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Öğe ASSESSMENT OF LEFT VENTRICULAR DYSSYNCHRONY IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER(Bmj Publishing Group, 2014) Ustun, N.; Celik, M.; Kurt, M.; Sen, N.; Akcay, A. B.; Turhanoglu, A. D.[Abstract Not Available]Öğe Diffuse osteosclerosis in a patient with prostate cancer(Springer London Ltd, 2014) Ustun, N.; Ustun, I.; Ozgur, T.; Atci, N.; Aydogan, F.; Sumbul, A. T.; Turhanoglu, A. D.A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was -2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.Öğe Effects of habitual knuckle cracking on metacarpal cartilage thickness and grip strength(Elsevier, 2017) Yildizgoren, M. T.; Ekiz, T.; Nizamogullari, S.; Turhanoglu, A. D.; Guler, H.; Ustun, N.; Kara, M.Joint cracking involves a manipulation of the finger joints resulting in an audible crack. This study aimed to determine whether habitual knuckle cracking (KC) leads to an alteration in grip strength and metacarpal head (MH) cartilage thickness. Thirty-five habitual knuckle crackers (cracking their joints >= 5 times/day) (20 M, 15 F, aged 19-27 years) and 35 age-, gender-, and body mass index-matched non-crackers were enrolled in the study. MH cartilage thickness was measured with ultrasound and grip strength was measured with an analog Jamar hand dynamometer. Grip strength was similar between groups (P > 0.05). Habitual knuckle crackers had thicker MH cartilage in the dominant and non-dominant hands than those of the controls (P = 0.038 and P = 0.005, respectively). There was no correlation between MH cartilage thickness and grip strength in both groups (P > 0.05). While habitual KC does not affect handgrip strength, it appears to be associated with increased MH cartilage thickness. (C) 2016 SFCM. Published by Elsevier Masson SAS. All rights reserved.Öğe PRECLINICAL ATHEROSCLEROSIS IN PATIENTS WITH ANKYLOSING SPONDYLITIS WITHOUT CLINICALLY EVIDENT CARDIOVASCULAR DISEASE(Bmj Publishing Group, 2014) Turhanoglu, A. D.; Ustun, N.; Kurt, M.; Yagiz, A. E.; Guler, H.[Abstract Not Available]Öğe The relationship between anti-cyclic citrullinated peptide and bone mineral density and radiographic damage in patients with rheumatoid arthritis(Taylor & Francis Ltd, 2008) Guler, H.; Turhanoglu, A. D.; Ozer, B.; Ozer, C.; Balci, A.Objectives: We aimed to investigate the relationship between anti-cyclic citrullinated peptide (anti-CCP) levels and bone mineral density (BMD), bone turnover, and radiographic damage in patients with rheumatoid arthritis (RA). Methods: Eighty patients (68 females, 12 males, mean age 46.50 +/- 14.59 years) with RA were included in the study. Anti-CCP antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Bone turnover was studied by analysing serum levels of C-terminal telopeptide of type I collagen (sCTX, ng/mL), using an enzyme immunoassay. BMD was measured by dual-energy X-ray absorptiometry (DXA). Disease activity was assessed according to the Disease Activity Score that includes 28 joint counts (DAS28). Functional capacity was assessed by the Health Assessment Questionnaire (HAQ). Results: Anti-CCP-positive patients were defined as group 1 and anti-CCP-negative patients as group 2. The mean disease duration was 7.53 +/- 6.27 years in group 1 and 6.25 +/- 6.51 years in group 2. Anti-CCP had a limited negative correlation with lumbar BMD (r=-0.220, p=0.050) and a negative correlation with femoral BMD (r=-0.242, p=0.031). There was no statistically significant correlation between anti-CCP and sCTX values (r=0.117, p=0.301). Sharp scores were significantly higher in anti-CCP-positive than anti-CCP-negative patients (p=0.012), and anti-CCP levels were significantly correlated with Sharp scores (r=0.240, p=0.032). Conclusions: We found that RA patients with higher levels of anti-CCP antibody had lower lumbar and femoral BMD. Anti-CCP levels were also associated with radiographic damage. Therefore, we suggest that anti-CCP may be a determinant of bone loss in patients with RA.Öğe SUBCLINICAL LEFT VENTRICULAR DYSFUNCTION IN PATIENTS WITH ANKYLOSING SPONDYLITIS WITHOUT CLINICALLY EVIDENT CARDIOVASCULAR DISEASE: A TWO-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHIC STUDY(Bmj Publishing Group, 2014) Ustun, N.; Kurt, M.; Yagiz, A. E.; Guler, H.; Turhanoglu, A. D.[Abstract Not Available]
