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Öğe BISPHENOL A LEVELS IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND ITS CORRELATION WITH DISEASE ACTIVITY(Bmj Publishing Group, 2014) Ustun, N.; Ustun, I.; Yagiz, A. E.; Okur, R.; Turhanoqlu, A. D.; Sungur, S.; Gokce, C.[Abstract Not Available]Öğe Diffuse osteosclerosis in a patient with prostate cancer(Springer London Ltd, 2014) Ustun, N.; Ustun, I.; Ozgur, T.; Atci, N.; Aydogan, F.; Sumbul, A. T.; Turhanoglu, A. D.A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was -2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.Öğe EVALUATION OF ATHEROSCLEROTIC RISK FACTORS AND CAROTID INTIMA MEDIA THICKNESS IN HEALTHY OFFSPRING OF TYPE 2 DIABETIC PATIENTS(Editura Acad Romane, 2010) Ustun, I.; Aydin, Y.; Arduc, A. Ary; Berker, D.; Ozuguz, U.; Yulmaz, M.; Erden, G.Aim is to evaluate atherosclerotic risk factors and carotid intima media thickness [CIMT] in offspring of type 2 Diabetes Mellitus [DM] patients with normal glucose tolerance. Methods. We evaluated 96 offspring of Type 2 DM patients and 39 healthy control who were in similar age, sex and body mass. We measured fasting blood glucose [FBG], postprandial blood glucose [PBG], insulin, uric acid, homocystein, fibrinogen, HOMA-IR, lipid profile, hsCRP, microalbuminuria, glycosylated hemoglobin A1c and CIMT by Doppler ultrasonography. Results. FBG was found higher in study group [p<0.001]. The HOMA-IR was 1.7+/-0.98 and 1.2+/-0.58 mg/dL x uUI/mL for study and control group, respectively [p=0.007]. T-Cholesterol, triglycerides, HDL-C, LDL-C and homocystein levels were not different. HsCRP and fibrinogen levels were higher in study group [p=0.014 and p=0.035, respectively]. Microalbuminuria levels were higher in study group but not significant [p=0.111]. CIMT in study group increased distinctively [p<0,001]. In regression analysis, being in study group causes a significant increase on the mean CIMT level by 0.057 mm [0.029-0.086] Conclusion. Our study demonstrated that various atherosclerotic risk factors are aggregated in offspring of Type 2 DM patients having NUT even before they develop glucose intolerance. Having a diabetic family alone might be effective in developing increased CIMT.Öğe Evaluation of atherosclerotic risk factors and carotid intima media thickness in healthy offspring of type 2 diabetic patients(2010) Ustun, I.; Aydin, Y.; Arduç, A. Ar?; Berker, D.; Ozuguz, U.; Y?lmaz, M.; Erden, G.Aim is to evaluate atherosclerotic risk factors and carotid intima media thickness [CIMT] in offspring of type 2 Diabetes Mellitus [DM] patients with normal glucose tolerance. Methods. We evaluated 96 offspring of Type 2 DM patients and 39 healthy control who were in similar age, sex and body mass. We measured fasting blood glucose [FBG], postprandial blood glucose [PBG], insulin, uric acid, homocystein, fibrinogen, HOMA-IR, lipid profile, hsCRP, microalbuminuria, glycosylated hemoglobin A1c and CIMT by Doppler ultrasonography. Results. FBG was found higher in study group [p<0.001]. The HOMA-IR was 1.7±0.98 and 1.2±0.58 mg/dL x uUI/mL for study and control group, respectively [p=0.007]. TCholesterol, triglycerides, HDL-C, LDL-C and homocystein levels were not different. HsCRP and fibrinogen levels were higher in study group [p=0.014 and p=0.035, respectively]. Microalbuminuria levels were higher in study group but not significant [p=0.111]. CIMT in study group increased distinctively [p<0,001]. In regression analysis, being in study group causes a significant increase on the mean CIMT level by 0.057 mm [0.029-0.086] Conclusion. Our study demonstrated that various atherosclerotic risk factors are aggregated in offspring of Type 2 DM patients having NGT even before they develop glucose intolerance. Having a diabetic family alone might be effective in developing increased CIMT.Öğe Investigation of Bisphenol A as an endocrine disruptor, total thiol, malondialdehyde, and C-reactive protein levels in chronic obstructive pulmonary disease(Verduci Publisher, 2014) Erden, E. S.; Motor, S.; Ustun, I.; Demirkose, M.; Yuksel, R.; Okur, R.; Oktar, S.OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a common health problem and it is associated with oxidant/antioxidant imbalance and systemic inflammation. Bisphenol A (BPA) is an endocrine disruptor agent, exerting a wide variety of metabolic effects. Also, BPA is related with oxidative stress, decreased antioxidant enzymes, and inflammation. The aim of this study is to investigate the relationships between COPD and serum BPA, Creactive protein (CRP), malondialdehyde (MDA), and total thiol levels. PATIENTS AND METHODS: This study was enrolled at 83 subjects that they were divided into two groups: control (n = 33), COPD (n = 50). The serum BPA, CRP, MDA, and total thiol levels were analyzed. RESULTS: The CRP and BPA levels were significantly higher in the COPD patients than control subjects. The total thiol levels were significantly lower in COPD cases than the controls. There is no different between groups for MDA. Also, there had a linear relationship between BPA and CRP in correlation analysis. CONCLUSIONS: COPD is associated with high serum BPA, CRP and low total thiol levels in comparison with healthy individuals. It is suggested that BPA might have a role in the etiopathogenesis of COPD.Öğe Lung tuberculosis causing false positivity on positron emission tomography(2013) Muallaoglu, Sadik; Ustun, I.; Kaya, Y.; Leblebici, I.[No abstract available]