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Öğe Dermatoglyphs in patients with psoriasis(Wiley-Blackwell Publishing, Inc, 2010) Dogramaci, A. C.; Yenin, J. Z.; Bagriacik, M. A.; Savas, N.[Abstract Not Available]Öğe Identification of Helicobacter pylori by Urea Breath test and serology in the patients with psoriasis(Wiley-Blackwell, 2016) Balci, D. D.; Yalcin, H. Peker; Ozer, B.; Duran, N.; Inan, M. U.; Yenin, J. Z.[Abstract Not Available]Öğe Increased macrophage migration inhibitory factor in Behcet's disease and relation with the disease activity(Wiley, 2009) Serarslan, G.; Sogut, S.; Yonden, Z.; Oksuz, H.; Savas, N.; Yenin, J. Z.; Arpaci, A.[Abstract Not Available]Öğe Investigation of oxidative stress in patients with alopecia areata and its relationship with disease severity, duration, recurrence and pattern(Wiley, 2015) Yenin, J. Z.; Serarslan, G.; Yoenden, Z.; Ulutas, K. T.Background Alopecia areata (AA) is an inflammatory autoimmune disease that causes hair loss on the scalp or trunk without scarring. Although the precise aetiopathogenesis of alopecia areata remains unknown, oxidative stress is thought to play a role. Aim To investigate the relationship between severity and the role of oxidative stress in AA, by measuring plasma oxidant levels and antioxidant enzyme activities in erythrocytes. Methods In total, 62 patients with AA (24 males and 38 females), and 62 sex- and age-matched healthy controls (HCs) were enrolled in the study. We investigated the levels of plasma malondialdehyde (MDA) and the activities of erythrocyte catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). The relationship between oxidative stress and AA was also investigated with regard to disease pattern, severity, duration and recurrence. Results The mean erythrocyte GSH-Px and SOD activities were significantly reduced (P<0.001 and P<0.001 respectively) compared with the control group. Plasma MDA levels were increased but statistically insignificant (P=0.08) in patients with AA compared with controls. No significant difference between erythrocyte CAT activities was observed between patients and controls (P=0.2). In addition, we observed no statistically significant difference in patient plasma MDA levels or erythrocyte CAT, GSH-Px or SOD activities with regard to AA severity, duration, recurrence or pattern (P>0.05). Conclusions Patients with AA displayed reduced erythrocyte SOD and GSH-Px activities and enhanced plasma MDA levels. These findings support the possible role of oxidative stress in the pathogenesis of AA.Öğe Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study(Wiley-Blackwell, 2012) Serarslan, G.; Savas, N.; Yenin, J. Z.Objective We aimed to determine whether there was a difference between adult and paediatric alopecia areata patients with respect to the severity and pattern of the disease, nail changes and personal and family history of autoimmune diseases and also in comparison with controls. Methods Two groups were included: patients with onset of alopecia before the age of =18 years and >18 years. The total number of the patients were 124. The control group was comprised of 114 age- and gender-matched patients. Results There were 81 adults and 43 children. No statistically significant difference was present between disease severity and gender, age, personal and family history of autoimmune disease in the adult and paediatric group (P > 0.5). Thirteen adults with scalp involvement had nail changes. 61.5% had mild and 38.46% had severe disease (P > 0.5). Of the 43 paediatric patients, 10 patients had nail changes. Severe alopecia was present in 40% of patients with nail changes; however, 9.1% had severe alopecia in patients without nail changes (P = 0.04). There was no statistical significance in patients with and without familial autoimmune diseases when compared with pattern and severity of the diseases between the two groups. Conclusion The frequencies of autoimmune and atopic diseases were not different between adult and paediatric patients and the control group. We did not find a statistically significance between disease severity and personal and family history of autoimmune disease in the two groups. Disease severity was not related to nail changes in the adult group. However, severe alopecia areata was more prevalent in children with nail changes. Furthermore, ophiasis pattern was more prevalent in the paediatric group with nail changes compared with the adult group.
