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Öğe Ameliorating effect of quercetin on acute pentylenetetrazole induced seizures in rats(E-Century Publishing Corp, 2014) Sefil, Fatih; Kahraman, Ibrahim; Dokuyucu, Recep; Gokce, Hasan; Ozturk, Atakan; Tutuk, Okan; Aydin, MehmetObjective: The aim of the study to elicit effects of pure quercetin in pentylenetetrazole (PTZ) and picrotoxin induced seizures. Materials and methods: Each animal group was divided into six groups and composed of six rats. Rats were assigned to the following experiments and groups (G): (G1) PTZ 45 mg/kg + DMSO; (G2) PTZ 45 mg/kg + 5 mg/kg quercetin; (G3) PTZ 45 mg/kg + 10 mg/kg quercetin; (G4) PTZ 45 mg/kg + 20 mg/kg quercetin; (G5) PTZ 45 mg/kg + 40 mg/kg quercetin; (G6) Picrotoxin 5 mg/kg + DMSO; (G7) Picrotoxin 5 mg/kg + 10 mg/kg quercetin; (G8) Picrotoxin 5 mg/kg + 20 mg/kg quercetin. In all groups quercetin were injected 30 min before PTZ and picrotoxin applications. Results: Compared to PTZ, quercetin significantly prolonged onset of the seizure in 10 mg/kg (P < 0.05) and reduced the seizure stage in 10 mg/kg quercetin injected group (P < 0.01). Compared to PTZ, quercetin also declined the generalized seizure duration at 10 mg/kg (P < 0.01) and 20 mg/kg (P < 0.05) doses. At the doses of 5 mg/kg and 40 mg/kg quercetin there were no significant changes in seizure parameters. Development of picrotoxin induced seizures is slower than in PTZ. Quercetin was found to be unable to prevent seizure in picrotoxin induced seizures. Surprisingly, quercetin also significantly reduced the onset of seizures at the dose of 20 mg/kg (P < 0.05). Conclusion: quercetin (at doses of 10 and 20 mg/kg i.p) prevented seizures in PTZ (45 mg/kg i.p) induced seizures. Especially, 10 mg/kg PTZ prolonged onset of seizures, reduced the seizure duration and seizure severity score in comparison with control group. At a higher (40 mg/kg) dose quercetin failed to prevent PTZ induced seizures. In addition 20 mg/kg quercetin significantly reduced the onset of seizures that suggest a preconvulsive effect. 20 mg/kg quercetin reduced the onset of picrotoxin induced seizures. In picrotoxin model, it may be claimed that quercetin at higher doses accelerate the epileptic activity owing to its antagonistic effect on GABAA. Further investigations are needed to explore the mechanisms of the antiepileptic and preconvulsant effects of quercetin.Öğe The Amelorative Role of Thymoquinone on a Rat Model of Letrozole-Induced Polycystic Ovary Syndrome(Wiley-Blackwell, 2015) Dokuyucu, Recep; Ozgur, Tumay; Dogan, Hatice; Tutuk, Okan; Tas, Zeynel Abidin[Abstract Not Available]Öğe Anticonvulsive and behavior modulating effects of sophoretin and rutoside(Akademiai Kiado Zrt, 2019) Demir, Enver Ahmet; Ozturk, Atakan; Tutuk, Okan; Dogan, Hatice; Tumer, CemilIntroduction: Seizures are the hallmarks of most types of epilepsies. Behavioral and cognitive impairments coincide with interictal periods even though it is not clear whether these impairments spring out of the seizure itself or accompanying sociopsychological burden of the disease. Materials and methods: In this study, we investigated behavioral and cognitive consequences of a single GABA receptor-related seizure in mice, and examined the potential anticonvulsive and behavior-modulating properties of sophoretin (quercetin) and rutoside (rutin). Results: The study demonstrated that sophoretin and rutoside, common flavonoids of the human diet, delay the seizure onset and reduce the seizure stage. Moreover, they exerted an antidepressant-like effect, which was independent of the seizure. Neither treatments nor seizure altered recognition and spatial memory performances of the mice. Conclusions: Behavioral or cognitive disturbances that are evident in epileptic patients did not appear following a single seizure. In addition, we suggest that both sophoretin and rutoside successfully alleviate the seizure severity without interfering in the behavioral stability and cognitive performance. Hence, these flavonoids may be of use as adjuncts to the current treatment options.Öğe Assessment of Sensitivity to the Anesthesia in a Diabetic Rat Model(Wiley-Blackwell, 2015) Dokuyucu, Recep; Dogan, Hatice; Agturk, Gokhan; Cay, Emrah; Bilgic, Yasemin; Egeli, Duygu; Tutuk, Okan[Abstract Not Available]Öğe Behavioral and Cognitive Consequences of Obesity in Parents and Offspring in Female and Male Rats: Implications of Neuroinflammation and Neuromodulation(Springer, 2022) Demir, Enver Ahmet; Gulbol-Duran, Gulay; Urhan-Kucuk, Meral; Dogan, Hatice; Tutuk, Okan; Cimen, Funda; Bayirli, MucellaObesity is a rapidly growing public health concern that can create a family-wise burden. This study was aimed to investigate behavioral, cognitive, neuroinflammatory, and neuromodulatory consequences of the diet and parental obesity. Female and male Wistar albino rats were fed on either an obesogenic or standard diet for 12 weeks, beginning with weaning. Thereafter, the animals were matched and allowed to mate. Pups born to obese or normal parents received either the diet or standard chow to the same age. The obesogenic diet and/or parental obesity increased the locomotor activity in both females and males. The diet exhibited anxiolytic-like and antidepressant-like properties, and impaired short-term object memory as well as spatial memory. Interestingly, the obesogenic diet resulted in neuroinflammation only in naive animals, but not in the ones with parental obesity. BDNF, SIRT1, and p53 expressions were decreased, whereas RelN expression was increased in the brain with the diet, regardless of parental obesity. Multi-factor analyses demonstrated that the obesogenic diet is the prominent influencer of cognitive, neuroinflammatory, and neuromodulatory results while parental obesity has an effect on spatial memory, neuroinflammation, and hippocampal RelN and p53 expressions. Here, we provided supporting evidence for detrimental cognitive and neuroinflammatory consequences of early life consumption of the obesogenic diet which accompanies alterations in neuromodulatory factors. Surprisingly, the diet was found beneficial against anxiety-like and depression-like behaviors, and additionally, parental obesity was demonstrated to impair some aspects of cognitive performance which appears unrelated to neuroinflammation.Öğe Capparis Spinosa L. in an Animal Model of Sciatic Crush Injury(Wiley, 2019) Ishakoglu, Ozlem Kutlu; Tutuk, Okan; Dogan, Hatice; Demir, Enver Ahmet; Secinti, Ilke Evrim; Kara, Mikail; Kahraman, Ibrahim[Abstract Not Available]Öğe The Comparison of Visceral Adiposity Measures Between Type 2 Diabetics and Healthy Individuals(Wiley, 2018) Egeli, Duygu; Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Acik, Murat; Tumer, Cemil[Abstract Not Available]Öğe CREB1 and PPAR-?/? Pathways in Hepatic Ischemia/Reperfusion: Route for Curcumin to Hepatoprotection(Briefland, 2022) Demir, Enver Ahmet; Tutuk, Okan; Dogan-Gocmen, Hatice; Ozyilmaz, Duygu Seren; Karagul, Meryem Ilkay; Kara, Mikail; Temiz, MuhyittinBackground: Hepatic ischemia/reperfusion injury is a major problem that can exacerbate complications, particularly in liver trans-plantations. Objectives: This study aimed to investigate the cellular mechanisms of ischemia/reperfusion injury and hepatoprotection by cur -cumin. Methods: Wistar albino rats were divided into four groups as Control, Sham, I/R, and Cur+I/R. Hepatic ischemia/reperfusion was induced in I/R and Cur+I/R animals, the latter of which was also given 50 mg/kg/day of curcumin for 14 days. Liver aminotransferases and the transcription regulators of inflammation (RelA, I & kappa;B, PPAR-& alpha;, PPAR-& gamma;, CREB1) were examined along with the histological examination. Results: Hepatic ischemia/reperfusion was found to disrupt hepatic microstructure and downregulate PPAR-& alpha;, PPAR-& gamma;, and CREB1 transcripts. Curcumin supplementation in hepatic ischemia/reperfusion recovered the structural organization and promoted the hepatocyte regeneration while increasing expressions of PPARs and CREB1. RelA and I & kappa;B were found unaltered, possibly due to the crosstalk between targeted transcripts by ischemia/reperfusion and curcumin. Conclusions: In sum, PPAR-& alpha;/& gamma; and CREB1 were involved in hepatic ischemia/reperfusion and, moreover, were detected to be stim-ulated by curcumin. PPAR and CREB pathways were found to provide a route to hepatoprotection for curcumin supplementation as evidenced by the microstructural improvement.Öğe Determining the Ideal Object Size in the Novel Object Recognition Test(Wiley, 2019) Kasirga, Busra; Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Tumer, Cemil[Abstract Not Available]Öğe Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer's disease(Nencki Inst Experimental Biology, 2018) Bilgic, Yasemin; Demir, Enver Ahmet; Bilgic, Nilufer; Dogan, Hatice; Tutuk, Okan; Turner, CemilPolyphenols and omega-3 fatty acids are thought to have beneficial effects in Alzheimer's disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum-induced Alzheimer's disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt's forced swim, and Morris' water maze, to evaluate anxiety- and depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer's-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment. Rather, cognitive performance in chia-pretreated animals was remarkably worse as compared to their non-treated disease-induced counterparts. Hippocampal concentrations of amyloid-beta 42, amyloid precursor protein, and total tau protein were similarly increased in all disease-induced animals (despite chia supplementation), as compared to the controls. Based on these findings, chia supplementation during the progression of Alzheimer's disease may exacerbate the disease. Although the results presented here emerge from an experimental/preclinical study, we suggest cautious and careful use of chia, especially in early-stage Alzheimer's patients, until future research in different experimental settings is conducted.Öğe Effect of Alpha-LipoicAcid on TRPM7 Gene Expression in Experimental Varicocele Model(Wiley, 2018) Tutuk, Okan; Dogan, Hatice; Demir, Enver Ahmet; Tutuk, Sumeyye; Tumer, Cemil[Abstract Not Available]Öğe The Effect of Caffeic Acid Phenethyl Ester (CAPE) on TRPM 2, 8 Channels in Hepatic Ischemia-Reperfusion Model(Wiley-Blackwell, 2016) Dokuyucu, Recep; Dogan, Hatice; Tutuk, Okan; Sefil, Fatih; Gogebakan, Bulent; Gokce, Hasan; Tumer, Cemil[Abstract Not Available]Öğe The Effect of Chia (Salvia hispanica L.) Seed in an Experimental Alzheimer's Disease Model(Wiley, 2018) Bilgic, Yasemin; Demir, Enver Ahmet; Bilgic, Nilufer; Dogan, Hatice; Tutuk, Okan; Tumer, Cemil[Abstract Not Available]Öğe Effect of thymoquinone on transient receptor potential melastatin (TRPM) channels in rats with liver ischemia reperfusion model in rats(Mashhad Univ Med Sciences, 2024) Caglar, Kerem; Dokuyucu, Recep; Agturk, Gokhan; Tumer, Cemil; Tutuk, Okan; Gocmen, Hatice Dogan; Gokce, HasanObjective(s): We aimed to investigate the levels of transient receptor potential melastatin (TRPM) gene expression, and the antioxidant and histopathologic effect of thymoquinone (Tmq) in the hepatic I/R rat model. Materials and Methods: Fifty Wistar rats were divided into 5 groups. Group 1: Control; Group 2: Sham; Group 3: Hepatic I/R (45 min/45 min); Group 4: Tmq (50 mg/kg); Group 5: Tmq+I/R (ten days before I/R at the dose of 50 mg/kg of Tmq). The hepatic I/R (45min/45min) model was performed at the portal vein and the hepatic artery with atraumatic vascular clamp in the ischemia groups. The liver tissues and blood samples that were taken at the end of the study were evaluated for histopathologic and biochemical analysis. Besides TRPM gene expression levels were determined in liver tissues. It was seen that cellular swelling, congestion, PNL, and apoptosis parameters statistically decreased in Tmq and Tmq+I/R groups in comparison with the I/R group in histopathological evaluation. Results: It was observed that biochemical parameters, AST, ALT, GGT, LDH, creatinine, and urea levels significantly increased in the I/R group as compared with, sham, Tmq, and Tmq+I/R groups. It was found that TRPM2,6,7,8 gene expression decreased significantly in Tmq+I/R groups as compared to the I/R group. Conclusion: We showed that thymoquinone can inhibit the entry of Ca+2 into the cell by decreasing TRPM2,6,7,8 gene expression. Based on our findings, we think that Tmq application in the treatment of liver diseases due to I/R damage may be important in terms of both ischemia and apoptosis and can also be used in the treatment of liver-related diseases.Öğe The Effect of Vitamin D in an Experimental Varicocele Model(Wiley, 2018) Agturk, Gokhan; Demir, Enver Ahmet; Tutuk, Okan; Dogan, Hatice; Ozgur, Tumay; Tumer, Cemil[Abstract Not Available]Öğe Effect of vitamin D in experimental varicocele model in rats(Cukurova Univ, Fac Medicine, 2024) Agturk, Gokhan; Tumer, Cemil; Tutuk, Okan; Gocmen, Hatice Dogan; Ozgur, Tumay; Ozcan, Oguzhan; Duran, Gulay GulbolPurpose: Varicocele is a pathological condition that affects approximately 20% of adult men, causing infertility and sperm deterioration. The aim of our study was to investigate the efficacy of vitamin D (Vit. D) in the pathophysiology of varicocele. We performed biochemical, gene expression analyses and histopathological to evaluate the efficacy of vitamin D in the experimental varicocele model. Materials and Methods: In the study, 30 adult male Wistar Albino rats were used. The rats were divided into 3 groups equally as control group, experimental group (varicocele), treatment group (varicocele + D vit.). The treatment group received 500 IU/kg D vit. intramuscularly. Results: Histopathological, TRPM2-8 gene expression and biochemical analyses were performed on testicular and blood samples collected at the end of the experiment. The experimental group showed a deterioration in tubular structure, a decrease in total antioxidant levels and an increase in total oxidant levels. The treatment group, on the other hand, showed an increase in TAS, a decrease in TOS and a beneficial improvement in tubular structure disorders. Analysis of gene expression levels showed that TRPM2-8 expression levels were significantly increased in the varicocele group and decreased in the treatment group. Conclusion: In the varicocele model, the use of vitamin D had a significant effect on TRPM2-8 gene level, pathological seminiferous tubules and biochemical values. Further studies are needed to determine the clinical application of vitamin D in varicocele disease.Öğe Effects of Alpha-Lipoic Acid on Urotensin II and TGF-?1 on Steroid-induced Osteonecrosis in Rats(Wiley-Blackwell, 2016) Dokuyucu, Recep; Tutuk, Okan; Dogan, Hatice; Bilgic, Nilufer; Tas, Zeynel Abidin; Sefil, Fatih; Gogebakan, Bulent[Abstract Not Available]Öğe Effects of Erdosteine and Vitamin D in Experimental Rat Kidney Ischemia/Reperfusion Model(Wiley, 2017) Dogan, Hatice; Demir, Enver Ahmet; Tutuk, Okan; Ozgur, Tumay; Kucuk, Meral Urhan; Ozcan, Oguzhan; Bayraktar, Suphi[Abstract Not Available]Öğe The Effects of Erdosteine and Vitamin D on Liver Damage After Renal Ischemia Reperfusion(Wiley, 2017) Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Ozcan, Oguzhan; Ozgur, Tumay; Tumer, Cemil[Abstract Not Available]Öğe The Effects of Erdosteine and Vitamin D on TRPM 2 Ion Channel in Renal Ischemia Reperfusion Damage Model in Rats(Wiley, 2018) Dogan, Hatice; Tutuk, Okan; Demir, Enver Ahmet; Tumer, Cemil[Abstract Not Available]
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