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Öğe Assessment of the relationship between coronary artery ectasia and erectile function score(Nature Publishing Group, 2011) Akcay, A. B.; Inci, M.; Bilen, P.; Acele, A.; Sen, N.; Yalcin, F.The relation between coronary artery ectasia (CAE) and erectile dysfunction (ED) has not been studied so far. Hence, we decided to investigate the erectile function score in patients with CAE. We investigated the international index of erectile function (IIEF)-5 score in 34 men with CAE, 38 men with coronary artery disease (CAD), and 30 male controls with normal coronary arteries whose mean ages were 53.2 +/- 5.6, 51.4 +/- 7.8, and 49.6 +/- 8.6 years, respectively. Erectile function was evaluated by the five-item version of the IIEF-5. Each question is scored from 0 to 5. CAE was defined as being without any stenotic lesions with a visual assessment of the coronary arteries showing a luminal dilatation 1.5-fold or more of the adjacent normal coronary segments. IIEF-5 scores in CAE group were found statistically significantly lower than the control group (P < 0.001). There were no statistically significant differences in IIEF-5 scores between CAE and CAD groups (P = 0.13). We have shown for the first time that patients with CAE have lower IIEF-5 scores compared with controls with normal coronary angiograms. Many studies reported that endothelial dysfunction in patients with CAE was more dominant than those with CAD. This study suggests that ED and CAE may be different manifestations of a common underlying vascular pathology and vasculogenic ED is frequently seen in CAE at least as much as in CAD. International Journal of Impotence Research (2011) 23, 128-133; doi:10.1038/ijir.2011.10; published online 28 April 2011Öğe ASSESSMENT OF THE RELATIONSHIP BETWEEN CORONARY ARTERY ECTASIA AND ERECTILE FUNCTION SCORE(Elsevier Ireland Ltd, 2011) Akcay, A. B.; Sen, N.; Inci, M.; Bilen, P.; Yeral, N.; Acele, A.; Yalcin, F.[Abstract Not Available]Öğe Association of left ventricular diastolic function abnormalities with aortic elastic properties in asymptomatic patients with type 2 diabetes mellitus. A tissue doppler echocardiographic study(Wiley, 2008) Seyfeli, E.; Duru, M.; Saglam, H.; Akgul, F.; Kuvandik, G.; Kaya, H.; Yalcin, F.Background: The aim of this study was to investigate the association between the aortic elastic properties and the left ventricular diastolic function measured by tissue Doppler echocardiography (TDE) in asymptomatic type 2 diabetes mellitus. Methods: Fifty-seven asymptomatic patients with type 2 diabetes (33 women, mean age: 49 +/- 6 years) and 25 healthy control subjects (19 women, mean age: 46 +/- 7 years) were included in the present study. Diastolic filling indices were measured by conventional (CE) and tissue Doppler echocardiography. The aortic elastic properties [Aortic stiffness index (ASI), aortic distensibility and strain] were measured as previous definition. Results: Compared with control subjects, the ratio of LV diastolic abnormalities measured by CE and TDE were found higher in patients with type 2 diabetes (36% and 73.6%, p = 0.001, respectively, and 52% and 89.4%, p < 0.001, for septal annulus; 48% and 89.4%, p < 0.001 for septal basal respectively). The ASI was significantly higher (p < 0.001), aortic distensibility and aortic strain were also significantly lower in patients with type 2 diabetes than control subjects (p < 0.001 and p < 0.001 respectively). In the regression analysis, Ao distensibility was correlated to age (beta = -0.299, p = 0.004), septal basal Em/Am ratio (beta =0.543, p < 0.001) and HDL-cholesterol (beta = 0.192, p = 0.039). ASI was also correlated only to age (beta = 0.255, p = 0.044), the presence of diabetes mellitus (beta = 0.304, p = 0.009), mitral A wave (beta = 0.322, p = 0.013) and mitral annulus Em wave (beta = -0.505, p < 0.001). Conclusion: The aortic elastic function is impaired in asymptomatic patients with type 2 diabetes. Increased ASI and decreased Ao distensibility are closely associated with diastolic filling indices measured by CE and TDE.Öğe Can neurological soft signs be used to identify patients at risk of stroke in sickle cell disease?(Blackwell Publishing, 2006) Melek, I.; Duman, T.; Akgul, F.; Yalcin, F.[Abstract Not Available]Öğe Contractility evaluation by 2 dimensional echocardiography and gated SPECT myocardial perfusion scintigraphy in hypertensive patients with clinical presentation of atypical chest pain(Lithographia, 2011) Yalcin, H.; Karayalcin, B.; Boz, A.; Talay, B.; Belgi, A.; Yalcin, F.Background: Hypertension (HT) is a growing health problem in the population and associated with increased cardiovascular event risk and mortality. In hypertensive patients, progressive left ventricular (LV) contractility deterioration is detectable by gated single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy(9). We planned this study to explore the agreement in ejection fraction (EF) determination between 2 dimensional echocardiography and gated SPECT analysis in selected group of patients with hypertension. Patients and Methods: We studied 26 consecutive patients (mean age 56.5 +/- 8.8 years; 6 men) with hypertension. Quantitative contractility analysis by both echocardiography and SPECT at rest was performed to investigate the agreement between two diagnostic tests. Results: EF at rest was greater than 55 % in all patients. All patients had a clinical presentation of atypical chest pain. Therefore, in addition to quantitative contractility analysis at rest by echocardiography and myocardial SPECT perfusion scintigraphy, we examined ischemia by stress induction and determined that 10 patients had ischemic finding (38.4 %). The mean value of EF calculated by echocardiography was 67.5 +/- 5.7 %, while EF by gated SPECT was 72.8 +/- 8.5 %. We documented an acceptable agreement in EF determination between these 2 diagnostic tests by meaningful correlation (r = 0.556, p = 0.003). There was no regional contractility deterioration despite existence of ischemia in 10 patients of the study group. Conclusions: We observed that both echocardiography and gated SPECT can be used for quantification of EF in the hypertensive patients with an acceptable agreement. Hippokratia 2011; 15 (1): 64-68Öğe Doppler tissue imaging of the left and right ventricular function in multiple sclerosis(Blackwell Publishing, 2006) Melek, I.; Duman, T.; Akgul, F.; Seyfeli, E.; Yalcin, F.[Abstract Not Available]Öğe Effect of dobutamine stress on basal septal tissue dynamics in hypertensive patients with basal septal hypertrophy(Nature Publishing Group, 2006) Yalcin, F.; Yigit, F.; Erol, T.; Baltali, M.; Korkmaz, M. E.; Muederrisoglu, H.Left ventricular outflow tract (LVOT) obstruction has been classically observed in hypertrophic cardiomyopathy in which the LVOT obstruction is associated with asymmetric septal hypertrophy producing a systolic pressure gradient across the LVOT.(1) Basal septal hypertrophy (BSH) with hypertension may result in dynamic LVOT obstruction as well.(2,3) It was suggested that regional hypertrophy may be related to enhanced ventricular dynamics.(4)Öğe Effect of obesity on P-wave dispersion and QT dispersion in women(Nature Publishing Group, 2006) Seyfeli, E.; Duru, M.; Kuvandik, G.; Kaya, H.; Yalcin, F.Objective: The aim of this study was to investigate the effect of obesity on dispersion of P-wave duration and QTc interval in obese women. Methods: Forty-two obese women (Body mass index (BMI) 4073 kg/m(2), mean age 4579 years) and compared age-matched (BMI 2271 kg/m(2), mean age 41 +/- 6 years) twenty-five non-obese women were included in our study. Maximum and minimum P-wave duration, P-wave dispersion (difference between the maximum and the minimum P-wave duration), maximum and minimum QTc interval, and QTc dispersion (the difference between the maximum and the minimum QTc interval) were measured from 12-lead ECG. ECG's were transferred to a personal computer via a scanner and then used for magnification of 400 times by Adobe Photoshop software. Results: There was significant difference in BMI (40 +/- 3 vs 22 +/- 1 kg/m(2), P < 0.001, respectively) between obese and non-obese women. Obese women had higher Max. P-wave duration (116711 vs 94714 ms, P < 0.001), P-wave dispersion (51715 vs 26711 ms, P < 0.001), Max. QTc interval (449738 vs 419730 ms, P < 0.001) and QTc dispersion ( 57723 vs 38715 ms, P < 0.001) compared to non-obese women. A significant correlation was found between BMI and Max. P-wave duration (r = 0.584, P < 0.001), P-wave dispersion (r = 0.621, P < 0.001), Max. QTc interval (r = 0.410, P < 0.001), and QTc dispersion (r = 0.429, P < 0.001). In the linear regression analysis, compared to co-morbidity factors such as age, hypertension, diabetes mellitus and smoking, there was significant association between only BMI and electrocardiographic values (P-wave and QTc dispersion). Conclusion: We concluded that obesity caused significant increase in P-wave and QTc dispersion. Therefore, obese women may not only be under the risk of ventricular arrhythmias, but also they may under the risk of atrial arrhythmias.Öğe Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis(Wiley, 2009) Balci, D. D.; Balci, A.; Karazincir, S.; Ucar, E.; Iyigun, U.; Yalcin, F.; Seyfeli, E.Psoriasis is associated with an increased risk of atherosclerosis. This study compared subclinical atherosclerosis of the carotid and brachial arteries in psoriasis vulgaris patients and healthy controls using high-resolution ultrasonography. We studied 43 psoriasis patients and 43 healthy controls matched for age and sex. Flow-mediated dilatation (FMD) and nitroglycerin-induced dilatation (NTD) of the brachial artery and intima-media thickness (IMT) of the common carotid arteries (CCA) were measured ultrasonographically. Diabetes mellitus, hypertension, renal failure, a history of cardiovascular or cerebrovascular disease were exclusion criteria. Subjects who were receiving lipid-lowering therapy, antihypertensive or anti-aggregant drugs, nitrates or long-term systemic steroids were also excluded. The mean IMT values of the right, left and averaged CCA of the psoriasis patients were significantly higher, compared with the controls (0.607 +/- 0.144 mm vs. 0.532 +/- 0.101 mm, 0.611 +/- 0.157 mm vs. 0.521 +/- 0.117 mm, and 0.609 +/- 0.146 mm vs. 0.526 +/- 0.104 mm; P = 0.006, P = 0.003 and P = 0.003, respectively). The mean FMD and NTD values of the psoriasis patients were significantly lower, compared with the controls (13.36 +/- 6.39 mm vs. 19.60 +/- 11.23 mm and 21.08 +/- 8.38 mm vs. 26.85 +/- 12.38 mm; P = 0.002 and P = 0.013, respectively). Multiple linear regression analysis revealed a significant association between psoriasis and the IMT, FMD and NTD. Moreover, the FMD in psoriasis patients was associated with disease duration. Psoriasis patients had impaired endothelial function and thicker IMT of the CCA, compared with the healthy control subjects. The presence of psoriasis was an independent risk factor for subclinical atherosclerosis.None declared.Öğe Is androgenetic alopecia a risk for atherosclerosis?(Wiley, 2009) Dogramaci, A. C.; Balci, D. D.; Balci, A.; Karazincir, S.; Savas, N.; Topaloglu, C.; Yalcin, F.Several studies have demonstrated the presence of an association between androgenetic alopecia (AGA) and cardiovascular disease. The aim of this study was to evaluate subclinical atherosclerosis in patients with AGA and healthy controls by the incorporation of carotid intima-media thickness (IMT) and high-sensitive C-reactive protein (hs-CRP) along with echocardiography (ECHO) and exercise electrocardiography (ExECG). We performed a case-control study in 50 male patients with AGA and 31 age-matched healthy male controls with normal hair status. Both the AGA patients and controls with a history of diabetes mellitus, cigarette smoking, hypertension, cardiovascular or cerebrovascular disease, and renal failure were excluded. AGA was classified according to the Hamilton-Norwood scale. Serum lipids, serum hs-CRP, total testosterone, and dehydroepiandrosterone sulphate were examined in all study subjects. Carotid ultrasonography was used to measure the IMT of the common carotid arteries (CCA). ECHO and ExECG were performed in all subjects. IMT of the CCA was found to be significantly higher in patients with severe vertex pattern AGA when compared to patients with other patterns of AGA and healthy controls (P < 0.05). Hs-CRP in patients with any group of AGA was not significantly different from those healthy controls (P > 0.05). ECHO showed that cardiac structural and functional measures were in normal ranges. ExECG was also normal in all subjects. Severe vertex pattern AGA should be considered to have an increased risk of subclinical atherosclerosis. For this reason, CCA IMT measurement can be recommended as a non-invasive and early diagnostic method. None declared.Öğe Left ventricular wall function abnormalities in patients with ankylosing spondylitis evaluated by gated myocardial perfusion scintigraphy(Elsevier Science Inc, 2011) Yalcin, H.; Guler, H.; Gunay, E.; Yeral, N.; Turhanoglu, A.; Bolac, E.; Yalcin, F.Background: Ankylosing spondilitis (AS) is a chronic inflammatory disease with prominent inflammation in joints and extraarticular organs. AS patients have approximately two times more risk of mortality than the normal population. One reason for this increase in mortality is increased cardiovascular risk. In this study, we have aimed to evaluate myocardial perfusion and left ventricular function using Tc-99m-MIBI gated myocardial perfusion single photon emission computed tomography (SPECT). Material and methods: The study group consisted of 28 AS patients (19 men, 9 women), and mean age 39.46 +/- 10.98 years. All patients underwent Tc-99m-MIBI gated myocardial perfusion SPECT with the same day protocol. Results: We detected various risk factors including smoking habits in 12, family history of cardiovascular disease in 12, hypertension in 3, hyperlipidemia in 9 patients. We performed a myocardial perfusion SPECT for each patient and found normal perfusion pattern in SPECT images. Out of 28 patients, eight patients had normal perfusion but wall motion abnormalities. Conclusion: We detected that myocardial perfusion is preserved in the patients with AS. However, left ventricular wall motion abnormalities are seen. We concluded that ankylosing spondylitis may be associated with microvascular dysfunction and gated myocardial perfusion scintigraphy could be valuable in AS patients for the evaluation of LV function even if the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score are low and the disease duration shorter. (C) 2010 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe THE PREVALENCE OF LV DYSFUNCTION BASED ON ISCHEMIC BURDEN IN SOUTHERN TURKEY(Elsevier Ireland Ltd, 2011) Yalcin, F.; Ofgeli, M.; Yeral, N.; Akcay, A. B.; Bilen, P.; Gungor, M.; Kesici, T. T.[Abstract Not Available]Öğe REGIONAL LEFT VENTRICULAR PERFORMANCE IN HYPERTENSIVE PATIENTS WITH/WITHOUT LEFT VENTRICULAR HYPERTROPHY (LVH)(Lippincott Williams & Wilkins, 2009) Yalcin, F.; Topaloglu, C.; Seyfeli, E.; Akgul, F.[Abstract Not Available]Öğe The results of inspiratory muscle training on cardiac, respiratory, musculoskeletal, and psychological status in patients with stable angina: a randomized controlled trial(Taylor & Francis Ltd, 2023) Huzmeli, I; Ozer, A. Y.; Akkus, O.; Yalcin, F.Purpose To determine the effect of inspiratory muscle training (IMT) on respiratory and peripheral muscle strength, functional exercise capacity, health-related quality of life (HRQoL), fatigue, depression, and cardiac functions in patients with stable angina. Methods A randomized, controlled, single-blinded study. Twenty patients (59.95 +/- 7.35 y, LVEF = 58.77 +/- 7.49) with stable angina received IMT at the lowest load (10 cmH(2)O), and 20 patients (55.85 +/- 7.60 y, LVEF = 62.26 +/- 7.75) received training at 30% of maximal inspiratory pressure (MIP) seven days/8 weeks. Respiratory muscle strength (MIP; maximal expiratory pressure, MEP), peripheral muscle strength, pulmonary functions, functional exercise capacity (6-min walking test; exercise test), fatigue, HRQoL, depression, and cardiac functions were evaluated before and after. Results A statistical difference was found between groups in terms of respiratory and peripheral muscle strength, pulmonary functions, functional exercise capacity (p < 0.05). The results of fatigue, depression, HRQoL, and cardiac functions were similar between the groups (p > 0.05). Conclusions This study is the first to demonstrate the positive effects of IMT in patients with stable angina. IMT is a safe and effective method and is recommended to be added to cardiopulmonary rehabilitation programs and guidelines, as it results in increased peripheral muscle strength and functional exercise capacity in stable angina patients.
