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    Herbal supplement usage in cardiac patients
    (Turkish Soc Cardiology, 2017) Pinar, Neslihan; Topaloglu, Meyli; Ozer, Cahit; Alp, Harun
    Objective: Complementary and alternative medicine (CAM) has become more and more widespread around the world. CAM is a broad term that refers to all medical healthcare services, methods, and practices that are not part of standard medical care, as well as the accompanying theories and beliefs. The aim of the present study was to investigate the use of herbal medicinal products in cardiac patients, as well as the methods of administration of the products. Methods: This descriptive cross-sectional study included 199 patients aged over 18 years who were hospitalized in the Defne Hospital department of cardiology and volunteered to participate in a 20-item survey between April 2016 and June 2016. Results: The study results indicated that 28.6% (n=57) of the patients were using herbal medicinal products and 71.6% (n=142) said they did not. Only 14.03% (n=8) of those who used herbal medicinal products said they used them in consultation with their physician; 85.9% (n=49) had used herbal medicine without consulting their doctor. Of the participants with hypertension, 35.7% of them reported using herbal medicinal products. Of these, 22.5% of them were consuming lemon, 17.5% pomegranate syrup, and 17.5% green tea. Of the participants with cardio-vascular diseases, 23.5% of them stated that they were taking herbal medicinal products. Of these, 25% were consuming green tea, 25% ginger, and 18.8% sage. Conclusion: Herbal medicinal supplements were used by a large portion of the cardiac patients in this study. Furthermore, most of the patients stated that they were using these products without informing their physician, a practice that can have unwanted consequences.
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    Protective effect of dexpanthenol on cisplatin induced nephrotoxicity in rats
    (Taylor & Francis Ltd, 2022) Pinar, Neslihan; Topaloglu, Meyli; Secinti, Ilke Evrim; Buyuk, Esra; Kaplan, Mahir
    Cisplatin (CIS) is an antineoplastic agent used for treating solid organ tumors. Toxic side effects of CIS treatment include nephrotoxicity, neurotoxicity, ototoxicity, myelosuppression and hepatotoxicity. Dexpanthenol (DEX) exhibits antioxidant and anti-inflammatory effects and protective effects against free oxygen radicals. We investigated the protective effects of DEX on CIS induced nephrotoxicity. Animals were divided into four groups of 10. The control group was given saline. The DEX group was treated with DEX for 10 days. The CIS group was treated with a single dose of CIS. The DEX + CIS group was given a single dose of CIS followed by DEX for 10 days. We found increased levels of malondialdehyde (MDA), blood urea nitrogen (BUN) and creatinine, while superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and myeloperoxidase (MPO) levels were decreased in the CIS group. MDA, BUN and creatinine levels were decreased, while SOD, CAT, GPx and MPO levels were increased in the DEX + CIS group. Renal tubule damage, inflammation and histopathology scores were significantly higher in the CIS group than the control. The DEX + CIS group exhibited less renal tubule damage and inflammation, and lower histopathological assessment scores than the CIS group. Significant cortical tubule damage and interstitial inflammation were observed in the CIS group. Tubule damage was slightly less, and mild tubule dilation and less cast formation were observed in the DEX + CIS group; also, inflammation was less severe than for the CIS group. DEX may have therapeutic potential for treating CIS induced nephrotoxicity due to its antioxidant and anti-inflammatory properties.
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    The Use of Herbal Supplements of Diyabetic Patients Attending the University Hospital in Hatay, Endocrine Polyclinic
    (Duzce Univ, 2017) Pinar, Neslihan; Topaloglu, Meyli; Ozsan, Muge; Ozer, Cahit; Alp, Harun
    Objective:Today, people are increasingly interested in complementary and alternative medicine (TAT) practices. These are the most preferred herbal products by patients. Herbal products are also widely used in diyabetes patients. The use of herbal products in diyabetic patients can lead to morbidity and mortality. The present study aimed to investigate the use of herbal supplements in diyabetic patients as well as the methods of administration and the side effects of the products. Methods:The cross-descriptive study was carried out from May to June 2016 and enrolled 150 patients aged over 18 years who applied to Mustafa Kemal University Medical Hospital Endocrinology Outpatients. Results:Of the 150 participants, 60.7% (n:91) were male while 39.3% (n:59) were female and 22% (n:33) of them reported herbal supplement use. The most preferred supplements were, cinnamon 5.3% (n:8), lemon 4.7% (n:7), pomegranate syrup 3.3% (n:5), green tea 2.7% (n:4), 2.0% almond (n:3), 1.3% (n:2) yarrow, sage and olive leaves. None of them declared a consultation about these CAM with their doctor. Also none of them declared a side effect. Conclusion:Herbal supplements are used by a great majority of diyabetic patients, but none of them were using herbal supplements by physician advice. The use of herbal supplements without physician control may lead to undesirable outcomes for diyabetic patients.