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    Design and evaluation of new wound dressings based on collagen-cellulose derivatives
    (Elsevier Sci Ltd, 2023) Tudoroiu, Elena-Emilia; Kaya, Madalina Georgiana Albu; Titorencu, Irina; Dinu-Pirvu, Cristina Elena; Marin, Maria Minodora; Rosca, Ana-Maria; Popa, Lacramioara
    The purpose of this research was to design and characterize new hydrogels, respectively, their lyophilized forms, spongious matrices, based on collagen and methylcellulose or hydroxyethylcellulose to be used as wound dressings. 1.1% collagen gel was blended with 3% cellulose ethers gels in different ratios. To design the new potential dressings, we evaluated the compatibility of biopolymers through rheological and spectroscopic analyses for hydrogels, respectively spectral, morphological, goniometric, enzymatic, and thermal stability. Rheological measurements indicated that all hydrogels were pseudoplastic, a required property for their manipulation and application. Spectroscopic and spectral analyses showed the conservation of the specific triple helix structure of collagen for samples with 30% cellulose ethers. The morphological evaluation demonstrated that matrices presented hydrophilic and porous structures with proper swelling ability. The thermal and biodegradation study illustrated the increase of matrices' stability with the addition of cellulose ethers gels. Biocompatibility tests showed that none of the tested matrices had any cytotoxic effect and some compositions of collagen and methylcellulose or hydroxyethylcellulose release factors that might promote fibroblasts' proliferation and had no inhibitor effect on fibroblasts migration ability; all these results guarantee the development of a promising wound dressing based on 70% collagen gel and 30% cellulose ethers gels.
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    RHEOLOGICAL CHARACTERIZATION OF SOME CELLULOSE DERIVATIVES-BASED HYDROGELS
    (Inst. Nat. Cercetare-Dezvoltare Text. Pielarie, 2022) Tudoroiu, Elena-Emilia; Ghica, Mihaela-Violeta; Albu-Kaya, M?d?lina Georgiana; Dinu-Pîrvu, Cristina-Elena; Popa, L?cr?mioara; Anu?a, Valentina; Velescu, Bruno ?tefan
    Cellulose derivatives serve as a feasible alternative to the insoluble natural cellulose considering their high solubility in the most frequent organic solvents and particularly in water. Alongside this advantageous physical property, cellulose derivatives exhibit proper biocompatibility, biodegradability, thermo-gelling nature, and mechanical characteristics. Due to their high hydrophilicity, these biopolymers possess a great capacity to absorb large amounts of water into their structural chains, forming hydrogels with multiple biomedical applications, such as wound healing. Therefore, the main objective of this present work was to assess the rheological properties of some cellulose derivatives-based hydrogels. For this purpose, different commercial varieties of methylcellulose and hydroxyethylcellulose, two of the most used cellulose derivatives, were dispersed in water and stirred continuously until a clear and transparent hydrogel was formed. Depending on the quantities used of each biopolymer, hydrogels of different concentrations were obtained, from 3 to 20%. The topical semisolid systems were rheologically investigated at 23°C using a rotational viscometer and the rheograms of the experimental data were drawn. The hydrogels showed a non-newtonian pseudoplastic behaviour, which represents a requested requirement for topical semisolid systems, both in terms of conditioning, but also of spreading on the skin surface, improving the topical administration. © 2022 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.