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    ANTI-INFLAMMATORY DRUG-LOADED BIOPOLYMERIC SPONGIOUS MATRICES WITH THERAPEUTIC PERSPECTIVES IN BURNS TREATMENT
    (Soc Stinte Farmaceutice Romania, 2018) Udeanu, Denisa Ioana; Kaya, Madalina Georgiana Albu; Ghica, Mihaela Violeta; Marin, Stefania; Marin, Maria Minodora; Kaya, Durmus Alpaslan; Popa, Lacramioara
    The most important goals of burns treatment suppose a fast skin regeneration to promote healing, the initial pain reduction and minimal scars forming. The development of new biopolymers-based wound dressings to ensure a proper healing process is nowadays a major challenge considering the incidence and consequences of burns. Our previously designed anti-inflammatory drug-loaded biopolymeric spongious matrices were initially tested by in vitro analysis and revealed proper morphological structure, swelling ability, degradation profiles and drug release patterns, indicating their potential use for burns treatment. Thus, the study aims to evaluate some collagen-sodium carboxymethylcellulose spongious matrices with or without mefenamic acid as non-steroidal anti-inflammatory drug in experimentally induced burns on Wistar rats, a frequently used animal model for the assessment of wounds healing. The treatment with the designed sponges promoted the wound healing compared to the classical treated control group. The sponges with mefenamic acid accelerated the healing process with a faster epithelial regeneration and a minimal scarring in comparison with the formulations containing no anti-inflammatory drug.
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    Polymer – flufenamic acid delivery systems for injured skin
    (2022) Marin, Maria Minodora; Ghıca, Mihaela Violeta; Kaya, Durmuş Alpaslan; Udeanu, Denisa Ioana; Kaya, Madalina Albu; Dinu-Pirvu, Cristina-Elena; Popa, Lacramıoara
    Collagen, the main protein of the body, is extracted in different forms and used as reservoir for drug delivery. The aim of this work was to obtain a drug delivery system based on collagen-dextran matrices cross-linked with glutaraldehyde as support and flufenamic acid and/or microcapsules with flufenamic acid as drug. The flufenamic acid was encapsulated in polymeric microcapsules consisting in gelatin, alginate, and sodium carboxymethyl cellulose. The morphology of matrices was determined by water absorption and contact angle. The biodegradation was performed in collagenase solution. In vitroflufenamic acid release profiles were built and the kinetic mechanism was set according to different mathematical models. The pharmacological studies followed the effect of collagen formulations treatment on the healing process of Wistar rats which were induced experimental wounds. The studied matrices proved that flufenamic acid delivery can be controlled, and the healing can be completed using the designed spongious matrices.