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Öğe ASSESSMENT OF LEFT VENTRICULAR DYSSYNCHRONY IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER(Bmj Publishing Group, 2014) Ustun, N.; Celik, M.; Kurt, M.; Sen, N.; Akcay, A. B.; Turhanoglu, A. D.[Abstract Not Available]Öğe Association with isokinetic ankle strength measurements and normal clinical muscle testing in sciatica patients(Ios Press, 2013) Ustun, N.; Erol, O.; Ozcakar, L.; Ceceli, E.; Ciner, O. Akar; Yorgancioglu, Z. R.BACKGROUND: Sensitive muscle strength tests are needed to measure muscle strength in the diagnosis and management of sciatica patients. OBJECTIVE: The aim of this study was to assess the isokinetic muscle strength in sciatica patients' and control subjects' ankles that exhibited normal ankle muscle strength when measured clinically. METHODS: Forty-six patients with L5 and/or S1 nerve compression, and whose age, sex, weight, and height matched 36 healthy volunteers, were recruited to the study. Heel-walking, toe-walking, and manual muscle testing were used to perform ankle dorsiflexion and plantar flexion strengths in clinical examination. Patients with normal ankle dorsiflexion and plantar flexion strengths assessed by manual muscle testing and heel-and toe-walking tests were included in the study. Bilateral isokinetic (concentric/concentric) ankle plantar-flexion-dorsiflexion measurements of the patients and controls were performed within the protocol of 30 degrees /sec (5 repetitions). Peak torque and peak torque/body weight were obtained for each ankle motion of the involved limb at 30 degrees /s speed. RESULTS: L5 and/or S1 nerve compression was evident in 46 patients (76 injured limbs). Mean disease duration was two years. The plantar flexion muscle strength of the patients was found to be lower than that of the controls (p = 0.036). The dorsiflexion muscle strength of the patients was found to be the same as that of the controls (p = 0.211). CONCLUSIONS: Isokinetic testing is superior to clinical muscle testing when evaluating ankle plantar flexion torque in sciatica patients. Therefore, isokinetic muscle testing may be helpful when deciding whether to place a patient into a focused rehabilitation program.Öğe BISPHENOL A LEVELS IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND ITS CORRELATION WITH DISEASE ACTIVITY(Bmj Publishing Group, 2014) Ustun, N.; Ustun, I.; Yagiz, A. E.; Okur, R.; Turhanoqlu, A. D.; Sungur, S.; Gokce, C.[Abstract Not Available]Öğe Diffuse osteosclerosis in a patient with prostate cancer(Springer London Ltd, 2014) Ustun, N.; Ustun, I.; Ozgur, T.; Atci, N.; Aydogan, F.; Sumbul, A. T.; Turhanoglu, A. D.A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was -2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.Öğe Effects of habitual knuckle cracking on metacarpal cartilage thickness and grip strength(Elsevier, 2017) Yildizgoren, M. T.; Ekiz, T.; Nizamogullari, S.; Turhanoglu, A. D.; Guler, H.; Ustun, N.; Kara, M.Joint cracking involves a manipulation of the finger joints resulting in an audible crack. This study aimed to determine whether habitual knuckle cracking (KC) leads to an alteration in grip strength and metacarpal head (MH) cartilage thickness. Thirty-five habitual knuckle crackers (cracking their joints >= 5 times/day) (20 M, 15 F, aged 19-27 years) and 35 age-, gender-, and body mass index-matched non-crackers were enrolled in the study. MH cartilage thickness was measured with ultrasound and grip strength was measured with an analog Jamar hand dynamometer. Grip strength was similar between groups (P > 0.05). Habitual knuckle crackers had thicker MH cartilage in the dominant and non-dominant hands than those of the controls (P = 0.038 and P = 0.005, respectively). There was no correlation between MH cartilage thickness and grip strength in both groups (P > 0.05). While habitual KC does not affect handgrip strength, it appears to be associated with increased MH cartilage thickness. (C) 2016 SFCM. Published by Elsevier Masson SAS. All rights reserved.Öğe PRECLINICAL ATHEROSCLEROSIS IN PATIENTS WITH ANKYLOSING SPONDYLITIS WITHOUT CLINICALLY EVIDENT CARDIOVASCULAR DISEASE(Bmj Publishing Group, 2014) Turhanoglu, A. D.; Ustun, N.; Kurt, M.; Yagiz, A. E.; Guler, H.[Abstract Not Available]Öğe Sclerostin and Dkk-1 in patients with ankylosing spondylitis(Publisaude-Edicoes Medicas Lda, 2014) Ustun, N.; Tok, F.; Kalyoncu, U.; Motor, S.; Yuksel, R.; Yagiz, A. E.; Guler, H.Objective: To determine the serum Dickkopf-related protein 1 (Dkk-1) and sclerostin levels, and their relationship to structural damage and disease activity in patients with ankylosing spondylitis (AS), as well as to compare the serum Dldc-1 and sclerostin levels in patients receiving and not receiving anti-TNF-alpha treatment. Materials and Methods: This cross-sectional study included 44 AS patients and 41 healthy age- and gender-matched controls. Demographic data, disease activity parameters, and Bath AnIcylosing Spondylitis Radiologic Index (BASRI) scores were recorded. Serum Dkk-1 and sclerostin levels were measured using commercially available ELISA. Results: Serum Dkk-1 levels were lower (P > 0.05) and sclerostin levels were significantly lower (P < 0.05) in the AS patients than in the controls. Dkk-1 and sclerostin levels were similar in the patients that did and didn't receive anti-TNF-alpha treatment, and in the patients with active and inactive disease (P > 0.05). There wasn't a correlation between serum Dkk-1 or sclerostin levels, and disease activity indices (P > 0.05). BASRI scores did not correlate with serum Dkk-1 or sclerostin levels (P > 0.05). Discussion: Sclerostin expression is impaired in AS, but this is not the case for Dkk-1. The lack of an association between Dkk-1 or sclerostin levels, and anti-TNF-alpha treatment, disease activity indices, and radiological damage might indicate that neither the Dkk-1 nor sclerostin level induce inflammation and radiological damage in AS patients. Pathologic bone formation in AS might be due to molecular dysfunction of sclerostin and Dkk-1 at the cellular level.Öğe SUBCLINICAL LEFT VENTRICULAR DYSFUNCTION IN PATIENTS WITH ANKYLOSING SPONDYLITIS WITHOUT CLINICALLY EVIDENT CARDIOVASCULAR DISEASE: A TWO-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHIC STUDY(Bmj Publishing Group, 2014) Ustun, N.; Kurt, M.; Yagiz, A. E.; Guler, H.; Turhanoglu, A. D.[Abstract Not Available]
