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    Can the ductus venosus doppler predict the hemoglobinopathies?
    (E-Century Publishing Corp, 2015) Karateke, Atilla; Silfeler, Dilek Benk; Gungoren, Arif; Kurt, Raziye Keskin; Okyay, Ayse Guler; Dokuyucu, Recep; Ulutas, Turker
    Objective: The aim of our study was to investigate the ductus venosus doppler between 11-13+6 (weekday) in pregnant women with hemoglobinopaties and its relation with fetal outcomes. Material and methods: A total of 100 pregnant women with hemoglobinopathies and 100 healthy pregnant women were included in our study. Ultrasonography (USG) was performed to all pregnant women and the ductus venosus doppler (DVD) flows were evaluated. The results were statistically analyzed. Results: The mean hemoglobin level was significantly lower in hemoglobinopathy group (9.7 +/- 0.7) than control group (10.67 +/- 0.82) (P<0.001). There was a significant relationship between Vmax, Vmin, S/D and reverse 'a' wave in fetuses with hemoglobinopathies. Vmax, Vmin and S/D parameters were higher in the group of hemoglobinopathies (respectively mean value, 31.3 +/- 1.66, 8.90 +/- 0.81, 2.97 +/- 0.49). Reverse 'a' wave was detected especially in all fetuses with sickle cell anemia. There was no significantly relationship between the groups in terms of PI, RI and HR. In a logistic regression analyses, fetal hemoglobinopathy was independently associated with Vmin (beta = 1.07, P = 0.001), S/D (beta = 2.61, P = 0.001) and reverse 'a' wave (beta = 2.46, P = 0.004). Conclusion: Pregnant women with hemoglobinopathies had changed ductus venosus doppler values in compared to normal pregnant women. Maternal anemia may cause this doppler changes. Furthermore all fetuses with sickle cell anemia (n = 5) had abnormal ductus venosus doppler findings. Further studies are needed to investigate the relationship between abnormal ductus venosus doppler findings and fetuses diagnosed with sickle cell anemia.
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    The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score
    (Elsevier Science Inc, 2013) Inci, Mehmet; Rifaioglu, Murat Mehmet; Inci, Melek; Celik, Murat; Demir, Mehmet; Ulutas, Turker; Davarci, Mursel
    OBJECTIVE To investigate the total prostate-specific antigen (tPSA), free PSA (fPSA), and free/total PSA (fPSA/tPSA) ratio in patients with liver cirrhosis (LC) according to the severity of hepatic insufficiency. METHODS Eighty-two male patients with LC were studied. The severity of liver disease was categorized by Child-Pugh score (Child-Pugh A, B, and C). Forty-two age-matched healthy subjects were used as a control group. The tPSA, fPSA, fPSA/tPSA ratio, total prostate volume (TPV), total testosterone (TT), and total protein (TP) were measured. The LC group was compared with the control group in terms of these parameters. In addition, intra-comparison and inter-comparison was made between all the Child-Pugh groups and normal subjects, in terms of these parameters. RESULTS The tPSA and fPSA levels in LC cases, Child-Pugh A, Child-Pugh B, and Child-Pugh C groups were significantly decreased compared with the control group. The ratio of fPSA/tPSA in the LC subjects and Child-Pugh A groups significantly increased compared with the control group. TT, TP levels, and TPV in patients with LC were significantly lower compared with the control group and the results were significantly correlated with the Child-Pugh score. CONCLUSION The present study reveals that tPSA and fPSA were decreased in patients with LC in comparison to healthy subjects in terms of 3 mechanisms. First, it might be due to shrunken prostatic volume. Second, it also resulted in decreased levels of testosterone because of the abnormality of hypothalamic-pituitary-testicular axis. Third, it might be the diminished serum protein level in the composition of the PSA. UROLOGY 81: 617-622, 2013. (c) 2013 Elsevier Inc.