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    Antimicrobial properties of bioactive compounds isolated from epidermal mucus in two Ray species (Dasyatis marmorata and Gymnura altavela)
    (Pharmacotherapy Group, 2020) Uyan, Ali; Turan, Cemal; Erdogan-Eliuz, Elif Ayse; Sangun, Mustafa Kemal
    Purpose: To investigate the occurrence and antimicrobial effects of certain biochemical compounds in the epidermal mucus secretions of fish and to demonstrate their potential for biomedical applications. Methods: Crude, aqueous, and acidic epidermal mucus samples were collected from live ray specimens. Gas chromatography and gas chromatography-mass spectrometry (GC/MS) analyses were performed to identify the biochemical compounds present in the mucus. The spectrophotometric broth microdllution method was used to determine the antibacterial and antifungal properties of the mucus extracts. The bacterial strains, Bacillus subtilis, Escherichia coli, Enterococcus faecalis, and Klebsiella pneumonia, were used for the tests, as well as the fungal strains, Candida parapsilosis and Candida albicans. Results: GC/MS analysis revealed the presence of several hydrocarbon-derived compounds in the epidermal mucus of the two ray species. The acidic extract of G. altavela epidermal mucus produced a high MIC value, indicating the highest inhibitory effect of 8.64 mu L against E. coli, while the crude extract of G. altavela epidermal mucus (41.13 mu L against B. subtilis) was the least effective. Conclusion: Epidermal mucus extracts, especially when acid-based, displays strong antimicrobial properties against all the tested pathogens. These findings suggest the plants possess some potential for the development of novel antimicrobial components for applications in medicine.
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    Biochemical compounds and their antimicrobial activities in epidermal mucus obtained from two ray species Dasyatis pastinaca and Raja miraletus
    (Cahiers De Biologie Marine, 2021) Uyan, Ali; Turan, Cemal; Erdogan, Elif Ayse; Sangun, Mustafa Kemal
    The epidermal mucus of two ray species Dasyatis pastinaca and Raja miraletus was analyzed to identify biochemical compounds and explore their antimicrobial activities in order to point out their potential for human health-related applications. Epidermal mucus samples were extracted as acidic, crude and aqueous. Gas chromatography and gas chromatography-mass spectrometry (GC/MS) analyses were performed to determine the biochemical compounds of the mucus. The antibacterial and antifungal activities of the extracts obtained from mucus were analysed using the spectrophotometric broth microdilution method against bacterial (Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis and Enterococcus faecalis) and fungal (Candida albicans and Candida parapsilosis) strains. Gas chromatography and gas chromatography-mass spectrometry (GC/MS) analyses revealed the existence of several hydrocarbon-derived compounds and polycyclic aromatic hydrocarbons. In terms of antimicrobial activity, the highest detected MIC (minimum inhibitory concentration) value was 9.78 mu L for the acidic extract of R. miraletus epidermal mucus (RmAC) against E. faecalis, while the lowest MIC value was 80.88 mu L for the acidic extract of R. miraletus epidermal mucus (RmAC) against E. coli. The extracts of epidermal mucus from D. pastinaca and R. miraletus showed antimicrobial activities against all the used pathogens with varying degrees of efficiency and thus may be evaluated as a potential source of marine-derived antimicrobial components for biomedical purposes. gazeuse et chromatographie en phase gazeuse-spectrometrie de masse (GC/MS) ont revele l'existence de plusieurs composes derives d'hydrocarbures et d'hydrocarbures aromatiques polycycliques. Pour l'analyse antimicrobienne, la valeur MIC (minimum inhibitory concentration) la plus elevee detectee etait de 9,78 mu L pour l'extrait acide de mucus epidermique de R. miraletus (RmAC) contre E. faecalis, tandis que la valeur MIC la plus basse etait de 80,88 mu L pour l'extrait acide de mucus epidermique de R. miraletus (RmAC) contre E. coli. Les extraits de mucus epidermique de D. pastinaca et R. miraletus ont neanmoins montre des activites antimicrobiennes contre tous les agents pathogenes utilises avec divers degres d'efficacite et peuvent donc etre consideres comme une source potentielle de composants antimicrobiens d'origine marine a des fins biomedicales.
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    Classification of Fish Species With Two Dorsal Fins Using Centroid-Contour Distance
    (Ieee, 2015) Iscimen, Bilal; Kutlu, Yakup; Uyan, Ali; Turan, Cemal
    Color, texture and shape are generally used features in order to recognise an object from an image. In this study centroid-contour distance method is used in order to classify fish species with two dorsal fins. Therefore, fish images with two dorsal fins were used from fish images database taken under specific conditions. Various image processing methods were applied on images in order to extract centroid-contour distances. These distances were used as features and Nearest Neighbour algorithm was used for classification. 15 species from 427 fish images were classified with 95% general accuracy achievement.
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    FIRST RECORD OF MARBLED STINGRAY, DASYATIS MARMORATA (ELASMOBRANCHII: MYLIOBATIFORMES: DASYATIDAE), ON THE COAST OF TURKEY, NORTH-EASTERN MEDITERRANEAN
    (Wydawnictwo Akad Rolniczej W Szczecinie, 2014) Erguden, Deniz; Turan, Cemal; Gurlek, Mevlut; Uyan, Ali; Reyhaniye, Asil Nadir
    Two specimens of marbled stingray, Dasyatis marmorata (Steindachner, 1892), were captured for the first time on 24-25 October 2013 in the Iskenderun Bay, located in the north-eastern Mediterranean coast of Turkey. This is the first record of D. marmorata in Turkish coastal waters and the seventh dasyatid species reported to date from the area.
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    FIRST RECORD OF THE INDIAN OCEAN TWOSPOT CARDINALFISH, CHEILODIPTERUS NOVEMSTRIATUS (ACTINOPTERYGII: PERCIFORMES: APOGONIDAE), FROM TURKISH MARINE WATERS
    (Pensoft Publishers, 2015) Turan, Cemal; Erguden, Deniz; Uygur, Necdet; Gurlek, Mevlut; Erdogan, Zeliha A.; Sonmez, Bektas; Uyan, Ali
    Indian Ocean twospot cardinalfish, Cheilodipterus novemstriatus (Ruppell, 1838), is recorded for the first time from the Turkish marine waters. Two specimens of C. novemstriatus were sampled with a purse seiner on 1 December 2014, and also a school of C. novemstriatus was photographed during scuba diving at a depth of 13 m on a rocky surface on 8 December 2014 in the Cevlik coast, Iskenderun Bay, north-eastern Mediterranean of Turkey. With the present report, the number of alien cardinal fish species reported in the Turkish coasts has reached five.
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    Kırlangıç (Chelidonichthys lucerna Linnaeus, 1758) populasyonlarının genetik ve morfolojik yapı analizi
    (Hatay Mustafa Kemal Üniversitesi, 2014) Uyan, Ali; Turan, Cemal
    Chelidonichthys lucerna Karadeniz, Marmara, Ege ve Akdeniz'de en bol bulunan ve Triglidae türleri içerisinde ticari açıdan en önemli türdür. Bu çalışmada, C. lucerna populasyonlarının genetik ve morfolojik olarak incelenmesi amaçlanmıştır. Morfolojik analiz için morfometrik ve meristik karakterler kullanılmış ve dizin analizi için ise mtDNA 16S rRNA geni kullanılmıştır. Dizi analizi sonucunda elde edilen 16S rRNA geninin ortalama nükleotid kompozisyonu T = % 21.5, C = % 26.6, A = % 31.4 ve G = % 20.5 olarak belirlenmiştir. 809 bç'lik bölgesi çalışılan 16S rRNA geninin 796 bç'lik kısmı evrimsel süreçten etkilenmemiş bölgelerden oluşurken 13 bç'lik kısmı ise populasyonlar arasında çeşitli sebeplerden ötürü değişen bölge olarak tespit edilmiştir. 6 bç'lik bölge ise populasyonlar arasında parsimoni anlamlı bölge görevi görmüştür. Populasyonlar içi ortalama genetik farklılık değeri ise 0.0016 olarak bulunmuştur. En düşük genetik çeşitlilik İskenderun populasyonunda, en yüksek genetik çeşitlilik ise Marmara populasyonunda gözlenmiştir. Tüm populasyonlardan toplam 14 adet haplotip elde edilmiştir. En yüksek haplotip çeşitliliği Marmara populasyonunda, en düşük haplotip çeşitliliği ise İskenderun populasyonunda görülmüştür. Populasyonlar arası ortalama haploid çeşitliliği de 0.7558 bulunmuştur. Populasyonlar arası genetik farklılıklara bakıldığında, Akçakoca ile Marmara populasyonları en az farklılaşma düzeyini göstermiştir (0.0012). En yüksek genetik farklılaşma düzeyi Antalya ile İzmir ve İskenderun ile İzmir populasyonları arasında bulunmuştur (0.0021). Komşu katılımlı soyağacına (Neighbour Joining tree) göre Antalya ve İskenderun populasyonları birbirlerine yakın populasyonlar olarak bulunmuştur. İzmir populasyonu ise diğer populasyonlardan oldukça uzak çıkmıştır. Morfolojik karakterlerin kümelerarası korelasyon analizinde Akçakoca populasyonunun diğer populasyonlardan tamamıyla farklı olduğu gözlenmiştir. Ancak diğer populasyonların birbirlerinden istatistiksel anlamda önemli derecede farklı olmadığı gözlenmiştir. Morfolojik yakınlık matrisine göre Akçakoca ile Antalya populasyonları birbirine en uzak populasyonlar olmuştur. İzmir ile İskenderun populasyonları ise morfolojik olarak birbirlerine en yakın populasyonlar olmuştur. UPGM soyağacına göre İzmir populasyonu ile İskenderun populasyonu birbirine yakın ilişkilendirilmiş, Akçakoca populasyonu ise diğer populasyonlardan tamamen ayrı gruplandırılmıştır.