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Yazar "Tutun, Hidayet" seçeneğine göre listele

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    Concentration of essential and non-essential elements and carcinogenic/non-carcinogenic health risk assessment of commercial bee pollens from Turkey
    (Elsevier Gmbh, 2023) Sevin, Sedat; Tutun, Hidayet; Yipel, Mustafa; Aluc, Yasar; Ekici, Husamettin
    Background: Bee pollen, known as a natural super-food with valuable nutritional ingredients, is regarded as a good indicator of ecotoxic substances, such as potentially toxic elements (PTEs). Therefore, this study aims to examine the concentrations of selected PTEs (Al, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Mo, Ni, Pb, Se, Sn, Sr, V, Zn) in bee pollen purchased from online markets in Turkey and perform a health risk assessment to identify the potential risk to consumers.Methods: The quantitative analyses were conducted by inductively coupled plasma optical emission spectrometry (ICP-OES).Results: The mean values of essential PTEs in decreasing content order were Mg > Fe > Zn > Mn > Cu > Ni > Se > Cr > Mo >Co = V. Regarding the results of the study, daily consumption (40 g for adult or 20 g for children) of commercial bee pollen can recompense 20-35 % of daily Cu, Mn, Se requirements for children, adults, pregnant, and breastfeeding women. The decreasing content order of non-essential elements was Al > Sn > Sr > Ba > Pb > As. Cadmium and Hg concentrations were below the detection limits in all the samples. In terms of food and public health; detection of the PTEs concentrations is necessary to assess the quality and safety of bee pollen before consumption. According to the carcinogenic and non-carcinogenic risk assessments; commercial pollen consumption does not pose a health risk to either children or adults for the PTEs monitored in this study.Conclusion: We conclude that bee pollen is an ideal indicator for the monitoring of environmental pollution of PTEs and also a valuable source of essential elements. This study highlights the need to develop standards that regulate acceptable concentrations of PTEs.
  • [ N/A ]
    Öğe
    The content and health risk assessment of selected elements in bee pollen and propolis from Turkey
    (Academic Press Inc Elsevier Science, 2022) Tutun, Hidayet; Aluc, Yasar; Kahraman, Hatice Ahu; Sevin, Sedat; Yipel, Mustafa; Ekici, Husamettin
    This study aimed to determine the concentrations of potentially toxic elements (PTEs), including Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se, Sn, V, and Zn, in pollen and propolis samples collected from migratory beekeeping areas in Turkey. A health risk assessment was performed to identify the potential risk of these PTEs to consumers in terms of public health. Concentrations of the elements were analyzed by inductively coupled plasma optical emission spectroscopy. The most abundant element in the bee pollen and propolis samples was Fe, with average concentrations of 47.3 and 390 mg kg(-1), respectively, followed by Al, Zn, Mn and Sn. Concentrations of all elements except Cu, Mn and Sn were higher in propolis than in pollen. The concentrations of Fe, Al, and Zn in the propolis samples were over eight, seven, and two times higher than in the bee pollen samples, respectively. Se, Cd, and Hg in pollen and Se and Cd in propolis were below the detection limits. Pb, Co, and Cr were detected below 0.62, 0.06, and 0.91 mg kg(-1), in pollen samples, respectively. Co and Hg were detected below 0.68, and 0.18 mg kg(-1), in propolis samples, respectively. Detection of the PTEs contamination level and assessment of the health risks in pollen and propolis is necessary to ascertain quality and safety before consumption. In this study, we concluded that bee pollen and propolis may be good indicators for the screening of environmental pollution with PTEs and standards regulating acceptable concentrations of these pollutants in bee products should be established. In addition, it has been determined that consumption at the specified rates does not pose a risk. This study suggests the determination of admissible concentrations of PTEs in bee pollen and propolis.
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    Küçük Resim
    Öğe
    Investigating of Effects of Metformin on Melanoma Skin Cancer
    (2021) Alp, Harun; Tutun, Hidayet; Altıntaş, Levent; Kaplan, Halil Mahir; Şingirik, Ergin; Kahraman, İbrahim
    Aim: Apoptotic pathways are important for resistance to chemotherapeutics drugs and cancer development. Metformin is a safe, inexpensive and effective drugused to treat type 2 diabetes. Furthermore, although there is evidence of anticancer effects, the mechanisms by which metformin exerts the effects are unclear.Therefore, it was aimed to investigate Bcl-2, kaspaz-3, bax, wee-1, AIF, grp78 and gadd153 levels in metformin treated skin cancer cells. Materials and Methods: The skin cancer cells (B16F10) were treated with metformin and kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF levels were analyzedby using ELISA. Result: Treatment of metformin increased of proapoptotic proteins (kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF) and decreased antiapoptotic protein (bcl 2). Conclusion: In conclusion, this study showed that metformin has apoptotic effect on melanoma skin cancer.
  • Yükleniyor...
    Küçük Resim
    Öğe
    Investigation of apoptotic effects of hypericum perforatum extract on breast cancer cell line
    (Harran Üniversitesi, 2019) Alp, Harun; Tutun, Hidayet; Kaplan, Halil Mahir; Şıngırık, Ergin; Altıntaş, Levent
    Abstract: Hypericum perforatum has biological active contents affecting a variety of proteins such as caspase-3, bcl-2, and bax, which mediate apoptosis known as programmed cell death and exerting anti-inflammatory effect. Apoptotic pathways are important for cancers, chemotherapeutic resistance, and cancer development. Anti-inflammatory agents are also a potential target for cancer. Therefore, it was aimed to investigate the activity of caspase-3 and the expressions of bcl-2, bax, wee 1, gadd153, grp78, AIF, iNOS, COX-2, cPLA2, and NF-κB in H. perforatum extract-treated breast cancer (BC) cells in this study. The activity of caspase-3 and the expressions of these proteins were determined in the cells by ELISA. The HP extract increased the activity of caspase-3 and the expressions of bax, wee 1, gadd153, grp78 and AIF, and decreased the expressions of bcl-2, COX-2, iNOS, cPLA2 and NF-κB in the BC cells. In the light of these findings, HP extract could help to inhibit grow of BC cells and its anti-inflammatory effect may contribute this effect.
  • [ N/A ]
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    Phenolic acids as potent antioxidant agents
    (Elsevier, 2024) Tutun, Hidayet; Yipel, Mustafa
    Phenolic acids comprise a class of phytochemical compounds found mainly in fruits, legumes, vegetables, tea, wine, and coffee in free, conjugated-soluble, and insoluble-bound forms. The use of these plants in phytomedicine is mostly related to their biological activities such as antiinflammatory, antiviral, antimicrobial, anticancer, and wound healing properties. Phenolic acids are the main source of dietary antioxidants and considered as important bioactive compounds on account of many health benefits along with their pivotal role in delaying oxidative rancidity of numerous foods. Numerous studies have focused on antioxidant activity of phenolic acids, which is due to their ability to reduce the free radical formation and for scavenging free radicals. The antioxidant activities of phenolic acids are related with the phenolic hydroxyl groups (phenyl-O-glucuronides, etc.) attached to the ring structures. Among phenolic acids, ferulic and caffeic acids become prominent as potent antioxidant agents. © 2024 Elsevier Inc. All rights reserved.

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