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Öğe Descriptive epidemiology of non-hodgkin's lymphomas in Hatay(2013) Özgür, Tümay; Yaldiz, Mehmet; Kaya, Hasan; Yengil, Erhan; Toprak, SerhatThe incidence of Non-Hodgkin's Lymphomas (NHL) varies among different parts of the world. NHL are the 12th most common cancer in Europe and increasing dramatically during the last years. In this study, it was aimed to analyse the descriptive epidemiology of NHL in Hatay region with retrospective archieve datas. One hundred and thirty-three NHL cases between 2005 and 2013 have been reviewed retrospectively in the Pathology Department of the Mustafa Kemal University. All of the cases were classified according to World Health Organization modified in 2008. Eighty-two (61.7%) cases were male and 51 (38.3%) cases were female. Ninety-two of the cases (69.2%) were nodal lymphoma, and the remaining 41 (30.8%) were extranodal lymphoma. The most common extranodal involvement regions were tonsils and nasopharynx with frequencies of 21.9% (9) and 19.5% (8), respectively. The age distribution pattern revealed that NHL were mostly diagnosed in the ages of 41-65 years in nodal (41.3%) and extranodal sited NHL groups (53.6%). The most frequent NHL was diffuse large cell B cell lymphoma (50.4%) and chronic lymphocytic leukemia/small lymphocytic lymphoma (17.3%). Our results were similar with the literature. Further epidemiologic studies with larger series defining the profile of NHL subtypes may be more worthy.Öğe Do histopathologic findings improve by increasing the sample size in cholecystectomies?(Biomed Central Ltd, 2013) Ozgur, Tumay; Toprak, Serhat; Koyuncuer, Ali; Guldur, Muhammed; Bayraktar, Gurman; Yaldiz, MehmetBackground: Gallbladder diseases present with cholelithiasis in a wide spectrum of adenomas and cancers. Two or three specimens are sampled in cholecystectomies in routine pathology practice. The aim of this study was to investigate the increase in frequency of histologic alterations in cholecystectomies, particularly precancerous lesions, by increasing the sample size to understand the carcinoma pathway. Methods: Cholecystectomies of 432 patients with pathology records and materials from two medical centers were collected, and two groups were created. Initial data with two or three samples were allocated to Group 1 and the new six samples with the initial ones were allocated to Group 2. Hematoxylin and eosin (H&E) sections were examined for histopathologic alterations, and periodic acid-Schiff (PAS) Alcian blue (pH 2.5) and high iron diamine (pH 2.5) stains were used to signify the mucin profile in case of metaplasias. For the comparison of findings, non-parametric tests, McNemar's tests, chi-squared tests and Fisher's exact test were performed. Results: Of the 432 patients, 308 (71.3%) patients were female and 124 (28.7%) patients were male. The mean age of patients was 47.9 +/- 14.6 years. Cholesterolosis was observed in 95 (22%) patients in Group 1 and 108 (25%) patients in Group 2. Gallstones were detected in 255 (59%) of the cholecystectomies. There was a significant difference between Group 1 and Group 2 by increasing the sample size when we compared cholesterolosis, metaplasia and polyps (P < 0.05). Cholecystitis and dysplasia rates were the same in both of the groups. There was no cancer determined. Conclusion: Increasing the sample size in cholecystectomies increased the diagnosis of some histologic alterations, but further studies with a larger number of samples over a longer period time might increase the ability to determine precancerous lesions and concomitants.Öğe Endometrium atipili kompleks hiperplazi ve adenokarsinomlarında PTEN ve PIK3CA ekspresyonunun prognostik faktörlerle ilişkisi(Hatay Mustafa Kemal Üniversitesi, 2014) Toprak, Serhat; Hakverdi, SibelAmaç: Endometrium atipili kompleks hiperplazi (KAH) ve endometrioid endometrial adenokarsinomlarında (EEK), PTEN (Phosphatase and tensin homolog) ve PIK3CA (Fosfatidil inositol 3 kinaz katalitik alfa) ekspresyonun prognostik faktörlerle ilişkisini araştırmak. Yöntem: Atipili kompleks hiperplazi ve çeşitli evrelerde EEK tanısı almış hastalara ait parafin blokların immünohistokimyasal olarak PTEN ve PIK3C antikorları ile boyanma sonuçlarının prognostik faktörlerle ilişkilerinin istatistiksel olarak saptanması. Bulgular: PTEN ekspresyon kaybını KAH'de %28, EEK'de %86 olarak, EEK da derece I, II, III te sırasıyla %92,3, %81,5,%90, FİGO evre IA, IB, II, IIIA, IIIC1, ve IVB de sırasıyla %84,6, %86,4, %100, %100, %80, %100, myometrial invazyon derinliği <1/2 olanlarda %86,2, >1/2'den fazla olanlarda %85,7, lenfovasküler invazyonu mevcut olanlarda %100, olmayanlarda %82,1 bulduk. PIK3C ekspresyonu KAH'da %4, EEK'da %68 olarak, EEK da derece I, II, III'te sırasıyla %84, %66,7, %50, FİGO evre IA, IB, II, IIIA, IIIC1, ve IVB de sırasıyla, %65, %76,9, %0, %66,7, %80, %50, myometrial invazyon derinliği >1/2 olanlarda %71,4, <1/2 olanlarda %65,5, lenfovasküler invazyonu mevcut olanlarda %72,7, olmayanlarda % 66,7 oranında bulduk. Sonuçlar: PTEN ekspresyon kaybının EEK'lu olgularda, KAH'li olgulara daha yüksek olduğu, PTEN ekspresyonun histolojik derece ile ilişkili olmadığı, evre artıkça PTEN ekspresyonun azaldığı, PIK3C ekspresyonun tümör derecesi, evresi, lenf nodu tutulumu, lenfovasküler invazyon, myometrial invazyon derinliği gibi kötü prognostik faktörlerin varlığında arttığı bulundu, fakat bu korelasyonun istatistiksel olarak anlamlı olmadığı bulundu.Öğe Evaluation of fetal autopsy findings in the Hatay region : 274 cases(2012) Hakverdi, Sibel; Güzelmansur, İsmail; Güngören, Arif; Toprak, Serhat; Yaldız, Mehmet; Hakerdi, Ali UlviObjective: The aim of this study was to present the incidence of fetal anomalies in our region of Hatay, Turkey in order to determine the efficiency of prenatal diagnosis through fetal autopsy, and to compare our statistical data with other national and international studies. Material and Method: This study was conducted on 274 fetuses from terminated pregnancies due to abnormal prenatal findings and intrauterine deaths from 2005 to September 2010. Fetuses were evaluated through postmortem examination, external measurements, X-rays, Magnetic Resonance Images, Multislice Computerized Tomography and photographs. The autopsy was completed by the histological examination of each organ. Results: Autopsy was conducted on 274 fetuses. A fetal anomaly was detected in 160 (58.39%) cases. The central nervous system contained the most frequent structural defects (79 cases, 49.38%), followed by malformations in the musculoskeletal system in 36 cases (22.5%). The most frequent multiple system anomalies were central nervous system defect and bilateral adrenal agenesis, musculoskeletal system malformations and urinary system defects. Fetal autopsy provided additional findings in 43 cases (26.88%). Conclusion: Fetal autopsy is a very important procedure and an integral part of the general prenatal management. New findings through this method may suggest invaluable data for parents about potential risks in future pregnancies.Öğe Evaluation of Fetal Autopsy Findings in the Hatay Region: 274 Cases(De Gruyter Open Ltd, 2012) Hakverdi, Sibel; Guzelmansur, Ismail; Gungoren, Arif; Toprak, Serhat; Yaldiz, Mehmet; Hakverdi, Ali UlviObjective: The aim of this study was to present the incidence of fetal anomalies in our region of Hatay, Turkey in order to determine the efficiency of prenatal diagnosis through fetal autopsy, and to compare our statistical data with other national and international studies. Material and Method: This study was conducted on 274 fetuses from terminated pregnancies due to abnormal prenatal findings and intrauterine deaths from 2005 to September 2010. Fetuses were evaluated through postmortem examination, external measurements, X-rays, Magnetic Resonance Images, Multislice Computerized Tomography and photographs. The autopsy was completed by the histological examination of each organ. Results: Autopsy was conducted on 274 fetuses. A fetal anomaly was detected in 160 (58.39%) cases. The central nervous system contained the most frequent structural defects (79 cases, 49.38%), followed by malformations in the musculoskeletal system in 36 cases (22.5%). The most frequent multiple system anomalies were central nervous system defect and bilateral adrenal agenesis, musculoskeletal system malformations and urinary system defects. Fetal autopsy provided additional findings in 43 cases (26.88%). Conclusion: Fetal autopsy is a very important procedure and an integral part of the general prenatal management. New findings through this method may suggest invaluable data for parents about potential risks in future pregnancies.Öğe Mature cystic teratomas in our series with review of the literature and retrospective analysis(Springer Heidelberg, 2012) Ozgur, Tumay; Atik, Esin; Silfeler, Dilek Benk; Toprak, SerhatMature cystic teratomas are the most common benign ovarian neoplasms. Our aim is to analyse these cases by pathologic and clinical findings in our centre with the view of updated knowledge. In our study, 50 case reports diagnosed as mature cystic teratoma (or dermoid cyst) in Mustafa Kemal University Pathology Laboratory between 2005 and 2010 have been reviewed. Of 50 cases, the findings on mature cystic teratomas were as follows: the number of tumours located at the right ovary was 22, the left ovary, 23, with 5 cases bilaterally. Age range was 14-58 with mean rate 35.4. In two cases, tumour markers were high, one case presented with torsion; one case was obtained incidentally during delivery. Mature cystic teratomas are benign neoplasms with low malign transformation rate. Our series are low in number but our findings show the dynamic nature of these tumours.Öğe Retrospective analysis of basal cell carcinoma(Wolters Kluwer Medknow Publications, 2011) Hakverdi, Sibel; Balci, Didar D.; Dogramaci, Cigdem A.; Toprak, Serhat; Yaldiz, MehmetBackground: Basal cell carcinomas (BCCs) are the most prevalent cancer type among white-skinned populations worldwide. Aims: To analyze the gender and age-related incidence of basal cell carcinoma (BCC) histopathologic subtypes, to classify BCCs according to their anatomical location, invasion depth, and size, and to determine the relationship between BCC subtypes and margin of surgical excision. Methods: All BCCs analysed in our center between 2005 and 2010 were studied retrospectively. The samples, which were totally excised, were included on the basis of histopathological diagnosis of BCC, and confirmed by two pathologists. Patient data included sex, age at diagnosis, tumor location, histological subtypes, invasion depth, and size. Results: We recorded 197 BCCs obtained from 181 white patients (80 females, 101 males). The mean age among males was 64.11, and 59.33 among females. Of the cases, 45.17% were nodular, 22.33% were mixed, and 15.22 were infiltrative type. 91.84% of the cases were located on the head and neck, 3.04% were on the limbs, and 1.52 % were on the trunk. In 32 cases, the margin of surgical excision was positive (17.7%): nodular 12%, infiltrative 43.3%, mixed 20.6%, micronodular 10%, and superfacial multicentric 5.5%. Of these total 32 cases, 34.4% were located on the eyes region, 28.1% were found on the nose, and 15.6% were on the ears. Invasion depth of tumors varied from 0.5 to 22.125 mm. Conclusions: The results of our study exhibit differences in anatomical distribution, sex and mean age, invasion depth, and size of BCC subtypes. The recurrence rate for incompletely excised tumors varies according to the location and type of the tumor. Infiltrative tumors are more likely to recur and have positive margin of surgical excision. The highest positive margin of surgical excision is in infiltrative BCC. Tumors at difficult-to-treat sites and large and/or deeply invasive tumors are more liable to recur.
