. Yöntem: Üçüncü basamak olan merkezimizde, COVID pandemisi sırasında akut apandisit, kolesistit ve kolorektal kanser tanısı ile cerrahi geçiren hastaların bilgisayarlı veri tabanı retrospektif olarak pandemi öncesi ve pandemi dönemi şeklinde gözden geçirildi. Bulgular: Çalışma süresi boyunca 1100 hasta apandisit, 500 hasta kolesistit, 120 hasta onkolojik hastalıklar nedeni ile ameliyat edildi. Ortalama yaş her iki dönem için benzerdi, pandemi öncesi dönemde 34.06 ± 16.7 pandemi döneminde 36,72 ± 15,31 yaş ortalaması mevcuttu. Semptom başlaması ile hastaların hastaneye başvuru süreleri her iki döneme benzerdir (34,55 ± 31,51 ile 34,35 ± 37,94 sa, P = 0,968). Laboratuvar testler arasında anlamlı bir farklılık göstermemiştir. WBC değerleri pandemi öncesi dönemde 12.73 ± 4.3 × 103 idi pandemi sonrası dönemde 13.62 ± 4.62×103 (P = 0.1308) idi. Pandemi öncesi ve pandemi döneminde tüm hastalar en az 1 görüntüleme yöntemi kullanılmıştır. Sonuç: COVID-19 pandemisinin ilk aşamasında, komplike acil cerrahi gereksinimi oranında önemli bir artış vardı. Hastalar bundan kaçınmaları için semptomların başlaması ile acil polikliniklere başvurmaları şiddetle teşvik edilmelidir.
  • Küçük Resim
    Öğe
    CREB1 and PPAR-?/? Pathways in Hepatic Ischemia/Reperfusion: Route for Curcumin to Hepatoprotection
    (Briefland, 2022) Demir, Enver Ahmet; Tutuk, Okan; Dogan-Gocmen, Hatice; Ozyilmaz, Duygu Seren; Karagul, Meryem Ilkay; Kara, Mikail; Temiz, Muhyittin
    Background: Hepatic ischemia/reperfusion injury is a major problem that can exacerbate complications, particularly in liver trans-plantations. Objectives: This study aimed to investigate the cellular mechanisms of ischemia/reperfusion injury and hepatoprotection by cur -cumin. Methods: Wistar albino rats were divided into four groups as Control, Sham, I/R, and Cur+I/R. Hepatic ischemia/reperfusion was induced in I/R and Cur+I/R animals, the latter of which was also given 50 mg/kg/day of curcumin for 14 days. Liver aminotransferases and the transcription regulators of inflammation (RelA, I & kappa;B, PPAR-& alpha;, PPAR-& gamma;, CREB1) were examined along with the histological examination. Results: Hepatic ischemia/reperfusion was found to disrupt hepatic microstructure and downregulate PPAR-& alpha;, PPAR-& gamma;, and CREB1 transcripts. Curcumin supplementation in hepatic ischemia/reperfusion recovered the structural organization and promoted the hepatocyte regeneration while increasing expressions of PPARs and CREB1. RelA and I & kappa;B were found unaltered, possibly due to the crosstalk between targeted transcripts by ischemia/reperfusion and curcumin. Conclusions: In sum, PPAR-& alpha;/& gamma; and CREB1 were involved in hepatic ischemia/reperfusion and, moreover, were detected to be stim-ulated by curcumin. PPAR and CREB pathways were found to provide a route to hepatoprotection for curcumin supplementation as evidenced by the microstructural improvement.
  • Küçük Resim
    Öğe
    Determination of the Knowledge Levels on Hepatitis B Virus of Residents at Mustafa Kemal University Hospital
    (Galenos Yayincilik, 2007) Cetin, Meryem; Temiz, Muhyittin; Aslan, Ahmet; Turhan, Ebru
    The purpose of this study was to determine the general knowledge levels of the residents in Mustafa Kemal University Hospital on hepatitis B virus (HBV) infection. A total of 60 residents were asked to fill in a questionnaire. It was observed that 31 out of 60 (51.7%) answered the question correctly on the general knowledge, 9 out of 60 (15%) on transmission routes, 5 out of 60 (8.3%) on prevention measures, and 59 out of 60 (98.3%) on risk factors of HBV infection. A significant difference was observed between the knowledge scores of the participants with sex and employment duration whereas no difference was determined between the knowledge scores, with age and departments of the participants. The result of this study demonstrates that the residents, who were under the risk of HBV infection, did not have enough knowledge on the overall characteristics, transmission routes, and prevention measures of HBV infection. It was concluded that, periodic workshops are necessary after graduation from the medical school to keep doctors informed and updated on this particular infection.
  • [ N/A ]
    Öğe
    Does cyclin E and p57kip2 expression have prognostic and survival value in colorectal adenocarcinoma?
    (E-Century Publishing Corp, 2018) Ozgur, Tumay; Sumbul, Ahmet Taner; Yaldiz, Mehmet; Temiz, Muhyittin; Akdag, Abdurrahman
    Introduction: Colorectal cancer is still one of the main causes of cancer death in the world. There is a continous need for novel biomarkers for diagnose, treatment modalities and follow-up. Cyclin E and p57(KIP2) as the positive and negative regulators of cell cycle seem to be an important target for investigations. Materials and methods: In a retrospective setting, primary colorectal adenocarcinoma cases examined in Mustafa Kemal University, School of Medicine, Pathology Department between 2008-2015 were reviewed. Immunohistochemical expressions of cyclin E and p57(KIP2) in 80 pairs of colorectal carcinoma and adjacent normal mucosal tissues were evaluated and the findings were compared with clinicopathological parameters and survival time. Results: There were no statistically significant difference between two groups both in cyclin E and p57(KIP2) stained tissues (P>0.05). There were 40 (50%) patients in high-expression group and 40 (50%) patients in low-expression group for cyclin E. P57(KIP2) was negative in 55 (68.75%) patients and positive in 25 (31.75%) patients. There were no statistically significant relation between p57(KIP2) and cyclin E expressions with clinicopathologic parameters defined as age, gender, lymphovascular invasion, perineural invasion, depth of invasion, nodal involvement, emergency in operation, perforation before operation and overall survival except that there was significant relation between p57(KIP2) expression and histological grade (P=0.012). Conclusions: Immunohistochemical studies of cyclin E and p57(KIP2) should be performed with larger series of patients supported by more detailed technical research methods to be candidates as predictive markers for treatment modalities and prognostic factors.
  • Küçük Resim
    Öğe
    Effect of mesalamine on healing in experimental colon anastomosis: A randomised experimental study
    (2008) Aslan, Ahmet; Temiz, Muhyittin; Hakverdi, Sibel; Polat, Gurbuz; Tumer, Cemil; Temiz, Abdulkerim; Canbolant, Elif
    Objective: We aimed to investigate the effect of mesalamine on healing of experimental colon anastomosis model. Material/Methods: Forty adult male Wistar albino rats were performed segmentary colonic resection and end-to-end anastomosis. Animals were randomly divided into four groups: group I, anastomosis group, received no treatment (GI, n = 8); group II, anastomosis + oral mesalamine group (100 mg/kg/day); group III, anastomosis + rectal mesalamine (2 mL) group, (GIII, n = 8); group IV, anastomosis + oral mesalamine + rectal mesalamine (GIV, n = 8) group. A sham group (n = 8) was constituted and was performed laparotomy. Bursting pressure, hydroxyproline levels and histopathological characteristics of the anastomosis were analyzed. Results: Although it was not statistically significant, there was an increase in the burst pressure of the mesalamine group. When hydroxyproline measurements were compared there were statistically significant difference between the non-treated colon and all groups. There were significant differences between GI and GIII-GIV, GII and GIV. The differences between group I and II and group II and III were not statistically significant. When we compared the median amount of the histopathological changes, we found significant difference between the anastomosis and the mesalamine groups (P < 0.05). But when mesalamine groups were compared with each other we did not observe a significant difference. Conclusion: Mesalamine had positive effects which were not statistically significant on bursting pressure and statistically different significant effects on hydroxyproline (HP) levels based on the way of administration and statistically significant positive effects on histopathologic anastomotic healing in experimental anastomosis model. © 2007 Surgical Associates Ltd.
  • Küçük Resim
    Öğe
    Effect of propolis on healing in experimental colon anastomosis in rats
    (Springer, 2008) Temiz, Muhyittin; Aslan, Ahmet; Canbolant, Elif; Hakverdi, Sibel; Polat, Gurbuz; Uzun, Semire; Temiz, Abdulkerim
    Introduction: Propolis is the generic name for the resinous substance collected by honeybees, which is known to have antioxidant, anti-inflammatory, apoptosis-inducible effects. Anastomotic dehiscence after colorectal surgery is an important cause of morbidity and mortality. We aimed to assess the effect of propolis on healing in an experimental colon anastomosis in rats. Methods: Forty adult male Wistar albino rats were randomly assigned into 5 treatment groups with 8 rats in each: Group I, anastomosis+no treatment; Group II, anastomosis+oral propolis ( 600 mg/ kg/ d); Group III, anastomosis+oral ethyl alcohol ( 1 cc/ d); Group IV, anastomosis+rectal propolis ( 600 mg/ kg/ d); Group V, anastomosis+rectal ethyl alcohol ( 1 cc/ d). The bursting pressures, hydroxiproline levels and histopathological changes in each group were measured. Results: When bursting pressures were compared between groups, we observed that they were increased in the groups treated with propolis in contrast to all other groups. Hydroxiproline levels in the propolis groups were also significantly increased in contrast to the other groups. There was also a statistically significant difference in histopathological changes between the treatment types. When propolis administration methods were compared, we did not observe a statistically significant difference. Conclusion: Propolis has a significantly favourable effect on healing in experimental colon anastomosis, independent from the method of administration.
  • Küçük Resim
    Öğe
    The effect of propolisis and mesalazine on bacterial translocation in an experimental colitis model
    (Saudi Med J, 2007) Aslan, Ahmet; Cetin, Meryem; Temiz, Muhyittin; Sahinler, Nuray; Besirov, Elmir; Aban, Nedim
    [Abstract Not Available]
  • Küçük Resim
    Öğe
    Effectiveness of mesalamine and propolis in experimental colitis
    (Springer, 2007) Aslan, Ahmet; Temiz, Muhyittin; Atik, Esin; Polat, Gurbuz; Sahinler, Nuray; Besirov, Eimir; Aban, Nedim
    This study was conducted to investigate the effects of propolis and mesalamine on experimental colitis in rats. Distal colitis was induced in rats by intracolonic instillation of 2 mL of 4% acetic acid. The animals were randomly assigned to 5 groups: group 1, control, (n=8); group 2, colitis, received no treatment (n=8); group 3, colitis+mesalamine, 2 mL once a day via an enema (n=8); group 4, colitis+propolis, 600 mg/kg once a day via intragastric lavage (n=8); and group 5, colitis+ mesalamine+propolis for 1 wk (n=8). Levels of nitric oxide were statistically significantly different in comparisons between groups 1 and 2, groups 2 and 3, and groups 4 and 5. Malondialdehyde levels were significantly different when group 2 was compared with groups 3, 4, and 5. A significant difference was observed when group 3 was compared with group 4 for myeloperoxidase. Most propolis-treated rats had normal histology; mesalamine-treated and propolis+mesalamine-treated rats had inflammatory cell infiltration at rates of 50% and 33%, respectively. The investigators concluded that propolis and mesalamine are efficient independently and in combination, but that their combined effect was not observed to be additive in experimental colitis.
  • Küçük Resim
    Öğe
    Effects of temporary abdominal closure methods on mortality and morbidity in patients with open abdomen
    (Ulusal Travma ve Acil Cerrahi Derneği, 2018) Kılıç, Erol; Uğur, Mustafa; Yetim, İbrahim; Temiz, Muhyittin
    BACKGROUND: Open abdomen (OA) in which the abdomen is closed with temporary abdominal closure methods is the most effective in patients who develop severe abdominal sepsis or abdominal compartment syndrome. Major techniques used are Vacuum-Assisted Closure Method (VACM) and non-vacuum assisted closure method (NVACM). In the present study, the effects of different abdominal closure methods on morbidity and mortality were evaluated. METHODS: In the study, the temporary abdominal closure methods of the patients with OA during 2013–2016 were studied retrospectively. OA etiopathologies, mortality prediction scores, final abdominal closure periods and methods, hospitalization periods, complications (enteroatmospheric fistula, mesh infection, and incisional hernia), and mortality rates of patients who underwent VACM and NVACM were determined and compared. RESULTS: The present study included 123 patients who underwent VACM (n=65) and NVACM (n=58). There was no difference between the groups in terms of age, gender, and etiopathogenesis (p>0.05). The mean APACHE 4 and Multiple Organ Dysfunction Score (MODS) scores in the VACM/NVACM groups in treatment period were 47/63 and 11/14, respectively (p<0.05). The mean intensive care and hospitalization periods in the VACM/NVACM groups were 11/16 (days) and 22/28 (days), respectively (p<0.05). The collection and abscess development rates in the VACM and NVACM groups were 46.2% and 77.6%, respectively (p<0.05). The rate of enteroatmospheric fistula (EAF) development in the VACM and NVACM groups were 15.4% and 56.9%, respectively (p<0.05). The mean abdominal closure times in the VACM and NVACM groups were 13 and 17 days, respectively (p<0.05). Mortality rate in the VACM and NVACM groups were 18% (n=18) and 55% (n=32), respectively (p<0.05). CONCLUSION: In patients with OA, the temporary abdominal closure technique VACM has lower complication and mortality rates and shorter hospitalization period than other methods. Therefore, it is an effective and safe method for the treatment of OA.
  • Küçük Resim
    Öğe
    Evaluation of preoperative anxiety in cancer patients: Experience of a single center
    (2022) Duymuş, Mehmet Esat; Urfalı, Senem; Uğur, Mustafa; Dal, Mehmet Burak; Dönmez, Yasemin; Bağ, Yusuf Murat; Temiz, Muhyittin
    Anxiety disorder is observed in half of the patients in the preoperative period. Psychological disorders are also frequently observed in cancer patients and need to be supported. The aim of the present study is to determine the level of preoperative anxiety in patients with malignant and benign diagnoses who were planned for elective surgery and to reveal its relationship with socio-demographic data. A tertiary hospital-based cross-sectional study was conducted in the general surgery clinic between June 1, 2021- March 31, 2022, on 158 patients who underwent elective surgery. Participants were evaluated in two groups depending on their diagnosis; the cancer group and the benign group. The socio-demographic data were recorded and the level of anxiety was determined by the Beck Anxiety Inventory (BAI). The median age of par- ticipants was 55 (19-78) years. There were 72 (45.6%) patients in the cancer group and 86 (54.4%) patients in the benign group. There was no significant difference in age, gender, marital status, job, level of income, and family cancer history between the two groups. There were significant differences between the groups in level of education, and previous surgical history (p=0.035, and p=0.037, respectively). BAI scores of the cancer group and control group were 10.5 (0-35) and 5 (0-49), respectively (p<0.001). The level of anxiety in the cancer group was also significantly higher than in the benign group (p<0.001). Cancer patients have more anxiety during the preoperative period than patients who were with benign diseases. We believe that previous surgical history and education level are other factors that affect anxiety.
  • Küçük Resim
    Öğe
    Fibroadenom ile karışabilen büyük meme hamartomu
    (2008) Temiz, Muhyittin; Aslan, Ahmet; Bozkurtoğlu, Hakan; Atik, Esin; Beyaz, Fikret; Canbolant, Elif; Beşirov, Elmir; Aban, Mahmut Nedim
    Meme hamartomları memenin nadir görülen iyi huylu kitleleridir. Genellikle iyi sınırlı, ağrısızdır. Cilt veya pektoral kaslarla bağlantısı yoktur ve aynı taraf memede asimetrik büyümeye sebep olurlar. Hareketli olup histoljik olarak değişik oranlarda yağ, gland, f bröz veya kas dokusu içerebilirler. Spesifik olmayan sitolojik bulgularından dolayı bu lezyonların preoperatif tanısı zordur. Radyolojik olarak mamografide ‘meme içinde meme' karakteristik bulgusu olup, tanıya gitmede ultrason ve magnetik rezonans görüntülemeden de faydalanılır. Tanıda iğne biopsileri çok faydalı olmaz. Tanımlamadaki zorluk, lezyonun klinik radyolojik ve patolojik değerlendirmesinin beraber yapılması ile aşılabilir. Tedavisi cerrahi eksizyondur. Bu makalede, nadir görülen bu lezyonu, yayınlanmış olguların pek çoğundan daha büyük bir olgu ile literatür eşliğinde tartışmak istedik.