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Öğe Adult T-cell acute lymphoblastic leukemia; skin involvement: Case report(Turkiye Klinikleri, 2015) Şen, Tu?ba; Şen, Bilge Bülbül; Yaldiz, Mehmet; Rifaio?lu, Emine Nur; Ekiz, Özlem; Taş, Zeynel Abidin; Kaya, HasanT-cell acute lymphoblastic leukemia (T-ALL), derived from precursor T cell, is a hematologic malignancy which spreads over the extramedullary organs. Skin metastasis of leukemia; leukemia cutis, rarely seen in T-cell leukemia, is infiltration of skin by malign leukemic cells. A thirty-three years old woman who diagnosed as T-ALL one year ago was consulted to our department for skin lesions. In dermatological examination, erythematous brownish nodules and tumors were observed on her face, body and extremities. The lesions were evaluated as T-ALL skin involvement according to histopathological investigation. Chemotherapy was initiated to the patient. After treatment, noduler and tumoral lesions became smaller. However, the patient died because of sepsis. In conclusion, T-ALL which is a malignant hematological disease characterized by bone marrow and internal organ involvement rarely metastases to the skin. Skin involvement of T-ALL indicates poor prognosis. We present this case who has widespread skin lesions because it is rarely seen.Öğe The Biocompatibility of Nitinol in Knee Joint Spaces and Femoral Tunnels: An Experimental Study in Rats(Journal Hard Tissue Biology, 2014) Kalacı, Aydıner; Uruc, Vedat; Ozden, Raif; Duman, Ibrahim Gokhan; Dogramaci, Yunus; Karapinar, Serhat; Yaldiz, MehmetCurrently the most common method of reconstructing a ruptured anterior cruciate ligament (ACL) is by using bone-patellar tendon-bone (BPTB) or semitendinosus, gracilis tendon autografts. Although good results are reported, donor morbidity continues to be a problem. To overcome these complications, synthetic grafts have been investigated. However, to date no prosthetic graft has been developed as an alternative to patellar or hamstring tendon autografts. The aim of the present study was to assess the biocompatibility of nitinol in rat knee joint spaces and distal femoral bones. Ten male, healthy Wistar albino rats, weighing between 300-350 g, were used. The right knee joint of each rat was reached by medial longitudinal parapatellar dissection. The femur distal was penetrated by a size 0.5 mm of Kirshner wires. Twenty nitinol wires were placed in the bone tunnel (0.125 mm in diameter and 5 mm long). In addition one nitinol wire was placed in the joint space. Following hemostasis, the layers were closed with interrupted sutures. The same procedure was repeated for the left side without placing any nitinol wire. The rats were allowed unrestricted weight bearing. Two animals died of unknown reasons during follow-up. The remaining rats were sacrificed 8 weeks after surgery. The knees were removed by careful dissection and the nitinol wires were removed. The sections taken from these specimens were stained with Standard hematoxylin and eosin and with Mason trichrome and examined under the light microscope. The bone tunnels were filled with osteocytes and chondrocytes. In two specimens of the nitinol group, moderate synovitis was detected. The synovitis rate in the study group was found to be statistically insignificant. In conclusion, the short term biocompatibility of nitinol in the rat knee joint space and femoral tunnel was found to be within acceptable limits.Öğe A Case of Asymptomatic Riedel Thyroiditis with Follicular Adenoma in a Patient with a Multinodular Goiter: An Unusual Association(Bioscientifica Ltd, 2012) Ozgur, Tumay; Gokce, Hasan; Ustun, Ihsan; Yaldiz, Mehmet; Akin, Mehmet Mustafa; Gokce, CumaliBackground: Riedel's thyroiditis (RT) is a rare inflammatory disease that results in fibrosis of the thyroid gland and invasion to the surrounding structures of the neck. Follicular adenoma (FA) of the thyroid is the most common benign neoplasm of the gland. Patient Findings: A 42-year-old woman was referred to the outpatient clinic due to a multinodular goiter and thyroiditis. The patient was euthyroid and thyroid function tests were within normal limits. Thyroid antibodies (thyroid peroxidase antibody and thyroglobulin antibody) were high. Thyroid ultrasonography showed multiple iso-hypoechoic nodules and thyroiditis. Fine-needle aspiration cytology was performed, and it was consistent with 'suspicious for a follicular neoplasm' according to the Bethesda system. Due to the clinical findings, which included weight loss and sweating, and the cytological results indicative of a follicular neoplasm, the patient underwent a total thyroidectomy. The histopathological diagnosis was RT associated with FA. The patient was started on thyroid hormone (thyroxine) replacement therapy after surgery and was evaluated for additional fibrosis related to RT. Conclusions: To our knowledge, this is the first case of RT associated with FA in an asymptomatic patient with a multinodular goiter and high thyroid antibodies reported in the literature. Copyright (C) 2012 European Thyroid Association Published by S. Karger AG, BaselÖğe A case of atypical scleromyxedema mimicking angioedema which responded well to acitretin treatment(Deri Zuhrevi Hastaliklar Dernegi, 2015) Ekiz, Ozlem; Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Yaldiz, MehmetA 37-year-old male patient was admitted our clinic with the complaints of edema and mild pruritus of the eyelids, ears, and the neck. On dermatological examination, there were edema and pale erythema on the eyelids and ears as well as coarsening of the facial features and lines grooving the forehead. His medical history revealed that the patients received systemic corticosteroids, antihistamines and epinephrine treatments for about two months with the diagnosis of urticaria and angioedema, however, he did not benefit from these treatments. A diagnosis of atypical scleromyxedema without monoclonal gammopathy was established according to the clinical, histopathological and laboratory findings. Acitretin treatment with a dose of 35 mg/day was started. Marked regression in the lesions was observed two months later.Öğe Descriptive epidemiology of non-hodgkin's lymphomas in Hatay(2013) Özgür, Tümay; Yaldiz, Mehmet; Kaya, Hasan; Yengil, Erhan; Toprak, SerhatThe incidence of Non-Hodgkin's Lymphomas (NHL) varies among different parts of the world. NHL are the 12th most common cancer in Europe and increasing dramatically during the last years. In this study, it was aimed to analyse the descriptive epidemiology of NHL in Hatay region with retrospective archieve datas. One hundred and thirty-three NHL cases between 2005 and 2013 have been reviewed retrospectively in the Pathology Department of the Mustafa Kemal University. All of the cases were classified according to World Health Organization modified in 2008. Eighty-two (61.7%) cases were male and 51 (38.3%) cases were female. Ninety-two of the cases (69.2%) were nodal lymphoma, and the remaining 41 (30.8%) were extranodal lymphoma. The most common extranodal involvement regions were tonsils and nasopharynx with frequencies of 21.9% (9) and 19.5% (8), respectively. The age distribution pattern revealed that NHL were mostly diagnosed in the ages of 41-65 years in nodal (41.3%) and extranodal sited NHL groups (53.6%). The most frequent NHL was diffuse large cell B cell lymphoma (50.4%) and chronic lymphocytic leukemia/small lymphocytic lymphoma (17.3%). Our results were similar with the literature. Further epidemiologic studies with larger series defining the profile of NHL subtypes may be more worthy.Öğe Do histopathologic findings improve by increasing the sample size in cholecystectomies?(Biomed Central Ltd, 2013) Ozgur, Tumay; Toprak, Serhat; Koyuncuer, Ali; Guldur, Muhammed; Bayraktar, Gurman; Yaldiz, MehmetBackground: Gallbladder diseases present with cholelithiasis in a wide spectrum of adenomas and cancers. Two or three specimens are sampled in cholecystectomies in routine pathology practice. The aim of this study was to investigate the increase in frequency of histologic alterations in cholecystectomies, particularly precancerous lesions, by increasing the sample size to understand the carcinoma pathway. Methods: Cholecystectomies of 432 patients with pathology records and materials from two medical centers were collected, and two groups were created. Initial data with two or three samples were allocated to Group 1 and the new six samples with the initial ones were allocated to Group 2. Hematoxylin and eosin (H&E) sections were examined for histopathologic alterations, and periodic acid-Schiff (PAS) Alcian blue (pH 2.5) and high iron diamine (pH 2.5) stains were used to signify the mucin profile in case of metaplasias. For the comparison of findings, non-parametric tests, McNemar's tests, chi-squared tests and Fisher's exact test were performed. Results: Of the 432 patients, 308 (71.3%) patients were female and 124 (28.7%) patients were male. The mean age of patients was 47.9 +/- 14.6 years. Cholesterolosis was observed in 95 (22%) patients in Group 1 and 108 (25%) patients in Group 2. Gallstones were detected in 255 (59%) of the cholecystectomies. There was a significant difference between Group 1 and Group 2 by increasing the sample size when we compared cholesterolosis, metaplasia and polyps (P < 0.05). Cholecystitis and dysplasia rates were the same in both of the groups. There was no cancer determined. Conclusion: Increasing the sample size in cholecystectomies increased the diagnosis of some histologic alterations, but further studies with a larger number of samples over a longer period time might increase the ability to determine precancerous lesions and concomitants.Öğe Does cyclin E and p57kip2 expression have prognostic and survival value in colorectal adenocarcinoma?(E-Century Publishing Corp, 2018) Ozgur, Tumay; Sumbul, Ahmet Taner; Yaldiz, Mehmet; Temiz, Muhyittin; Akdag, AbdurrahmanIntroduction: Colorectal cancer is still one of the main causes of cancer death in the world. There is a continous need for novel biomarkers for diagnose, treatment modalities and follow-up. Cyclin E and p57(KIP2) as the positive and negative regulators of cell cycle seem to be an important target for investigations. Materials and methods: In a retrospective setting, primary colorectal adenocarcinoma cases examined in Mustafa Kemal University, School of Medicine, Pathology Department between 2008-2015 were reviewed. Immunohistochemical expressions of cyclin E and p57(KIP2) in 80 pairs of colorectal carcinoma and adjacent normal mucosal tissues were evaluated and the findings were compared with clinicopathological parameters and survival time. Results: There were no statistically significant difference between two groups both in cyclin E and p57(KIP2) stained tissues (P>0.05). There were 40 (50%) patients in high-expression group and 40 (50%) patients in low-expression group for cyclin E. P57(KIP2) was negative in 55 (68.75%) patients and positive in 25 (31.75%) patients. There were no statistically significant relation between p57(KIP2) and cyclin E expressions with clinicopathologic parameters defined as age, gender, lymphovascular invasion, perineural invasion, depth of invasion, nodal involvement, emergency in operation, perforation before operation and overall survival except that there was significant relation between p57(KIP2) expression and histological grade (P=0.012). Conclusions: Immunohistochemical studies of cyclin E and p57(KIP2) should be performed with larger series of patients supported by more detailed technical research methods to be candidates as predictive markers for treatment modalities and prognostic factors.Öğe Erythrokeratodermia variabilis: Successful palliative treatment with acitretin(Wolters Kluwer Medknow Publications, 2008) Balci, Didem Didar; Yaldiz, Mehmet[Abstract Not Available]Öğe Evaluation of Fetal Autopsy Findings in the Hatay Region: 274 Cases(De Gruyter Open Ltd, 2012) Hakverdi, Sibel; Guzelmansur, Ismail; Gungoren, Arif; Toprak, Serhat; Yaldiz, Mehmet; Hakverdi, Ali UlviObjective: The aim of this study was to present the incidence of fetal anomalies in our region of Hatay, Turkey in order to determine the efficiency of prenatal diagnosis through fetal autopsy, and to compare our statistical data with other national and international studies. Material and Method: This study was conducted on 274 fetuses from terminated pregnancies due to abnormal prenatal findings and intrauterine deaths from 2005 to September 2010. Fetuses were evaluated through postmortem examination, external measurements, X-rays, Magnetic Resonance Images, Multislice Computerized Tomography and photographs. The autopsy was completed by the histological examination of each organ. Results: Autopsy was conducted on 274 fetuses. A fetal anomaly was detected in 160 (58.39%) cases. The central nervous system contained the most frequent structural defects (79 cases, 49.38%), followed by malformations in the musculoskeletal system in 36 cases (22.5%). The most frequent multiple system anomalies were central nervous system defect and bilateral adrenal agenesis, musculoskeletal system malformations and urinary system defects. Fetal autopsy provided additional findings in 43 cases (26.88%). Conclusion: Fetal autopsy is a very important procedure and an integral part of the general prenatal management. New findings through this method may suggest invaluable data for parents about potential risks in future pregnancies.Öğe The expressions of AMACR and iNOS in prostate adenocarcinomas(Professional Medical Publications, 2013) Ozgur, Tumay; Atik, Esin; Hakverdi, Sibel; Yaldiz, MehmetBackground and Objective: Prostate cancer is the second leading cause of death in men. The localized disease often responds to conventional therapies like androgen ablation via castration and/or administration of chemical inhibitors but advanced disease resistant to any curative therapies is still challenge for investigators. There are increasing efforts to enhance the possibility of finding positive and sensitive immune markers for diagnosing and treating prostate cancer. The aim of this study was to investigate the expression patterns of AMACR and iNOS in prostate adenocarcinomas with different histopathologic grade. Methodology: We applied immunohistochemical markers; AMACR and iNOS. Formalin-fixed parafin embedded tissues of 64 prostate needle biopsy specimens diagnosed as prostate adenocarcinoma between 2005-2010 years were included in the study. Results: AMACR expression were found in 58 (90.6%) and iNOS expression in 54 (84.4%) of 64 prostate adenocarcinomas. No significant relationship of AMACR and iNOS was obtained (p > 0.05). There was no significant correlation of histopathologic grade of the tumors with AMACR and iNOS expression (p > 0.05). Conclusions: The expression of AMACR and iNOS might be important diagnostic immune markers for prostate adenocarcinomas especially in needle biopsies where the quantity and quality of tissue are limited.Öğe Gastric infection by Strongyloides stercoralis: A case report(Aves, 2009) Yaldiz, Mehmet; Hakverdi, Sibel; Aslan, Ahmet; Temiz, Muhittin; Culha, GuelnazStrongyloides stercoralis is an intestinal nematode with a complex life cycle that involves colonizing and reproducing in the upper small intestinal mucosa. In a healthy host, the parasite usually does not cause any symptoms. We report a gastric infection case of S. stercoralis. A 72-year-old Turkish man was admitted to the Department of General Surgery with complaints of epigastric pain, nausea and vomiting for five days. Upper gastrointestinal endoscopy evidenced a diffuse infiltrate in the stomach, causing decreased distensibility. Microscopically, superficial chronic inflammation with hyperplastic reactive changes and damaged surface was observed. Histopathological examination of the gastric mucosa showed numerous cross-sections of adult worms, eggs and rhabditiform larvae of S. stercoralis developing in the gastric crypts.Öğe Glomus tumor of the hip An unusual location(Saudi Med J, 2009) Hakverdi, Sibel; Kalacı, Aydıner; Yaldiz, Mehmet; Akansu, BülentGlomus tumors are usually benign neoplasms that occur in the dermis or subcutaneous tissues of the extremities. They occur very rarely in the hip. We report a patient with severe pain and tenderness in the left hip, especially on palpation, and in the sitting position. On physical examination, there was a soft palpable Subcutaneous mass and severe tenderness in the left hip. Ultrasound revealed a hypervascular subdermal mass that was 1.2 cm in diameter, which was subsequently totally excised under local anesthesia. The histopathologic diagnosis was a 'glomus tumor'. The patient has been symptom-free for 3 months of follow-up.Öğe Glomus tumor of the hip. An unusual location(2009) Hakverdi, Sibel; Kalacı, Aydıner; Yaldiz, Mehmet; Akansu, BülentGlomus tumors are usually benign neoplasms that occur in the dermis or subcutaneous tissues of the extremities. They occur very rarely in the hip. We report a patient with severe pain and tenderness in the left hip, especially on palpation, and in the sitting position. On physical examination, there was a soft palpable subcutaneous mass and severe tenderness in the left hip. Ultrasound revealed a hypervascular subdermal mass that was 1.2 cm in diameter, which was subsequent totally excised under local anesthesia. The histopathologic diagnosis was a 'glomus tumor'. The patient has been symptom-free for 3 months of follow-up.Öğe Intracranial meningiomas: Two-years experience of Mustafa Kemal University(Ondokuz Mayis Universitesi, 2013) Özgür, Tümay; Altas, Murat; Aras, Mustafa; Atik, Esin; Yaldiz, Mehmet; Yilmaz, NebiMeningiomas are the most common type of brain tumors. We have analyzed clinical, radiological and pathological characteristics of meningiomas that were diagnosed and operated in our centre. Twenty three meningioma cases operated in our hospital between 2010-2012 were reviewed retrospectively. Sixteen (69.1%) of cases were female and 7 (30.9%) of cases were male. The age range was 22-75. The most common symptoms of patients were headache, seizure, nausea and vomitting. Localizations of tumors were falx, cortex, sphenoid wing, posterior fossa-tentorium, olphactor, and sulcus. The surgical sizes were graded according to Simpson classification and 16 (69.1%) of cases were Grade 2 and 7 (30.9%) of cases were Grade I. At the histopathological examination; meningotheliomatous type was the most common type followed by fibrous, angiomatous, transitional, psammomatous and atypical types. Meningiomas are usually benign tumors with good prognosis which are often encountered in daily pathology and neurosurgery practice. © 2013 OMU.Öğe Malignant sarcomatous mural nodule associated with ovarian serous cystadenoma: Case report and review of literature(2011) Hakverdi, Sibel; Güngören, Arif; Hakverdi, Ali Ulvi; Dolapçio?lu, Kenan; Yaldiz, Mehmet; Bayramo?lu, NeslihanWe present a rare case of ovarian serous cystadenoma with malignant mural nodules. The patient, a 76-year-old woman, was admitted to our hospital with right lower abdominal pain and swelling which was going on for 4 months. A gross tumor, measuring 20 x 15 x 7 cm in size and containing solid and cystic areas, was found and removed. Inner surface revealed a poor-circumscribed nodule measuring 7 x 5 cm. Areas of hemorrhage and necrosis in the nodule were noted. Histopathologic examination of the mass showed cystadenoma with malignant mural nodule. Cases of ovarian serous tumors associated with mural nodules are very rare, and this is the ninth reported case so far. Copyright © 2011 by Türkiye Klinikleri.Öğe miR-204-5p expression in colorectal cancer: an autophagy-associated gene(Sage Publications Ltd, 2014) Sumbul, Ahmet Taner; Gogebakan, Bulent; Ergun, Sercan; Yengil, Erhan; Batmaci, Celal Yucel; Tonyali, Onder; Yaldiz, MehmetMicroRNAs (miRNAs) are important factors during tumorigenesis by affecting posttranscriptional gene expression. miRNA 204 (miR-204) is a miRNA frequently investigated in different types of cancers. According to literature, autophagy has dual roles in cancer, acting as both a tumor suppressor and cell survival agent. Also, the current data suggests that autophagy is activated in human colorectal cancer cells and enhances the aggressiveness of human colorectal cancer cells. So, our aim is to investigate potential effect of miR-204-5p on colorectal cancer by associating its expression with autophagy-related targets of miR-204-5p. This is the first miRNA study conducted on patients with colorectal cancer and healthy subjects and also to search the relation of miR-204-5p with clinicopathological factors and survival. Sixty-six patients with colorectal cancer and healthy subjects without any known chronic disease were enrolled into our study. Total miRNA was isolated from paraffin-embedded tissues of all patients' cancerous and normal tissues, and healthy subjects. cDNAs were obtained from this miRNAs by reverse transcriptase method, and miR-204-5p relative expression levels were detected by qRT-PCR method. Patients were divided into two groups according to median relative expression levels of miR-204-5p, as low-and high-expression group. Relation of miR-204-5p with clinicopathological factors and overall survival was also investigated. Medians of miR-204-5p relative expression levels in cancerous and normal tissues of patients were found as 0.00235 and 0.00376, respectively. The difference between two groups was not statistically significant (p=0.11). Nonetheless, median of miR-204-5p relative expression levels in healthy subjects were found as 0.00135, and the difference between patient with cancer and healthy subjects and between normal tissues of patients and healthy subjects were statistically significant (p=0.021 and p=0.0005, respectively). There were 32 patients (48.5 %) showing high expression and 34 patients (51.5 %) showing low expression according to miR-204-5p relative expression levels. There were no statistically significant relation between clinicopathologic features and miR-2045p relative expression levels. We also investigated the relation between miR-204-5p relative expression levels and overall survival, and no statistically significant relation was found between them (p=0.462). The absence of any significant difference between tumor and non-tumor samples, low sample size, and performance at just one center are the limitations of our study. In opposition to literature, miR-204-5p is overexpressed in colorectal cancer patients as compared with healthy subjects and this situation is not associated with clinicopathological factors and overall survival. This may be explained by the fact that miR-204-5p increases in colorectal cancer cases in order to inhibit increased activity of LC3B-II in autophagy and Bcl2 against apoptosis posttranscriptionally and to take role as tumor suppressor.Öğe Primary peripheral primitive neuroectodermal tumour of the orbit(Canadian Ophthal Soc, 2007) Tamer, Cengaver; Oksuz, Huseyin; Hakverdi, Sibel; Karazincir, Sinem; Balcı, Ali; Yaldiz, MehmetCase report: We present the clinical, radiologic, and histopathologic features of an orbital mass in a 10-year-old boy. Immunohistochemistry confirmed the diagnosis of primary peripheral primitive neuroectodermal tumour. Comments: This recently recognized rare tumour of the orbit should be considered in the differential diagnosis of hypercellular small round cell tumour of the orbit.Öğe Problem of cystic echinococcoss in Hatay(2008) Hakverdi, Sibel; Culha, Gülnaz; Canda, M Serefettin; Yaldiz, Mehmet; Altintaş, SüleymanEchinococcosis is a zoonotic infection caused by Echinococcus granulosus and E. multilocularis. It continues to be a serious public health problem in many countries including Turkey. In Hatay, no previous study has been carried out; therefore, in this study, in order to determine its prevalence and to attract scientific attention to this issue, we have retrospectively evaluated cases of cystic echinococcosis in human patients presenting at the pathology laboratory of the Mustafa Kemal University, Faculty of Medicine, Research Hospital, as well as Antakya and Iskenderun State Hospitals. We have identified a total of 26 cases, of which 18 were in female patients (69.23%) and 8 in male patients (30.76%). The highest rate of cystic echinococcosis was found in the liver (57.6%), and lungs (19.23%). It was also found in the peritoneal region, spleen, cervical region, muscle, and an incision scar. In addition, the presence of cystic echinococcosis was investigated in 35,812 cattle slaughtered in Antakya slaughterhouse and 5,448 (3.23%) were found to have cystic echinococcosis.Öğe The Protective Effect of Ebselen on Radiocontrast-Induced Nephrotoxicity(Taylor & Francis Ltd, 2012) Ozgur, Tumay; Tutanc, Murat; Zararsiz, Ismail; Motor, Sedat; Ozturk, Oktay Hasan; Yaldiz, Mehmet; Kurtgoz, Ozgur YildirimAim: Radiocontrast-induced nephropathy has become one of the most important causes of renal acute failure. The most effective management of reducing the incidence of contrast nephropathy is to understand and prevent its causes. We aimed to investigate the protective role of ebselen against radiocontrast-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Methods: Albino Wistar rats were randomly separated into four groups. The Group 1 rats were treated with sodium chloride as the control group, Group 2 with radiocontrast, Group 3 with radiocontrast plus ebselen, and Group 4 with ebselen alone. After 24 h, the animals over the experimental period were euthanized and blood samples were analyzed for blood urea nitrogen (BUN) and serum creatinine (Cr) levels. Kidney sections were analyzed for malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as histopathological changes. Results: In the radiocontrast group, BUN, MDA, and GSH-Px levels increased while SOD activity decreased compared with the control group. These decays were improved by ebselen administration in the radiocontrast group. Significant histological deteriorations were observed in the radiocontrast group. We noted improvement in the histologic findings with ebselen administration. Conclusion: These results indicate that ebselen might produce a protective mechanism against radiocontrast-induced nephrotoxicity.Öğe Protective Effects of Intralipid and Caffeic Acid Phenethyl Ester on Nephrotoxicity Caused by Dichlorvos in Rats(Hindawi Ltd, 2015) Celik, Muhammet Murat; Alp, Ayse; Dokuyucu, Recep; Zemheri, Ebru; Ozkanli, Seyma; Ertekin, Filiz; Yaldiz, MehmetThe protective effects of Caffeic Acid Phenethyl Ester (CAPE) and intralipid (IL) on nephrotoxicity caused by acute Dichlorvos (D) toxicity were investigated in this study. Forty-eight Wistar Albino rats were divided into 7 groups as follows: Control, D, CAPE, intralipid, D + CAPE, D + IL, and D + CAPE + IL. When compared to D group, the oxidative stress index (OSI) values were significantly lower in Control, CAPE, and D + IL + CAPE groups. When compared to D + IL + CAPE group, the TOS and OSI values were significantly higher in D group (P < 0.05). When mitotic cell counts were assessed in the renal tissues, it was found that mitotic cell count was significantly higher in the D group while it was lower in the D + CAPE, D + IL, and D + IL + CAPE groups when compared to the control group (P < 0.05). Also, immune reactivity showed increased apoptosis in D group and low profile of apoptosis in the D + CAPE group when compared to the Control group. The apoptosis level was significantly lower in D + IL + CAPE compared to D group (P < 0.05) in the kidneys. As a result, we concluded that Dichlorvos can be used either alone or in combination with CAPE and IL as supportive therapy or as facilitator for the therapeutic effect of the routine treatment in the patients presenting with pesticide poisoning.
