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Öğe AMACR and iNOS expressions in prostate adenocarcinomas(Springer, 2012) Ozgur, T.; Atik, E.; Hakverdi, S.; Yaldiz, M.[Abstract Not Available]Öğe The Effects of Interferon ?2b on Chemically-induced Peritoneal Fibrosis and on Peritoneal Tissue MMP-2 and TIMP-2 Levels in Rats(Field House Publishing Llp, 2010) Ucar, E.; Borazan, A.; Semerci, E.; Binici, D. N.; Yaldiz, M.; Aysal, A.; Altug, E.This study investigated the effect of interferon alpha 2b on chlorhexidine gluconate (CH)-induced peritoneal fibrosis (PF) in rats and assessed peritoneal tissue levels of metalloproteinase (MMP)-2 and tissue inhibitors of metalloproteinases (TIMP)-2. Wistar albino rats (n = 8 per group) were treated as follows: control group, 3 ml/day of 0.9% saline intraperitoneally for 28 days; CH group, 0.1% CH (200 g [3 ml]/day) in 15% ethanol and 0.9% saline intra-peritoneally for 28 days; CH + interferon (IFN) group, CH (as above) plus pegylated IFN-alpha 2b 1.5 mu g/kg per week subcutaneously on days 0, 7, 14, 21 and 28; IFN group, pegylated IFN-alpha 2b (as above). Parietal peritoneum samples were obtained from the left anterior abdominal wall after 35 days. Parietal thickness, degree of vascular proliferation and inflammation, and MMP-2 and TIMP-2 levels were determined. The mean peritoneal thicknesses of the control, CH, CH + IFN and IFN groups were 7.02 +/- 3.89, 156.86 +/- 29.13, 59.88 +/- 22.1, 9.27 +/- 2.03 mu m, respectively. Pegylated IFN-alpha 2b decreased CH-induced expression of MMP-2 in the parietal peritoneum, but had no effect on TIMP-2 levels. Further studies are needed to determine the optimal dosage and duration for pegylated IFN-alpha 2b treatment.Öğe Expression of E-cadherin in squamous cell carcinomas of the cervix with correlations to clinicopathological features(2005) Yaldiz, M.; Hakverdi, A.U.; Bayhan, G.; Akkuş, Z.Objective: To evaluate the expression of E-cadherin, a calcium-dependent cell adhesion molecule, in a retrospective analysis of paraffin-embedded tissue specimens of cervical squamous carcinoma and the relationship with histopathological differentiation and lymph node status. Methods: In this study, we investigated by immunohistochemistry E-cadherin expression in ten normal cervical epithelia and 24 cervical invasive squamous carcinomas. Results: Normal cervical squamous epithelium showed strong expression of E-cadherin at the membrane of the cell and intercellular junctions. In 24 tumors immunnostained by E-cadherin antibody, 11 (46%) showed preserved expression and 13 (54%) reduced expression. There was no significant correlation between E-cadherin expression and histological differentiation (p = 0.650, p = 0.294). In the status of lymph node metastasis, reduced expression of E-cadherin was seen in 11/15 (73%) with lymph node metastasis versus 2/9 (22%) without lymph node metastasis. There was a significant inverse correlation between E-cadherin expression and lymph node metastasis (p = 0.032). Conclusion: Reduced E-cadherin expression may be an important factor among a variety of biologic events that occur during the process of metastasis. However, this should be explored by a large scale study.Öğe Giant congenital cellular blue naevus of the scalp with disseminated common blue naevi of the body(Wiley, 2009) Serarslan, G.; Yaldiz, M.; Verdi, M.[Abstract Not Available]Öğe Immunohistochemical analysis of p16 expression in uterine smooth muscle tumors(I R O G Canada, Inc, 2011) Hakverdi, S.; Gungoren, A.; Yaldiz, M.; Hakverdi, A. U.; Toprak, S.The expression of p16 as a tumor suppressor protein was evaluated in a retrospective analysis of paraffin-embedded tissue specimens of leiomyosarcoma (LMS), leiomyoma (LM) and normal myometrium. In this study, we investigated by immunohistochemistry p16 expression in 15 LMSs, 15 LMs and ten normal myometrium. Strong expression of p16 was found in 12 of the 15 LMSs and in three cases weak expression; three LMs had focal and weak p16 staining but none of the normal myometrium. A statistically significant difference regarding the frequency of p16 protein expression was observed between LMS and LM (p: 0.0001). We concluded that the results of this study confirm the overexpression of p16 in LMS. Therefore, the present study suggests that p16 might be a useful immunohistochemical marker which could help in distinguishing uterine LMS from LM and its benign variants.Öğe MMP7 and YKL-40 expressions in endometrial endometrioid carcinomas(I R O G Canada, Inc, 2019) Tas, Z. A.; Ozgur, T.; Yaldiz, M.; Dolapcioglu, K.Purpose of investigation: The expressions of YKL-40, MMP-7 and their relations with prognostic factors in endometrioid endometrial carcinomas (EEC) were investigated. Materials and Methods: Paraffin blocks of 50 patients diagnosed with EEC, 27 patients with endometrial hyperplasia, and 26 patients with normal cyclic endometrium were determined and the immunohistochemical staining (IHS) results of MMP-7 and YKL-40 antibodies were obtained. These results were compared with prognostic parameters with statistical evaluation. Results: Score 1 immunostaining was observed in 13 (26%), score 2 in 12 (24%), score 3 in 9 (18%), score 4 in 5 (10%) with MMP-7 in EEC. There was no MMP-7 expression in 9 (% 18) cases in carcinoma group. There was no statistically significant difference in proliferative and secretory phases in normal cycle group (p = 0.527). There was also no statistically significant difference between the non-typical and atypical hyperplasia/EIN cases (p = 0.42). Positive immunostaining was obtained in 15 (58%) of 26 normal cyclic endometrium, in 21 (78%) of 27 hyperplastic endometrium, in 19 (38%) of 50 EEC with YKL-40. The differences of YKL-40 expressions among all the groups were statistically significant (p = 0.01)). MMP-7 and YKL-40 expressions were compared with clinicopathologic parameters in the carcinoma group and found no statistical significant difference (p > 0.05). Conclusion: The present findings were limited but suggested that MMP-7 and YKL-40 might play a role in tumor progression.Öğe Multiple uterine angioleiomyomas mimicking an ovarian neoplasm: a case report(Imr Press, 2009) Hakverdi, S.; Dolapcioglu, K.; Gungoren, A.; Yaldiz, M.; Hakverdi, A. U.Angioleiomyoma is a rare benign neoplasm that originates from smooth muscle cells and contains thick-walled blood vessels. A 69-year-old woman had been complaining of progressive abdominal distention for the last five years. At the exploration, a tumoral mass that could not be differentiated as to whether it had its origin from the uterus or ovary was specified. The patient underwent total hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO). On pathologic examination of the specimen, the tumor was diagnosed as an angioleiomyoma. Here, we present a case of giant-multiple uterine angioleiomyomas mimicking an ovarian neoplasm.Öğe Non-infectious erythematous papular and squamous lesions of the skin in our institute, with clinicopathologic correlation(Springer, 2012) Ozgur, T.; Dogramaci, A. C.; Atik, E.; Hakverdi, S.; Yaldiz, M.; Tas, Z. A.[Abstract Not Available]
