Yazar "Tokur, M." seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim
    Öğe
    Comparing the effects of fluticasone, anti-IgE and anti-TNF treatments in a chronic asthma model
    (Elsevier Doyma Sl, 2018) Ozkars, M. Y.; Keskin, O.; Tokur, M.; Ulasli, M.; Gogebakan, B.; Ciralik, H.; Kucukosmanoglu, E.
    Background: Corticosteroids are used in the treatment of asthma. The aim of this study was to determine the efficacy of anti-IgE and anti-TNF alpha as asthma treatments. Methods: A mouse model of chronic asthma was developed. The fluticasone group was exposed to fluticasone and the anti-IgE and anti-TNF groups were administered anti-IgE or anti-TNF. IL-4, and IgE levels were measured, and histological analysis, pathological analysis and miRNA-126, miRNA-133a analyses were applied. Results: The cell concentration in the BAL fluid decreased in all the treatment groups. The rate of perivascular and peribronchial cell infiltration decreased in the lung in the high-dose anti-IgE and anti-TNF groups. Smooth muscle thickness decreased in the lung tissue in the low dose anti-IgE and anti-TNF groups. Bronchial wall thickness decreased in the lung tissue in the fluticasone + antidgE group. The IL-4 level in BAL fluid decreased in the high-dose anti-IgE, fluticasone + anti-IgE and anti-TNF groups. IgE levels increased in the BAL fluid in the high dose anti-IgE and anti-TNF groups. The lymphocyte level increased in the BAL fluid in the high-dose anti-IgE group. The macrophage level decreased in the BAL fluid in the anti-TNF group. The relative expression of miRNA-126 increased in all groups. The relative expression of miRNA-133a decreased in the placebo and fluticasone groups. The relative expression of miRNA133a increased in the low-dose anti-IgE, high-dose anti-IgE, fluticasone + anti-IgE and anti-TNF groups. Conclusions: The results showed that anti-IgE is successful as a treatment. Fluticasone + antiIgE and anti-TNF were seen to be superior to other therapeutic modalities when used for prophylaxis. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
  • [ N/A ]
    Öğe
    Effects on cells in the BAL fluid of asthma medications
    (Wiley-Blackwell, 2015) Ozkars, M. Y.; Keskin, O.; Tokur, M.; Gogebakan, B.; Ciralik, H.; Kucukosmanoglu, E.; Demirel, C.
    [Abstract Not Available]
  • [ N/A ]
    Öğe
    Effects on histological changes on the BAL fluid of asthma medications
    (Wiley-Blackwell, 2015) Ozkars, M. Y.; Keskin, O.; Tokur, M.; Gogebakan, B.; Ciralik, H.; Kucukosmanoglu, E.; Demirel, C.
    [Abstract Not Available]
  • [ N/A ]
    Öğe
    Effects on IL-4 and IgE on the BAL fluid of asthma medications
    (Wiley-Blackwell, 2015) Ozkars, M. Y.; Keskin, O.; Tokur, M.; Gogebakan, B.; Ciralik, H.; Kucukosmanoglu, E.; Demirel, C.
    [Abstract Not Available]
  • [ N/A ]
    Öğe
    Effects on miRNA on the lung tissue of asthma medications
    (Wiley-Blackwell, 2015) Ozkars, M. Y.; Keskin, O.; Tokur, M.; Gogebakan, B.; Ciralik, H.; Kucukosmanoglu, E.; Demirel, C.
    [Abstract Not Available]