Yazar "Yilmaz, Ş." seçeneğine göre listele

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  • Küçük Resim
    Öğe
    Investigation of liposome formulation effects on rivastigmine transport through human colonic adenocarcinoma cell line (CACO-2)
    (2010) De?im, Z.; Mutlu, N.B.; Yilmaz, Ş.; Eşsiz, D.; Nacar, A.
    Transportations of rivastigmine containing liposomes across Caco-2 cells were studied and in vitro test results were compared with in vivo results. MTT test was used for cell viability studies. Series of formulations were prepared containing rivastigmine which is used for the treatment of Alzheimer's disease. Characterization and stability studies for liposome formulations were performed. Encapsulation efficiencies of liposomes were 35.4%, 25.2% and 29.9% for rivastigmine, rivastigmine-sodium taurocholate, rivastigmine-dimethylbeta-CD liposomes, respectively. In stability studies, particle size and size distribution, zeta potential, rivastigmine amounts were determined and shelf lives of liposomes were calculated. Penetration properties of rivastigmine through Caco-2 cells, dialysis membrane and kinetics of release from liposomes were determined. Permeability coefficients were calculated after diffusion studies. The highest value of % cumulative amount of rivastigmine passed through caco-2 cell cultures was found to be 87.2% for rivastigmine-sodium taurocholate solution and 12.8% for rivastigmine-sodium taurocholate liposome. The highest permeability coefficient value was obtained with sodium taurocholate liposomes for -0.75. Rivastigmine liposomes and solutions were also applied to animals. Acetyl choline esterase (AChE) activity was determined by the Ellman method on mice. %AChE inhibition values were calculated using blood and brain tissue samples. The physical appearances of the brains were investigated by TEM microscope. The highest value of AChE inhibition was observed for rivastigmine and sodium taurocholate liposomes. The histological investigations and observations also supported these results.
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    Öğe
    Nitrogen and plant density effects on sorghum
    (2008) Guler, Mustafa; Gül, I.; Yilmaz, Ş.; Emeklier, H.Y.; Akdo?an, G.
    The aim of this study was to evaluate the effect of nitrogen and plant density on some morphological and agronomic characteristics of grain sorghum in the years 2001-2002. Experimental design was a split-split, randomized complete block with three replications. Three nitrogen levels (0, 75 and 150 kg ha -1) and plant densities (70x10, 70x20 and 70x30 cm) were applied in three grain sorghum cultivars. Generally, nitrogen and plant density had no effect on plant height and stalk length. The effect of nitrogen on grain yield per plant was usually non-significant and increased plant densities tended to increase grain yield per plant. Both nitrogen and plant density have positively affected grain yield per unit area. The effects of cultivar, nitrogen level and plant density on flag leaf area were changeable and dependent on both years and locations. One thousand grain weight was mainly determined by both cultivar and plant density. It may be concluded that increased nitrogen and plant density levels generally give the best results in grain yield and yield components in sorghum. © 2008 Asian Network for Scientific Information.