Yazar "Ucar, E." seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Changes in liquid emptying in migraine patients: diagnosed with liquid phase gastric emptying scintigraphy(Wiley, 2012) Yalcin, H.; Okuyucu, E. E.; Ucar, E.; Duman, T.; Yilmazer, S.Gastric stasis is suspected mostly to be encountered during acute migraine attack. The aim of this study is to evaluate the liquid phase gastric emptying and motility in migraine patients in ictal and interictal periods in comparison to normal subjects with gastric emptying scintigraphy. Seven women with migraine and age, sex matched controls who applied to the Neurology Department from May 2009 to May 2010 were compared. Gastric emptying study with a standard liquid was performed one time in the non-migraineur group and two times in the migraineur group. Non-migraineur controls and migraineurs were compared. The mean T1/2 was longer in ictal period in migraineurs. The T1/2 of migraineurs interictally and the control groups were similar. The T1/2 of migraineurs ictally and migraineurs interictally were also compared. We also considered the percentage of the radioactive material remaining in the stomach. There were no significant differences between non-migraineurs and migraineurs interictally. However, increased amount of radioactive material remaining in the stomach was observed in migraineurs ictally. We concluded that the liquid emptying was delayed in spontaneous migraine attacks in migraine without aura, however in the interictal period the emptying of liquids did not differ between migraineurs and non-migraineurs.Öğe Community-acquired urinary tract infections in Southern Turkey: etiology and antimicrobial resistance(Dustri-Verlag Dr Karl Feistle, 2009) Cetin, M.; Ucar, E.; Guven, O.; Ocak, S.In this study, we compared the distribution and antibiotic susceptibility patterns of bacterial strains isolated from patients with community-acquired urinary tract infections in Southern Turkey, Hatay, during 2004 and 2005. The majority (82.3%) of the isolates were from women while the remaining (17.7%) were from men. Of all samples tested, 49% were culture-positive with a bacterial pathogen. The most frequently isolated bacterial species were Escherichia coli (45.1%), coagulase-negative Staphylococcus (CNS) (15.5%) and Klebsiella spp. (10.9%). E. coli was more prevalent in women (p < 0.05) while Klebsiella spp., Proteus spp. and Pseudomonas spp. were found more prevalent in men (p < 0.05). Increasing resistance to gentamicin, amikacin and cefazolin, and decreased resistance to ciprofloxacin, ofloxacin, levofloxacin and cotrimoxazole were observed in E. coli isolates over the 2 years. While the lowest resistance rates for E. coli occurred in 2004 (26.0%) and 2005 (20.5%) for cefuroxime, the highest resistance rates occurred in 2004 (81.3 and 47.9%) and 2005 (61.3 and 49.6%) for ampicillin and amoxicillin-clavulanate, respectively. The results of this study stress that antibiotic usage policies, especially empirical therapies, should be based on antimicrobial resistance surveillance studies.Öğe Effect of phosphodiesterase-5 inhibitor on hearing(Cambridge Univ Press, 2009) Okuyucu, S.; Guven, O. E.; Akoglu, E.; Ucar, E.; Dagli, S.Objective: Following a report of sudden hearing loss in a patient taking phosphodiesterase type 5 inhibitor, and a Food and Drug Administration announcement concerning this class of drugs, a study was planned to investigate if ototoxicity occurs in patients using phosphodiesterase 5 inhibitor for erectile dysfunction. Methods: Eighteen patients with erectile dysfunction who had been using phosphodiesterase 5 inhibitor were included in the study. Audiometric tests were performed on all patients, between the frequencies 250 and 16 000 Hz, before and 1, 5 and 72 hours after drug ingestion. Results: Four patients showed a unilateral threshold decrease compatible with ototoxicity criteria; this change was reversible. A statistically significant difference in pre- versus post-drug hearing thresholds was observed in the right ear at 10 000 Hz (p = 0.008). There were no statistically significant hearing threshold differences at any other frequencies (p > 0.05). Conclusion: Although temporary ototoxicity was noted in four patients, we could not find any permanent, deleterious effect of phosphodiesterase type 5 inhibitor on hearing thresholds.Öğe The Effects of Interferon ?2b on Chemically-induced Peritoneal Fibrosis and on Peritoneal Tissue MMP-2 and TIMP-2 Levels in Rats(Field House Publishing Llp, 2010) Ucar, E.; Borazan, A.; Semerci, E.; Binici, D. N.; Yaldiz, M.; Aysal, A.; Altug, E.This study investigated the effect of interferon alpha 2b on chlorhexidine gluconate (CH)-induced peritoneal fibrosis (PF) in rats and assessed peritoneal tissue levels of metalloproteinase (MMP)-2 and tissue inhibitors of metalloproteinases (TIMP)-2. Wistar albino rats (n = 8 per group) were treated as follows: control group, 3 ml/day of 0.9% saline intraperitoneally for 28 days; CH group, 0.1% CH (200 g [3 ml]/day) in 15% ethanol and 0.9% saline intra-peritoneally for 28 days; CH + interferon (IFN) group, CH (as above) plus pegylated IFN-alpha 2b 1.5 mu g/kg per week subcutaneously on days 0, 7, 14, 21 and 28; IFN group, pegylated IFN-alpha 2b (as above). Parietal peritoneum samples were obtained from the left anterior abdominal wall after 35 days. Parietal thickness, degree of vascular proliferation and inflammation, and MMP-2 and TIMP-2 levels were determined. The mean peritoneal thicknesses of the control, CH, CH + IFN and IFN groups were 7.02 +/- 3.89, 156.86 +/- 29.13, 59.88 +/- 22.1, 9.27 +/- 2.03 mu m, respectively. Pegylated IFN-alpha 2b decreased CH-induced expression of MMP-2 in the parietal peritoneum, but had no effect on TIMP-2 levels. Further studies are needed to determine the optimal dosage and duration for pegylated IFN-alpha 2b treatment.Öğe Epidemiology and cost of burns in emergency department during Syrian civil war(Comenius Univ, 2018) Kuvandik, G.; Ucar, E.; Karakus, A.BACKGROUND: We aimed to emphasize the importance of regional hospitals' capacities and emergency services for burn patients in war and disaster situations, in addition to assessing the costs and clinical situations of seriously burned patients who have come to the emergency service due to the bomb and heater burst during the Syrian civil war. METHODS: In this study, we analyzed these 217 burn patients and analyzed these patients' data for retrospective analysis. RESULTS: Burn patients were more often seen during the winter months. The majority of the patients were children, young adults and male (1-16 age, 95 % burn, 44 %, 17-40 age 94 % burn, 44 %, >= 41-65 age, 28 % burn, 12 %). The most common body surface burns >= 20 % body surface in surviving patients n = 184, 78 % were determined. 14 of the burned patients died within the first 24 hours. The total cost of the burned patients in the emergency unit was observed to be 33.4 +/- 25.9 Turkish Lira (10.2-6813.2). CONCLUSION: The present study showed that burn patients need much longer treatment time. The need for trained personnel in case of mass disasters and warfare, the identification of burn intensive care units and hospitals to be referred is important (Tab. 2, Fig. 4, Ref. 23). Text in PDF www.elis.sk.Öğe Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis(Wiley, 2009) Balci, D. D.; Balci, A.; Karazincir, S.; Ucar, E.; Iyigun, U.; Yalcin, F.; Seyfeli, E.Psoriasis is associated with an increased risk of atherosclerosis. This study compared subclinical atherosclerosis of the carotid and brachial arteries in psoriasis vulgaris patients and healthy controls using high-resolution ultrasonography. We studied 43 psoriasis patients and 43 healthy controls matched for age and sex. Flow-mediated dilatation (FMD) and nitroglycerin-induced dilatation (NTD) of the brachial artery and intima-media thickness (IMT) of the common carotid arteries (CCA) were measured ultrasonographically. Diabetes mellitus, hypertension, renal failure, a history of cardiovascular or cerebrovascular disease were exclusion criteria. Subjects who were receiving lipid-lowering therapy, antihypertensive or anti-aggregant drugs, nitrates or long-term systemic steroids were also excluded. The mean IMT values of the right, left and averaged CCA of the psoriasis patients were significantly higher, compared with the controls (0.607 +/- 0.144 mm vs. 0.532 +/- 0.101 mm, 0.611 +/- 0.157 mm vs. 0.521 +/- 0.117 mm, and 0.609 +/- 0.146 mm vs. 0.526 +/- 0.104 mm; P = 0.006, P = 0.003 and P = 0.003, respectively). The mean FMD and NTD values of the psoriasis patients were significantly lower, compared with the controls (13.36 +/- 6.39 mm vs. 19.60 +/- 11.23 mm and 21.08 +/- 8.38 mm vs. 26.85 +/- 12.38 mm; P = 0.002 and P = 0.013, respectively). Multiple linear regression analysis revealed a significant association between psoriasis and the IMT, FMD and NTD. Moreover, the FMD in psoriasis patients was associated with disease duration. Psoriasis patients had impaired endothelial function and thicker IMT of the CCA, compared with the healthy control subjects. The presence of psoriasis was an independent risk factor for subclinical atherosclerosis.None declared.Öğe Myocardial perfusion is preserved in patients with psoriasis without clinically evident cardiovascular disease(Wiley, 2009) Yalcin, H.; Balci, D. D.; Ucar, E.; Ozcelik, N.; Tasci, C.; Seyfeli, E.; Akgul, F.Psoriasis is associated with a premature atherosclerosis due to the chronic inflammatory process. To evaluate the effect of disease process on myocardial perfusion, we planned to perform 99mTc-MIBI myocardial perfusion single photon emission computed tomography (SPECT) in patients with psoriasis. The study group consisted of 28 psoriasis patients (17 men, 11 women), aged 18-76 years, and mean age 41.2 +/- 14.1 years. The patients were selected among those who were older than 18 years and longer than 10 years of disease duration with more than two times of systemic treatment. All patients underwent 99mTc-MIBI myocardial perfusion SPECT with the same day protocol. We detected various risk factors including smoking habits in 7, family history of cardiovascular disease in 4, hypertension in 1, hyperlipidemia in 9 patients. We completed myocardial perfusion SPECT for each patient and found normal perfusion pattern in SPECT images. We detected that myocardial perfusion is preserved in the patients with psoriasis. The majority of acute heart attacks are caused by noncritical coronary stenosis and this may be an explanation for increased cardiovascular risk in these patients despite normal coronary perfusion.Öğe The Neuroprotective and Anti-inflammatory Effects of Diltiazem in Spinal Cord Ischaemia-Reperfusion Injury(Field House Publishing Llp, 2009) Fansa, I.; Altug, M. E.; Melek, I.; Ucar, E.; Kontas, T.; Akcora, B.; Atik, E.The protective effects of diltiazem were examined in a rabbit model of spinal cord ischaemia-reperfusion induced by infrarenal aortic occlusion for 30 min. In the diltiazem group (n = 6), an intravenous infusion (2 mu g/kg per min) was started 10 min before ischaemia induction; normal saline solution was infused in the control group (n = 6). Neurological function was assessed using modified Tarlov criteria 24 h after surgery. Plasma samples were analysed for interleukin (IL)-6 and IL-10. Spinal tissue was analysed for malondialdehyde, nitric oxide and reduced glutathione activities. Tarlov scores of the diltiazem-treated rabbits indicated significantly improved hind-limb motor function compared with the control group. The diltiazem group also had better quantitative and qualitative histopathological findings. Diltiazem infusion significantly reduced IL-6 levels 3 and 24 h after reperfusion compared with the control group. The mean IL-10 level in the diltiazem group was significantly higher than in the control group 24 h after reperfusion. It is concluded that diltiazem has cytoprotective and anti-inflammatory properties, leading to reduced spinal cord injury.Öğe RELATIONSHIP BETWEEN METABOLIC SYNDROME AND INFLAMMATION IN PERITONEAL DIALYSIS PATIENTS(Sage Publications Inc, 2012) Borazan, A.; Ucar, E.; Gursu, M.; Emir, I.; Ozturk, Y.We aimed to investigate the relationship between inflammation and metabolic syndrome as defined by the National Cholesterol Education Program Adults Treatment Panel III (NCEP-ATP III) diagnostic criteria in peritoneal dialysis patients. Ninety-four patients treated with peritoneal dialysis were included in the study. Patients' age, sex, weight, waist circumference, arterial blood pressure, fasting blood glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, C-reactive protein, albumin, uric acid and fibrinogen levels were recorded. Fourty-one patients diagnosed with metabolic syndrome and 53 peritoneal dialysis patients without metabolic syndrome were identified. In the metabolic syndrome group mean decrease in serum albumin and mean increase in C-reactive protein and fibrinogen was significantly different from the other group (p < 0.05, p < 0.05, p < 0.05, respectively). When gender, diabetes mellitus, and hypertension status were evaluated, the difference was not significant (p > 0.05). Peritoneal dialysis patients with metabolic syndrome should also be assessed for inflammation.Öğe The Relationship between Mortality and Inflammation in Patients with Gastrointestinal Bleeding(Sage Publications Ltd, 2009) Koseoglu, Z.; Ozkan, O. V.; Semerci, E.; Aslan, A.; Yetim, I.; Ucar, E.; Kuvandik, G.The objective of this study was to investigate the association between mortality and inflammation in patients who were admitted to the emergency room with gastrointestinal bleeding. Patients (n = 96) managed at two medical centres were included in the study. Initial levels of serum C-reactive protein (CRP), haemoglobin and albumin, and leucocyte and thrombocyte counts for 28 patients who died were compared with those for the 68 patients who survived and were successfully discharged. The data were analysed using the chi(2)-test. Serum levels of CRP and leucocyte counts were significantly higher, and albumin and haemoglobin were significantly lower in patients who died compared with patients who survived. The increased levels of serum CRP and leucocyte counts, and decreased levels of albumin and haemoglobin were found to be independent risk factors for mortality. It is concluded that increased serum CRP levels and leucocyte counts combined with decreased albumin and haemoglobin levels on admission to the emergency room may be used as predictive factors of mortality in patients with gastrointestinal bleeding.Öğe The use of the patient safety form in patients with inflammatory bowel disease, can improve the low screening and starting HBV prophylaxis rates in real life(Oxford Univ Press, 2019) Demir, M.; Ucar, E.; Celik, M. M.[Abstract Not Available]
