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Öğe Abdominal Aortic Aneurysm as a Long Time Cause of Low Back Pain and Vertebral Scalloping(Oxford Univ Press, 2016) Yildizgoren, Mustafa Turgut; Ogut, Halil; Kayali, Alperen; Turhanoglu, Ayse Dicle[Abstract Not Available]Öğe Anti-interleukin-1 treatment in 26 patients with refractory familial mediterranean fever(Springer, 2017) Kucuksahin, Orhan; Yildizgoren, Mustafa Turgut; Ilgen, Ufuk; Ates, Askin; Kinikli, Gulay; Turgay, Murat; Erten, SukranObjective: To investigate the effect of anti-interleukin-1 (anti-IL-1) treatment on the frequency and severity of attacks and other disease-related clinical parameters and to evaluate the adverse effects associated with anti-IL-1 treatment in 26 patients with refractory familial mediterranean fever (FMF).Methods: The study included 26 FMF patients followed up in our centre using colchicine for 4 months to 30 years. The treatment was switched to anti-IL-1 treatment for various reasons; 20 cases were resistant to colchicine, 8 were intolerant to colchicine, and 3 had prolonged arthritis under colchicine. Clinical response was monitored through the number of attacks, and laboratory inflammation was monitored through erythrocyte sedimentation rate, C-reactive protein, and serum amyloid A concentrations. Colchicine resistance was defined as at least two attacks/month together with C-reactive protein and serum amyloid A levels above the normal range between attacks. The colchicine dose was increased to 2mg/day before they were considered colchicine-resistant.Results: 24 patients used anakinra (100mg/day), and 2 used canakinumab (150mg/month), for -36 months. Sixteen patients with colchicine resistance had no attacks under anti-IL-1 treatment, and 4 had decreased frequency and duration of attacks. Seven of 8 patients intolerant to colchicine used anakinra, and 6 were attack-free under treatment, while 1 using canakinumab had attacks under treatment. One patient with prolonged arthritis used canakinumab but arthritis showed progression and the treatment was changed to IL-6 inhibitor. Three patients had injection site erythema and one had fatigue with anti-IL-1 treatment. Topical steroids with systemic antihistaminics were sufficient for symptom control in two cases, but canakinumab treatment was given due to severe injection site erythema in one case.Conclusion: Anti-IL-1 agents are rational treatment modalities in patients resistant or intolerant to colchicine. Anti-IL-1 agents can control FMF attacks quite effectively and they have a promising role in the treatment of FMF.Öğe Assessment of the Anterior Talofibular Ligament Thickness in Patients with Chronic Stroke: An Ultrasonographic Study(Elsevier Singapore Pte Ltd, 2017) Yildizgoren, Mustafa Turgut; Velioglu, Onur; Demetgul, Ozcan; Turhanoglu, Ayse DicleBackground: Patients with equinovarus deformity have an increased risk of fall and ankle ligament injury, because of inappropriate prepositioning of the ankle at the end of the swing phase, and inadequate leg and ankle stability during the stance phase. Accordingly, the aim of this study is to compare anterior talofibular ligament (ATFL) thickness of chronic stroke patients with that of healthy individuals using ultrasonography. Methods: This was a case-control study conducted in a university hospital between July 2015 and July 2016. We included 38 patients [study group; mean age, 59.0 +/- 11.1 years; mean body mass index (BMI), 25.4 +/- 4.3 kg/m(2)] and a control group of age-, sex-, and BMI-matched healthy individuals. Demographic and clinical characteristics of the patients (i.e., age, weight, height, Brunnstrom motor recovery stage, Functional Ambulation Scale, Ashworth Scale, and duration of hemiplegia) were recorded during their visits. Furthermore, ultrasound image of the ATFL was obtained from each ankle. The thickness of the ATFL was measured at the midpoint of the ligament between the attachments on the lateral malleolus and the talus using ultrasonography. Results: In the study group, the mean thickness of the ATFLs of the affected side (2.75 +/- 0.41 mm) was thicker than both the unaffected side (2.42 +/- 0.30 mm) and the healthy controls (2.35 +/- 0.19 mm; p = 0.007, p < 0.001, respectively). No differences were seen between the two sides of the control group. Conclusion: Chronic stroke patients have a thicker ATFL on both the affected and unaffected sides, compared with healthy individuals. This architectural feature of the ATFL may be a result of equinovarus deformity together with spastic muscles. For this reason, early treatment of deformed ligaments and spastic muscles is needed to prevent equinovarus deformity in patients with stroke. (C) 2017, Elsevier Taiwan LLC and the Chinese Taipei Society of Ultrasound in Medicine. This is an open access article under the CC BY-NC-ND license.Öğe Assessment of the Relationship between Physical Activity Levels and Isokinetic Muscle Performance(Galenos Yayincilik, 2016) Micoogullari, Ahmet; Yildizgoren, Mustafa Turgut; Turhanoglu, Ayse Dicle; Ustun, Nilgun; Guler, HayalObjective: To evaluate the association between physical activity levels and isokinetic muscle strength of knee. Materials and Methods: Thirty amateur athletes and 30 healthy volunters (aged between 20-24) were included in the study. Participants were divided into two groups as amateur athletes (group 1) and healthy controls (group 2). Physical activity levels of the participants were assessed by International Physical Activity Questionnaire (IPAQ). Dominant knee flexion and extension muscle strength of the participants were measured with an isokinetic dynamometer at 60 degrees/s and 180 degrees/s angular velocities. Results: There were no statistically significant difference between the groups in age, sex, weight, height, body mass index and, smoking status (p>0.05). There was a statistically significant difference in IPA scores between the groups (p<0.05). IPAQ scores were higher in group1I. There were no statistically significant difference between the knee extensor and flexor peak torque values in both groups (p>0.05). Group 1 was divided into subgroups according to IPA scores. In patients with high activity level, peak torque values at the angular velocities of 60 degrees/s and 180 degrees/s for knee muscles were significiantly higher (p<0.05). Conclusion: Further studies that evaluating of the many factors that determining and affecting muscle strength are with larger groups will be beneficial.Öğe Association of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional study(Springer London Ltd, 2016) Oguz, Ekin Oktay; Kucuksahin, Orhan; Turgay, Murat; Yildizgoren, Mustafa Turgut; Ates, Askin; Demir, Nalan; Kumbasar, Ozlem OzdemirIt was aimed to evaluate KL-6 glycoprotein levels to determine if it may be a diagnostic marker for the connective tissue diseases (CTDs) predicting CTD-related interstitial lung diseases (ILDs) (CTD-ILD) development and to examine if there was a difference between patients and healthy controls. The study included 113 patients with CTD (45 CTD without lung involvement, 68 CTD-ILD) and 45 healthy control subjects. KL-6 glycoprotein levels were analyzed with ELISA in patients and the control group. The relationship between KL-6 glycoprotein levels and CTD-ILD was assessed. In the comparison of all the groups in the study, significantly higher levels of KL-6 were determined in the CTD-ILD group than in either the CTD without pulmonary involvement group or the healthy control group (p < 0.008 and p < 0.001, respectively). There was no statistically significant difference between the KL-6 levels in the healthy control group and the CTD without pulmonary involvement group (p = 0.289). The KL-6 levels did not differ significantly according to the connective tissue diseases in the diagnostic groups (systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, mixed connective tissue disease, scleroderma, polymyositis/ dermatomyositis). In the healthy control group, there was a statistically significant difference between KL-6 levels in smokers and non-smokers. Smokers had significantly higher serum KL-6 levels compared with non-smokers (p < 0.05). There was no statistically significant difference between smoking status (pack-year) and serum KL-6 levels. There was no statistically significant correlation between serum KL-6 levels and time since diagnosis of CTD and CTD-ILD. The level of KL-6 as a predictive factor could be used to identify the clinical development of ILD before it is detected on imaging modality. Further prospective clinical studies are needed to define whether levels of KL-6 might have prognostic value or might predict progressive ILD.Öğe Bosentan For Digital Ulcers in Patients With Systemic Sclerosis: Single Center Experience(Turkish League Against Rheumatism, 2016) Kucuksahin, Orhan; Yildizgoren, Mustafa Turgut; Gerede, Demet Menekse; Maras, Yuksel; Erten, SukranObjectives: This study aims to investigate the effects of bosentan on the prevention and treatment of digital ulcers in systemic sclerosis (SSc) patients. Patients and methods: The study included 30 patients (4 males, 26 females; mean age 49.6 +/- 15.4 years; range 23 to 71 years) diagnosed with SSc and treated with bosentan for digital ulcers. Bosentan was administered to all patients for a mean of 14 +/- 10.3 months. All SSc cases were refractory to calcium channel antagonists or angiotensin II inhibitors. The diagnosis of SSc was based on the American College of Rheumatology criteria and patients were classified as limited or diffuse cutaneous SSc according to the LeRoy classification. Results: Mean disease duration was 8.8 +/- 8.0 years and mean duration of digital ulcers was 29.4 +/- 6.6 months. Under the bosentan treatment, eight patients (26.7%) developed new digital ulcers; all of these patients had diffuse cutaneous SSc. Health Assessment Questionnaire scores improved after 12 months and 24 months of treatment (p<0.001). Three patients (10%) developed pulmonary arterial hypertension under bosentan treatment [ two patients (6.6%) had SSc-associated pulmonary arterial hypertension and one patient (3.3%) had interstitial fibrosis-associated pulmonary arterial hypertension]. The anti-centromere antibody positive patients were predominantly classified as limited cutaneous SSc. Of the patients positive for anti-topoisomerase-1 antibodies, a high proportion was classified as diffuse cutaneous SSc. Pulmonary fibrosis was most frequent in the anti-topoisomerase-1 antibody subset. New digital ulcers developed mainly in the anti-topoisomerase-1 antibody positive patients. Conclusion: Bosentan may be used either alone or in combination with other treatments when digital ulcers worsen and may be expected to suppress the development of new ulcers and severe pain. Further preclinical studies are required shedding light on the etiopathogenesis of SSc and larger clinical trials are needed for more definitive treatment strategies.Öğe Can systemic involvements, therapeutic approaches, and sociodemographic features of individuals be associated with depression in rheumatic diseases?(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2016) Ekiz, Timur; Yildizgoren, Mustafa Turgut[Abstract Not Available]Öğe A case with essential tremor refractory to medication successfully treated with deep brain stimulation(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2018) Yilmaz, Atilla; Yildizgoren, Mustafa Turgut; Okuyucu, Emine Esra[Abstract Not Available]Öğe Clinical and Demographic Characteristics of Patients Who Were Treated with Kyphoplasty Due to Osteoporotic Fracture(Galenos Yayincilik, 2017) Yilmaz, Atilla; Yildizgoren, Mustafa Turgut; Oral, Sukru; Serarslan, YurdalObjective: The aim of this study is to determine the demographic and clinical characteristics of patients who underwent kyphoplasty due to osteoporotic fractures. Materials and Methods: This retrospective study included 55 patients who underwent kyphoplasty due to osteoporotic fracture between the years 2011 and 2014. The patients divided into two groups according to their ages (under/over 65 years), and divided into three groups according to fracture regions (T10 and above; between T11-L1; L2 and under). Thus the age and gender distributions of the patients were made. Resting pain scores of all patients were determined by using visual analog scale (VAS) and daily life activities by Oswetry Disability Index (ODI) before and in the first month of treatment. Results: Seventeen of the all patients were male (30.9%) and 38 were female (69.1%), with a mean age of 69.9 +/- 8.7 years (between 50-88 ages). 90% of the patients older than 65 years had fracture in T11 and below. In 45.5% of all patients, the fracture was in the T11-L1 (thoracolomber junction) region. Resting VAS and ODI scores significantly improved from 8.7 +/- 1.5 to 2.1 +/- 1.2 and 44.7 +/- 7.2 to 15.4 +/- 3.5 respectively in the first month after kyphoplasty (p<0.05). Kyphoplasty material extravasated to the disc space in 7 (12.7%) patients and in 4 (7.3%) patients to cerebrospinal fluid. Conclusion: Osteoporotic fractures affect patients over 65 years of age and are frequently occur in the thoracolumbar junction and lower vertebras. Kyphoplasty is a minimally invasive treatment option to relieve pain and to improve functional status.Öğe Conservative Treatment of Achilles Tendinosis, and Importance of Ultrasonography in The Follow-Up: A Case Report(Galenos Yayincilik, 2015) Yildizgoren, Mustafa Turgut; Osmanoglu, Kasim; Ustun, Nilgun; Guler, Hayal; Turhanoglu, Ayse DicleAchilles tendinopathy is a painful condition that often develops as a result of overloading to tendon. There are many factors in etiology like tendon ischemia, micro-tears and metabolic events. Non-insertional tendon region of the Achilles tendon that has poor vascularity is a common localization for tendinopathy. In this paper, we presented a 55 year old man, who had pain and swelling in the right heel and we discussed the importance of ultrasound.Öğe Destructive invasion of the clavicle by desmoid tumor: a case report(African Field Epidemiology Network-Afenet, 2014) Togral, Guray; Yildizgoren, Mustafa Turgut; Arikan, Murat; Gungor, SafakDesmoid tumors are rare, soft-tissue neoplasms that do not metastasize, but exhibit aggressive growth and local invasion. They originate most frequently from abdominal fascial structures, although they can also appear at extra-abdominal sites. The most common extra-abdominal locations include the shoulder, chest wall, back, thigh, and head and neck. In children, desmoid tumors are more infiltrative, having a tendency towards osseous involvement more frequently than in adult patients. We report acase of a supraspinatus muscle desmoid tumor in a female patient with clavicle destruction.Öğe The Effect of Anti-Tumor Necrosis Factor-Alpha Treatment on Muscle Performance and Endurance in Patients With Ankylosing Spondylitis: A Prospective Follow-Up Study(Turkish League Against Rheumatism, 2017) Demirkapi, Musa; Yildizgoren, Mustafa Turgut; Guler, Hayal; Turhanoglu, Ayse DicleObjectives: This study aims to evaluate muscle performance by using isokinetic dynamometer before and at third month of anti-tumor necrosis factor-alpha treatment in ankylosing spondylitis patients. Patients and methods: Thirty ankylosing spondylitis patients (23 males, 7 females; mean age 39.3 +/- 8.6 years; range 18 to 45 years) starting on antitumor necrosis factor-alpha treatment and 30 healthy controls (23 males, 7 females; mean age 39.1 +/- 8.8 years; range 18 to 48 years) with similar age, body mass index, and sex were enrolled. The clinical anthropometric measurements of chest expansion, lumbar Schober test, hand-finger floor distance and visual analog scale-global, C-reactive protein, erythrocyte sedimentation rate, Ankylosing Spondylitis Disease Activity Score-C-reactive protein and Ankylosing Spondylitis Disease Activity Score-erythrocyte sedimentation rate, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Metrology Index, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Metrology Index were determined before and at third month of the treatment. Results: There was no statistically significant difference in age, sex and, body mass index between the groups (p>0.05). A statistically significant difference was detected between 60 degrees/second and 180 degrees/second peak torque in angular velocity of flexor and extensor muscles (p<0.05). A significant difference was detected in respect to total work of patients with 180 degrees/second peak torque in angular velocity of flexor and extensor muscles (p<0.05). There was a statistically significant difference between the findings of 60 degrees/second and 180 degrees/second peak torque in angular velocity of flexor and extensor muscles (p<0.05). Isokinetic test results were better at third month after treatment than before treatment. Conclusion: The results of this study showed that both functional limitations and performance and endurance of muscles may be improved with anti-tumor necrosis factor-alpha treatment in ankylosing spondylitis patients.Öğe The effect of subthalamic nucleus - Deep brain stimulation and different stimulation frequencies on cerebral hemodynamics in Parkinson's disease: A transcranial doppler study(Elsevier, 2020) Koban, Orkun; Yildizgoren, Mustafa Turgut; Aras, Mustafa; Oral, Sukru; Uyanik, Sadik Ahmet; Serarslan, Yurdal; Okuyucu, Esra EmineObjectives: To investigate the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) and to compare low-frequency versus high-frequency STN-DBS on hemodynamic parameters of the middle cerebral artery between patients with advanced Parkinson's disease and age-sex matched healthy controls. Patients and Methods: Eighteen patients with advanced Parkinson's disease (PD) with bilateral STN-DBS and 18 control subjects underwent Transcranial Doppler Ultrasound (TCDU) were included in the study. The hemodynamic parameters including blood flow velocity (FV), pulsatility index (PI) and, resistance index (RI) of the right middle cerebral artery (MCA) were measured and compared during the phases using TCDU. The first DBS-off, the second low-frequency DBS of 60 Hz, and the third high-frequency DBS of 130 Hz were compared. Results: PD patients had significantly higher MCA-PI values compared with controls (0.99 +/- 0.27 vs. 0.82 +/- 0.14) (p = 0.031). Also, the MCA-PI values were higher in the low-frequency DBS (0.94 +/- 0.14) and high-frequency DBS (0.93 +/- 0.16) than in the controls (0.82 +/- 0.14) (p = 0.022 and p = 0.041, respectively). There were no significant differences of FV and RI values among the DBS-on, DBS-off and, controls. The RI values were higher in the PD patients than in the controls, although these were not statistically significant. Also, PI values of the MCA decrease in different frequencies (60 Hz or 130 Hz). Conclusion: The results of this study showed that MCA-PI values are higher in advanced PD compared with controls. These indices indicate that MCA resistances and impedances are increased in advanced PD. Low- or high-frequency DBS treatment have beneficial effect to reduce high PI in advanced PD patients.Öğe Effectiveness of Ozone Therapy on Tendon Healing: An Experimental Study in Generated Achilles Tendon Injury Model in Rats(Journal Hard Tissue Biology, 2018) Kizilkaya, Volkan; Uruc, Vedat; Levnet, All; Kanat, Ozgur; Yildizgoren, Mustafa Turgut; Dogramaci, Yunus; Kalacı, AydınerThe aim of this experimental study was to investigate the effects of ozone therapy on tendon healing in rats. A total of 60 adult male, 1-year old Wistar albino rats weighing 450-500 g were randomly assigned to the ozone group (Group 1, n:30) or the control group (Group 2, n:30). In both groups, the right and left Achilles tendons were cut transversally and then sutured. Group 1 underwent ozone treatment rectally (40 mu g/mL) four times a week, while Group 2 received only nutrition and routine care. Ten rats from each group were sacrificed and evaluated in respect of histopathological and biomechanical properties at the end of the 2nd, 4th and 6th weeks. There were statistically significant differences between the groups in respect of fibroblastic proliferation (p=0.042) and inflammation (p=0.001) in the 2nd week. Fibroblastic proliferation was higher in the ozone group, and inflammation in the control group was found to be higher. Remodeling and fibroblastic proliferation were significantly increased in the ozone group in the 4th week (p = 0.007 and p=0.003, respestively). In the 6th week, high remodeling and high fibroblast proliferation were observed in the ozone group compared with the control group (p=0.020, p=0.004, respectively). The biomechanical results revealed that the ozone group had significantly higher breaking load and breaking tensile stress values than the control group in the 6th week (p = 0.007, p = 0.003, respectively). The histopathological and biomechanical findings indicated that the ozone therapy had beneficial effects on Achilles tendon rupture healing.Öğe Effects of radial extracorporeal shock wave therapy on clinical variables and isokinetic performance in patients with knee osteoarthritis: a prospective, randomized, single-blind and controlled trial(Springer, 2020) Uysal, Alper; Yildizgoren, Mustafa Turgut; Guler, Hayal; Turhanoglu, Ayse DicleObjective This study aims to compare the efficacy of r-ESWT treatment with sham-ESWT on pain, walking speed, physical function, and isokinetic muscle strength in knee osteoarthritis. Methods The study included 104 patients (mean age 61.0 +/- 6.2 years; range 50 to 70 years) who were admitted to our outpatient clinic with newly diagnosed with knee osteoarthritis. Patients were randomly assigned to two groups. Both groups received transcutaneous electrical nerve stimulation for 30 minutes, hot pack for 40 minutes, and home-based exercise program of around the knee strengthening for 30 minutes in a day for three weeks (5 days in a week). Also, one group was treated with r-ESWT, while the other group was treated with sham-ESWT. For r-ESWT, patients received 2000 pulses of shockwave at 2.0 to 3.0 bar weekly for three weeks. All patients were evaluated with visual analog scale (VAS), active knee range of motion (ROM), 20-metre walk test, Western Ontario and McMaster Osteoarthritis Index (WOMAC), Lequesne's disability index, and isokinetic muscle performance before treatment, at the end of treatment, at one month and three months after treatment. Results When groups were compared, group 1 scores were significantly better than the group 2 in all outcome parameters except WOMAC-stiffness at the end of treatment, at one month and three month follow-up (all p < 0.05). The VAS-resting, VAS-movement, knee ROM, 20-m walk test, WOMAC, and Lequesne's disability scores and peak torque values of knee extension improved in both groups with the highest improvement in the r-ESWT group. A comparison of difference of the two group scores showed statistically significant superior improvement in group 1 in all parameters at both one month and three months. Conclusion Our findings revealed that r-ESWT combined with conventional electrotherapy is an effective treatment for improving pain and physical function in knee osteoarthritis to control symptoms up to three months.Öğe Idiopathic Presentation of Remitting Seronegative Symmetrical Synovitis with Pitting Edema in an Older Man(Wiley-Blackwell, 2015) Yildizgoren, Mustafa Turgut; Sahin, Ali; Osmanoglu, Kasim; Velioglu, Onur[Abstract Not Available]Öğe Investigating the effect of STN-DBS stimulation and different frequency settings on the acoustic-articulatory features of vowels(Springer-Verlag Italia Srl, 2018) Yilmaz, Atilla; Sarac, Elif Tugba; Aydinli, Fatma Esen; Yildizgoren, Mustafa Turgut; Okuyucu, Emine Esra; Serarslan, YurdalIntroduction Parkinson's disease (PD) is the second most frequent progressive neuro-degenerative disorder. In addition to motor symptoms, nonmotor symptoms and voice and speech disorders can also develop in 90% of PD patients. The aim of our study was to investigate the effects of DBS and different DBS frequencies on speech acoustics of vowels in PD patients. Methods The study included 16 patients who underwent STN-DBS surgery due to PD. The voice recordings for the vowels including [a], [e], [i], and [o] were performed at frequencies including 230, 130, 90, and 60 Hz and off-stimulation. The voice recordings were gathered and evaluated by the Praat software, and the effects on the first (F1), second (F2), and third formant (F3) frequencies were analyzed. Results A significant difference was found for the F1 value of the vowel [a] at 130 Hz compared to off-stimulation. However, no significant difference was found between the three formant frequencies with regard to the stimulation frequencies and off-stimulation. In addition, though not statistically significant, stimulation at 60 and 230 Hz led to several differences in the formant frequencies of other three vowels. Conclusion Our results indicated that STN-DBS stimulation at 130 Hz had a significant positive effect on articulation of [a] compared to off-stimulation. Although there is not any statistical significant stimulation at 60 and 230 Hz may also have an effect on the articulation of [e], [i], and [o] but this effect needs to be investigated in future studies with higher numbers of participants.Öğe Investigating the effects of subthalamic Nucleus-Deep brain stimulation on the voice quality(Taylor & Francis Ltd, 2020) Sarac, Elif Tugba; Yilmaz, Atilla; Aydinli, Fatma Esen; Yildizgoren, Mustafa Turgut; Okuyucu, Emine Esra; Okuyucua, Semsettin; Akakin, AkinIntroduction: Deep brain stimulation (DBS) is a standard surgical treatment method which is generally applied to subthalamic nucleus in Parkinson's patients in cases where medical treatment is insufficient in treating the motor symptoms. It is known that Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) treats many motor symptoms. However, the results of studies on speech and voice vary. The aim of the study is analysing the effect of STN-DBS on the characteristics of voice. Materials/methods: A total of 12 patients, (8 male-4 female) with an age average of 58.8 +/- 9.6, who have been applied DBS surgery on STN included in the study. The voice recordings of the patients have been done prior to surgery and 6 months after the surgery. The evaluation of voice has been carried out through the instrumental method. The patients' voice recordings of the /a,e,i/ vowels have been done. The obtained recordings were evaluated by the Praat programme and the effects on jhitter, shimmer, fundamental frequency (F0) and noise harmonic rate (NHR) were analysed. Results: Numerical values of F0 of all female participants have been decreased for all of the vowels postoperatively. In the females; jhitter and fraction parameters were found to be significantly different (0.056 and 0.017, perspectively) for the vowel /e/. In addition, p values in the shimmer for vowels /e,i/ were thought to be clinically significant (.087, .079 and .076) respectively. All these changes in second measurements were found to indicate worsening vocal quality after the DBS in females. In males, there is not any significant difference observed between two measures in any of the parameters of any vowels. Conclusions: Acoustic voice quality deteriorated after STN-DBS predominantly for females however this deterioration was not prominent audio-perceptually. This finding commented as a result of the fact that that voice quality deviance of the participants was not severe.Öğe Isotretinoin treatment in patients with acne vulgaris: Does it impact muscle strength, fatigue, and endurance?(Quadrant Healthcom Inc., 2015) Yildizgoren, Mustafa Turgut; Rifaioglu, Emine Nur; Demirkapi, Musa; Ekiz, Timur; Micoogullari, Ahmet; Sen, Tugba; Turhanoglu, Ayse DicleThe objective of this study was to evaluate the effects of isotretinoin on muscle strength, fatigue, and endurance in patients with acne vulgaris. The study included 27 patients with acne vulgaris who underwent treatment with isotretinoin as well as 26 control patients for comparison. Participants in the treatment group received oral isotretinoin 0.5 mg/kg once daily for 1 month followed by an increased dose of 1 mg/kg once daily for 2 months. Isokinetic measurements were obtained from the hamstrings and quadriceps on the nondominant side of the body at baseline and 3-month follow-up using an isokinetic dynamometer. Results indicated that systemic isotretinoin did not significantly alter muscle strength, fatigue, and endurance.Öğe The medium-term effects of diadynamic currents in chronic low back pain; TENS versus diadynamic currents: A randomised, follow-up study(Elsevier Sci Ltd, 2017) Sayilir, Selcuk; Yildizgoren, Mustafa TurgutObjective: The aims of the study were to evaluate the medium-term effects of diadynamic (DD) currents on relieving symptoms/improving physical functionality in patients with chronic low back pain (LBP) and to compare the efficacy of DD versus TENS. Methods: The patients were divided into two groups as the TENS group (n = 26) and the DD group (n = 29). Additional treatment of hot pack + therapeutic ultrasound was applied to all patients. The therapy programs were administered as a total of 10 sessions over a period of 2 weeks. Roland Morris Disability Questionnaire (RDQ), Oswestry Disability Index and Visual Analog Scale (VAS) values were recorded. Results: Both groups showed significant improvements in VAS and RDQ scores after one month of the therapies (all p < 0.05). Conclusion: Using TENS and DD currents in chronic LBP can lead to reduced pain, and improved physical functions. Hence, DD currents can be used as an adjuvant therapy for rehabilitation of chronic LBP. (C) 2017 Elsevier Ltd. All rights reserved.
