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Öğe A Case of Nonhealing Leg Ulcer: Basal Cell Carcinoma(Galenos Yayincilik, 2008) Balci, Didem Didar; Yenin, Julide Zehra; Atik, Esin; Akansu, BulentA 75-year-old woman was admitted to our outpatient clinic with a three-year history of a painless, nonhealing ulcer located on the left lower leg. She had no response to previous therapy with local wound care. Skin examination revealed an ulcer 2.7 x 3.7 cm in size, and the surrounding skin showed minimal erythema. The surface of the ulcer demonstrated shiny granulation tissue. Biopsy of the ulcer edge and base showed basal cell carcinoma. Venous Doppler ultrasonography and dermatological examination did not reveal chronic venous insufficiency. Basal cell carcinomas rarely arise from previous long-term ulcers or developing de novo. We suggest that patients who develop non-healing leg ulcers, should be examined for basal cell carcinoma.Öğe The Co-Existence of Vulvar Lichen Sclerosus, Ulcerated Calcinosis Cutis, and Dermatomyositis: Coincidence or Immunological Mechanism?(Korean Dermatological Assoc, 2011) Balci, Didem Didar; Celik, Ebru; Sarikaya, Gokhan; Yenin, Julide Zehra; Atik, EsinCalcinosis cutis is a condition characterized by the deposition of calcium salts in the skin and subcutaneous tissues, and patients suffering from it encounter various connective tissue disorders, such as dermatomyositis (DM), scleroderma, and systemic lupus erythematosus. Although calcinosis cutis is frequently accompanied by juvenile dermatomyositis, rare cases have been reported in adult patients with DM. On the other hand, lichen sclerosus (LS) is a chronic inflammatory disease of the skin and mucosal surfaces. In the present report, we present a rare case of a 71-year-old patient with DM accompanied by ulcerated calcinosis cutis and vulvar LS. (Ann Dermatol 23(S3) S375 similar to S379, 2011)Öğe The Evaluation of Solid Phase Gastric Emptying in Patients with Behcet's Disease(Derman Medical Publ, 2015) Dogramaci, Asena Cigdem; Yalcin, Hulya; Balci, Didem Didar; Ucar, Edip; Yenin, Julide Zehra; Kalender, EbuzerAim: Behcet's disease is a multisystemic disease that includes the mucocutaneous, ocular, cardiovascular, renal, pulmonary, joint and central nervous system involvement. Gastrointestinal system involvement is rare in Behcet's disease. Current study was planned to investigate the rate of gastric emptying in patients with Behcet's disease by using gastric emptying scintigraphy. Material and Method: In order to determine gastric emptying rate of solids, 14 patients with Behcet's disease and 14 healthy controls were studied scintigraphically. After an overnight fast, all subjects ingested a Tc-99m DTPA labeled solid meal consisted of an egg and toasted white bread. Immediately after ingestion of the meal, subjects were positioned supine under the gamma camera and serial images were recorded continuously for 90 minutes. Half empyting time (t 1/2) and percentage of radioactive material remaining in the stomach at 60 min. were calculated. Results: The mean ages of Behcet's patients was 41.00 +/- 10.25 years and 40.57 +/- 10.05 years in control group. T 1/2 of Behcet's patients was found 85 +/- 61 min. and 63 +/- 22 min. in control cases (p=0.122). Percentage of radioactive material remaining in the stomach at 60 min. was 69.3 +/- 14.0 % and 54.6 +/- 22.0 % in Behcet's patients and controls, respectively (p=0.035). Discussion: Although there was not a significant difference between half gastric emptying times, we determined that percentage of radioactive material remaining in the stomach at 60 min. was significantly greater in Behcet's patients than that in controls. As a result, gastric stasis could be seen in Behcet's patients due to multisystemic involvement.Öğe The evaluation of solid phase gastric emptying in patients with Behcet’s disease(2015) Doğramacı, Asena Çiğdem; Yalçın, Hülya; Balcı, Didem Didar; Uçar, Edip; Yenin, Julide Zehra; Kalender, EbuzerAmaç: Behçet Hastalığı mukokutanöz sistem, göz, kardiyovasküler sistem, böbrek, akciğer, eklem ve merkezi sinir sistemi tutulumu ile seyredebilen multisistemik bir hastalıktır. Behçet Hastalığında gastrointestinal sistem tutulumu nadirdir. Bu çalışmada mide boşalma sintigrafisi ile Behçet Hastalarında mide boşalma oranlarının araştırılması amaçlandı. Gereç ve Yöntem: Solid mide boşalma oranlarının tesbiti amacıyla 14 Behçet Hastası ile 14 sağlıklı kontrol grubu sintigrafik olarak incelendi. Bir gece açlıktan sonra tüm olgular Tc-99m DTPA ile işaretli yumurta ve kızarmış beyaz ekmekten oluşan solid gıda aldı. Yemek yenilmesinden hemen sonra olgular gamma kamera altı- na sırt üstü yatırıldı ve 90 dakika boyunca sürekli görüntüler alındı. Mide yarı boşalma zamanı (T ½) ve 60. dakikada midede kalan radyoaktif madde oranı hesaplandı. Bulgular: Behçet Hastalarının ortalama yaşı 41.00±10.25, kontrol grubunun ise 40.57±10.05 idi. Behçet Hastalarının T ½ değeri 85± 61 dakika olarak bulunurken kontrol vakalarında 63±22 dakika olarak bulundu (p=0.122). 60. dakikada midede kalan radyoaktif madde oranı Behçet Hastalarında ve kontrol vakalarında sırasıyla % 69.3 ± 14.0 ve % 54.6± 22.0 idi (p=0.035). Tartışma: Mide yarı boşalma zamanları arasında belirgin bir farklılık olmamasına rağmen 60. dakikada midede kalan radyoaktif madde oranı Behçet Hastalarında kontrol grubuna göre belirgin yüksekti. Sonuç olarak gastrik staz Behçet Hastalarında multisistemik tutulum sonucu görülebilir.Öğe Evaluation of total antioxidant status, total oxidant status and oxidative stress index in patients with alopecia areata(E-Century Publishing Corp, 2014) Motor, Sedat; Ozturk, Sahin; Ozcan, Oguzhan; Gurpinar, Ahmet Burak; Can, Yesim; Yuksel, Rana; Yenin, Julide ZehraObjectives: In this study, we aimed to evaluate total oxidative stress and total antioxidant capacity in serum samples from patients with Alopesia Areata (AA) in our laboratory conditions. Methods: In this study, 46 subjects with AA (26 females, 20 males) and the control subjects of 36 (20 females, 16 males) age-and sex-matched healthy volunteers from our hospital staffs were enrolled (the mean age was 23.7 +/- 11.0 years). Blood samples were obtained following an overnight fasting state, and were collected on ice at 4 degrees C. The serum samples were separated from the cells by centrifugation at 3000 rpm for 15 min and were stored at -80 degrees C and used for the analysis of the Total Antioxidant Status (TAS) and Total Oxidant Status (TOS). Results: Total Antioxidant Status (TAS) and Total Oxidant Status (TOS), Oxidative Stress Index (OSI) (TOS/TAS) levels of AA patients were 1.4777 +/- 0.1986; 9.7490 +/- 6.0445; 0.6593 +/- 0.4069 respectively. TAS; TOS; OSI (TOS/TAS) levels of controls were 1.4028 +/- 0.1687; 9.4627 +/- 4.2781; 0.6875 +/- 0.3232 respectively. TAS, TOS and OSI levels showed no significant difference between the control and AA group (p > 0.05). Conclusion: Future studies about AA pathogenesis should be based not only on oxidant/antioxidant balance but also on several other factors. Because it was observed that the disease showed recurrence in different situations. Since the selection criteria of patients is affected from disease severity and environmental and genetical factors, multicentric studies with better sampled patient population and higher patient number is required.Öğe High prevalence of Staphylococcus aureus cultivation and superantigen production in patients with psoriasis(John Libbey Eurotext Ltd, 2009) Balci, Didem Didar; Duran, Nizami; Ozer, Burcin; Gunesacar, Ramazan; Onlen, Yusuf; Yenin, Julide ZehraThe aim of this study was to evaluate the association of Staphylococcal enterotoxins (se) a through e, exfoliative toxin (et) a and b, toxin and toxic shock syndrome toxin (tst) and mecA with psoriasis. We also investigated the distribution of Staphylococcus aureus (S. aureus) in the skin and nares. Fifty consecutive patients with chronic plaque-type psoriasis and 50 sex- and age-matched healthy controls were included in this study. There was a statistical difference in cultivation of S. aureus between lesional (64%) and non-lesional skin (14%) in patients with psoriasis (p = 0.037). S. aureus was cultivated from the nares in 25 (50%) of 50 patients with psoriasis and in 17 (34%) of 50 healthy controls (p > 0.05). In psoriasis patients, 31 (96.8%) out of the 32 strains isolated from the lesional skin and 3 (42.3%) out of the 7 strains isolated from the non-lesional skin were toxigenic (p = 0.01). Isolated strains from the nares were toxigenic in 96% (24/25) for patients with psoriasis and in 41.2% (7/17) for healthy controls, respectively (p = 0.006). Patients with cultivation-positive in lesional skin had a significantly higher PASI score than patients who were cultivation-negative in lesional skin (8.28 +/- 3.97 vs. 5.89 +/- 2.98, p = 0.031). Our results confirm that S. aureus colonization and its toxigenic-strains are associated with psoriasis. According to our findings, non-classical superantigens such as methicillin resistance gene (mecA), see and etb may also be associated with psoriasis.Öğe Increased Amount of Visceral Fat in Patients with Psoriasis Contributes to Metabolic Syndrome(Karger, 2010) Balci, Ali; Balci, Didem Didar; Yonden, Zafer; Korkmaz, Inan; Yenin, Julide Zehra; Celik, Ebru; Okumus, NeseBackground: Psoriasis is associated with obesity and metabolic syndrome. Metabolic syndrome is associated with visceral fat accumulation. There is no study on the accumulation of visceral fat in patients with psoriasis. Objective: The aim of this study was to compare the visceral fat accumulation in patients with psoriasis and controls. Subjects and Methods: 46 patients with psoriasis and 46 sex-and age-matched control patients were included in this study. The abdominal fat area [visceral fat area (VFA), subcutaneous fat area (SFA) and total fat area (TFA)] at the level of the umbilicus was evaluated by computed tomography. Results: The mean VFA value and VFA/SFA ratio of the psoriasis patients were significantly higher compared with the control patients (123.4 +/- 80.3 vs. 81.2 +/- 59.8 cm(2) and 0.734 +/- 0.593 vs. 0.491 +/- 0.336; p = 0.005 and p = 0.017, respectively). Fasting blood sugar levels were also found to be significantly higher in psoriasis patients, compared with the control patients (101.8 +/- 43.5 vs. 83.4 +/- 9.1 mg/dl; p = 0.005). Multiple linear regression analysis indicated that waist-to-hip ratio, age, body weight, the presence of psoriasis and metabolic syndrome were significantly associated with VFA. Conclusion: Psoriasis patients had a higher amount of VFA, compared with the control patients. Copyright (C) 2009 S. Karger AG, BaselÖğe Serum homocysteine, folic acid and vitamin B12 levels in vitiligo(John Libbey Eurotext Ltd, 2009) Balci, Didem Didar; Yonden, Zafer; Yenin, Julide Zehra; Okumus, Nese[Abstract Not Available]
