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Öğe EFFICACY AND SAFETY OF TENOFOVIR ALAFENAMIDE IN HEPATITIS B VIRUS-INFECTED PATIENTS WITH CHRONIC HEMODIALYSIS AND RENAL TRANSPLANTATION: A PRELIMINARY RESULT(Wiley, 2021) Adanir, Haydar; Etik, Digdem Ozer; Yildirim, Abdullah Emre; Mehdiyev, Shahin; Yapali, Suna; Cosar, Arif Mansur; Ari, Derya[Abstract Not Available]Öğe The efficacy and tolerability of glecaprevir/pibrentasvir treatment in a real-world chronic hepatitis C patients cohort(Kare Publ, 2023) Yaras, Serkan; Demir, Mehmet; Barutcu, Sezgin; Yildirim, Abdullah Emre; Gurel, Selim; Ucbilek, Enver; Kurtulmus, Ilkce AkgunBackground and Aim: The aims of the present study were to evaluate the real-life efficacy and tolerability of glecaprevir (GLE)/pibrentasvir (PIB) in the treatment of patients with chronic hepatitis C (CHC).Materials and Methods: Between May 2019 and May 2022, 686 patients with CHC, treated with GLE/PIB combination from 21 participating centers in Turkiye, were enrolled in the study.Results: All patients were Caucasian, and their median age was 56 years. At the start of GLE/PIB treatment, the median serum Hepatitis C virus RNA and serum alanine amino transaminase (ALT) levels were 6.74 log10 IU/mL and 47 U/L, respectively. Fifty-three percent of the patients were infected with genotype 1b, followed by genotype 3 (17%). Diabetes was the more common concomitant disease. The sustained virological response (SVR12) was 91.4% with intent-to-treat analysis and 98.5% with per protocol analysis. The SVR12 rates were statistically significant differences between the patients who were i.v. drug users and non-user (88.0% vs. 98.8%, p=0.025). From the baseline to SVR12, the serum ALT levels and Model for End-Stage Liver Disease score were significantly improved (p<0.001 and p=0.014, respectively). No severe adverse effect was observed.Conclusion: GLE/PIB is an effective and tolerable treatment in patients with CHC.Öğe Etiology of Cirrhosis in Turkey: A National Cohort Study(Elsevier, 2021) Yildirim, Abdullah Emre; Ucbilek, Enver; Oruncu, M. Berk; Turan, Ilker; Demir, Mehmet; Koksal, Aydin; Uyanikoglu, Ahmet[Abstract Not Available]Öğe Preliminary results of the effectiveness and safety of Tenofovir Alefenamide Fumarate prophylaxis in HBV-infected individuals, who received chemo/immunosuppressive therapy(Elsevier, 2022) Gunduz, Feyza; Durak, Serdar; Unsal, Yasemin; Demir, Mehmet; Ellik, Zeynep Melekoglu; Yildirim, Abdullah Emre; Mehdiyev, Shahin[Abstract Not Available]
