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    The Determination of Oxidative Stress by Paraoxonase Activity, Heat Shock Protein and Lipid Profile Levels in Cattle with Theileriosis
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2012) Turunc, Vecihe; Askar, Tunay Kontas
    Theileriosis is a common illness that cause large economic losses. The aim this study was to define the oxidative status by determining the changes in levels of malondialdehyde, heat shock protein, paraoxonase activity and lipid profile (triglycerides, total cholesterol, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein) in cattle with tropical theileriosis. In the study, 15 healty cattle and 15 cattle with tropical theileriosis, between 1-3 years old, were used. Plasma malondialdehyde (P<0.001) and heat shock protein 27 (P<0.01) levels were determined significantly higher in cattles with Theileriosis than the control group. On the other hand, serum paraoxonase level was significantly lower than the control group. According to lipid profile analyses, while serum trigliserid (P<0.001) and very low-density lipoprotein (P<0.01) levels were found significantly higher in cattles with theileriosis, serum total cholesterol (P<0.001), low-density lipoprotein (P<0.001) and high-density lipoprotein (P<0.001) levels were found significantly lower in cattles with theileriosis than the control group. In conclusion, serum lipid profile could play role in pathogenesis of theileriosis because of the biochemical changes, such as degeneration of liver and increased levels of lipolysis for compansate the energy requirement which was increased due to theileriosis. In addition, determination of serum paraoxonase activity and heat shock protein 27 levels may be useful tools in the determination of oxidative stress in tropical theileriosis.
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    Öğe
    Heat shock proteins and their physiological roles
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2007) Askar, Tuenay Kontas; Ergun, Nuray; Turunc, Vecihe
    Heat shock proteins (HSPs), also called stress proteins, are a group of proteins that are present in all cells in all life forms. The synthases of these proteins are induced when a cell undergoes various types of environmental stresses like heat, cold and oxygen deprivation. In this article we summarized the structure and physiology of heat shock proteins which is an important research area for biology and medicine.