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    Öğe
    The effect of Theranekron® in intact and ischemia-reperfusion injured rat ovary
    (2023) Güler, Fatma; Kozlu, Tolunay; Ergün, Yaşar; Alan, Beyza Suvarıklı; Tutar, Tolga
    The effect of Theranekron® on ovaries were evaluated in healthy and ischemia- reperfusion injury rat model. Thirty-eight female, nulligravida Wistar Albino rats were divided into four groups, as follows: group 1: control, group 2: Theranekron®, group 3: ischemia-reperfusion and group 4: ischemia-reperfusion+Theranekron®. Each groups were analyzed biochemically and histologically. As compared with group 1, there was a significant increase in the number of atretic follicles and interstitial cells in group 2. Also, nitrite, nitrate, and malondialdehyde levels increased significantly in group 2. Group 3 represented intense hyperemia and hemorrhages on follicles surrounding the cortex and in the corpus luteum and marked increase in the number of atretic follicles, compared to group 2. Nitrite and nitrate levels in group 3 were similar to those in group 2, but malondialdehyde levels were lower than those in group 2. Group 4 showed very slight decrease in interstitial cells compared with group 2 and group 3. In this group, malondialdehyde levels decreased compared to group 2 and increased compared to control and group 3. Based on the results obtained, we may speculate that Theranekron® may have some degenerative effects on intact ovaries, and may have ameliorating effects on ischemia reperfusion injury in ovaries.
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    Öğe
    Morphology of septomarginal trabeculae in Hatay mountain gazelle (Gazella gazella)
    (Wiley, 2022) Erdem, Baran; Tutar, Tolga; Takci, Lutfi; Bozkurt, Yesim Akaydin; Ates, Sevinc
    This study was conducted to reveal the anatomical and histological features of left and right septomarginal trabeculae in the heart of the Hatay mountain gazelle. In the study, two female and two male adult Hatay mountain gazelle hearts were used. For this purpose, the materials detected in 10% formaldehyde solution were stained with Crossman's modified triple staining technique and examined under a light microscope after anatomical examinations and measurements were made. The presence of trabeculae in both ventricles was demonstrated. While the number of septomarginal trabeculae was 1 in each of the samples in the right ventricle, it was determined that it was 2 in each of three hearts and 3 in one heart in the left ventricle. It was observed that the right trabeculae were unbranched and fleshy, while the left trabeculae were filamentous and mostly branched. The lengths and thicknesses of the right trabeculae were measured 12-17 mm and 3-4 mm and the lengths and thicknesses of the left trabeculae were measured 6-15 mm and 0.5-1 mm. In the histological examination of both trabeculae, connective tissue, Purkinje fibres and blood vessels were observed, in addition, it was detected that the right trabeculae had myocardial fibres. Few capillaries were found in the left trabecula, while both more capillaries and blood vessels were found in the right trabeculae.