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    Alterations in serum levels of trace elements in Cutaneous leishmaniasis patients in endemic region of Hatay (Antioch)
    (Asian Journal Of Chemistry, 2008) Culha, Gulnaz; Yalin, Erdinc; Sanguen, Kemal
    Immune cells, like all other types of cells, require an adequate supply of trace elements for the structure and function of metalloproteins that participate in housekeeping processes such as energy production and protection against reactive oxygen species. In addition, trace elements are required for the activity of a number of enzymes that directly participate in host defense processes. In the present study we evaluated the alterations of zinc, copper, selenium and iron concentrations in serum of patients treated with meglumine antimonate (glucantime) and untreated cutaneous leishmaniasis. Serum levels of zinc, copper, selenium and iron were measured by atomic emission spectrometer. The serum levels of these elements were found to be significantly higher in untreated patients compared to those of healthy controls. However, the levels of zinc, copper and iron in serum were significantly reuced and selenium levels were increased in treated patients. These suggest that the increasing levels of trace elements in serum may be host defense strategies of organism infection. In addition the high trace element levels were a sequel of the disease rather than a cause.
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    Oxidative stress and antioxidant enzyme activities in patients with cutaneous leishmaniasis in endemic region of Hatay (Antioch)
    (Asian Journal Of Chemistry, 2007) Culha, Gulnaz; Yalin, Erdinc; Yalin, Serap; Eroglu, Pelin; Berkoz, Mehmet
    Leishmania is the collective name for a number of disease caused by protozoon flagellates of genus Leishmania which have diverse clinical manifestations. In this study, we investigated the effect of free radicals and antioxidants on cutaneous leishmaniasis (CL). Venous blood samples of patients and controls were collected and analyzed for serum nitric oxide (NO) and malondialdehyde, (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities. 53 treated CL patients, 42 untreated patients,and 30 healty control subjects were enrolled in this study. The levels of MDA and NO showed a significant increase (p < 0.05) in the untreated patients when compared to the treated patients and control groups. In the untreated group, the activities of both SOD and CAT were found to be decreased (p < 0.05) compared with values in the control and treated groups. After the treatment, NO and MDA levels were decreased whereas the activities of CAT and SOD were increased. These results provide some evidence for a potential role of increased lipid peroxidation and decreased enzymatic antioxidants in cutaneous leishmaniasis. These results suggested that oxidant stress plays an important role in the pathogenesis of cutaneous leishmaniasis.
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    Oxidative stress and antioxidant enzyme activities in patients with cutaneous leishmaniasis in endemic region of Hatay (ANTIOCH)
    (Chemical Publishing Co., 2007) Culha, Gulnaz; Yalin, Erdinc; Yalin, Serap; Eroglu, Pelin; Berkoz, Mehmet
    Leishmania is the collective name for a number of disease caused by protozoon flagellates of genus Leishmania which have diverse clinical manifestations. In this study, we investigated the effect of free radicals and antioxidants on cutaneous leishmaniasis (CL). Venous blood samples of patients and controls were collected and analyzed for serum nitric oxide (NO) and malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities. 53 treated CL patients, 42 untreated patients and 30 healty control subjects were enrolled in this study. The levels of MDA and NO showed a significant increase (p < 0.05) in the untreated patients when compared to the treated patients and control groups. In the untreated group, the activities of both SOD and CAT were found to be decreased (p < 0.05) compared with values in the control and treated groups. After the treatment, NO and MDA levels were decreased whereas the activities of CAT and SOD were increased. These results provide some evidence for a potential role of increased lipid peroxidation and decreased enzymatic antioxidants in cutaneous leishmaniasis. These results suggested that oxidant stress plays an important role in the pathogenesis of cutaneous leishmaniasis.