Yazar "Yilmaz, B." seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats(Wiley, 2010) Aydin, M.; Oktar, S.; Yonden, Z.; Ozturk, O. H.; Yilmaz, B.Kisspeptin is a recently discovered hypothalamic peptide which plays an important role in the central control of reproductive functions We have investigated direct and indirect effects of kisspeptin on the liver oxidative stress in young male rats Twenty-four rats were divided into four groups (n = 6/group) First group served as control and received saline. Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days Rats were given only one dose gosereline (0 9 mg/rat), a GnRH agonist in the third group The last group received kisspeptin-10 with gosereline. The activities of catalase, superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (AD) and level of malondialdehyde were studied in liver tissue Serum samples were separated for total antioxidant capacity (TAC), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, blood urea nitrogen (BUN), colesterol, lipoprotein (HDL) and triglyceride. Kisspeptin increased the activities of SOD and catalase (p < 0 05) When compared to the control group. the levels of malondialdehyde. TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05) In conclusion, our findings suggest that kisspeptin may have antioxidant and thus protective effects on the liver tissue Copyright (C) 2010 John Wiley & Sons, LtdÖğe Effects of letrozole on biochemical markers of bone and liver(Amer Assoc Clinical Chemistry, 2008) Yonden, Z.; Aydin, M.; Alcin, E.; Yilmaz, B.[Abstract Not Available]Öğe Effects of letrozole on bone biomarkers and femur fracture in female rats(Servicio Publicaciones Universidad Navarra, 2009) Yonden, Z.; Aydin, M.; Alcin, E.; Kelestemur, M. H.; Kutlu, S.; Yilmaz, B.Z. YONDEN, M. AYDIN, E. ALCIN, M.H. KELESTEMUR, S. KUTLU and B. YILMAZ. Effects of letrozole on bone biomarkers and femur fracture in female rats. J Physiol Biochem, 65 (3), 267-276, 2009. We aimed to investigate the effects of the aromatase inhibitor letrozole on femur fracture and serum levels of alkaline phosphatase (ALP), calcium and phosphate in female rats. Intact 32 Sprague-Dawley female rats were divided into four groups (n=8): control, letrozole 0.2, letrozole 1 (treatment of 0.2 and 1 mg/kg for six weeks) and recovery (letrozole-treated 1 mg/kg for six weeks then allowed to recover for two weeks). Besides, 24 ovariectomized rats were divided into three groups (n=8): ovariectomized+control, ovariectomized+letrozole and ovariectomized+letrozole+ estradiol (10 mu g/rat). After experimental period, rats' femur bones were removed for biomechanical studies following decapitation. Serum ALP, calcium and phosphate were measured. Biomechanical values, ALP and phosphate significantly increased by letrozole in a dose-dependent manner (p<0.05) while calcium levels and net bone area decreased (p<0.05). Ultimate strength was positively correlated with ALP and phosphate and negatively correlated with calcium. The results indicate that letrozole may increase risk of bone fracture and affect bone biomarkers such as ALP, calcium and phosphate in both intact and ovariectomized rats.Öğe Evaluation of estrogenic effects of polychlorinated biphenyls and organochlorinated pesticides using immature rat uterotrophic assay(Sage Publications Ltd, 2013) Uslu, U.; Sandal, S.; Cumbul, A.; Yildiz, S.; Aydin, M.; Yilmaz, B.In this study, we investigated the effects of polychlorinated biphenyls (PCBs) and organochlorinated pesticides on the serum levels of luteinising hormone (LH), follicle stimulating hormone (FSH) and weights and histomorphometry of uterine tissue in immature female rats using uterotrophic assay. A total of 36 rats were randomly divided into six groups (n = 6 per group) as control, oestradiol (E-2, 100 mu g/kg), PCB 180, Aroclor 1221, endosulfan and mirex at 10 mg/kg dosage. After 3 days of injections (subcutaneous), animals were decapitated and blood samples were collected. Uteri were dissected, weighed out and then fixed in 10% formaldehyde. They were processed for histomorphometry. The serum levels of LH and FSH were determined by enzyme immunoassay. Uterine weight was significantly increased by E-2 and reduced by mirex (p < 0.001 and p < 0.05, respectively). Total volume of uterus was significantly raised by E-2, Aroclor 1221 and endosulfan compared with that of the control group (p < 0.01). The ratio of epithelium was significantly increased by E-2, PCBs and pesticides (p < 0.01). The uterine cavity ratio was decreased by aroclor (p < 0.01), PCB 180 and mirex (p < 0.05). The serum levels of LH did not significantly differ among the groups but the levels of FSH were decreased by PCB 180 and endosulfan (p < 0.05 and p < 0.01, respectively). These findings suggest that PCB 180, Aroclor 1221 and endosulfan may be estrogenic in immature uterotrophic assay.Öğe ROOTSTOCK INFLUENCES ON SEASONAL CHANGES IN LEAF PHYSIOLOGY AND FRUIT QUALITY OF RIO RED GRAPEFRUIT VARIETY(Corvinus Univ Budapest, 2018) Yilmaz, B.; Cimen, B.; Incesu, M.; Kamiloglu, Uysal M.; Yesiloglu, T.Citrus is a conventionally produced fruit crop in extensive agricultural areas in Mediterranean-type agroecosystems. The use of rootstocks for citrus fruits is necessary for profitable production under some limiting factors, such as climactic factors, bad soil conditions, and diseases. In addition, the use of the citrus rootstocks provides a large number of choices to growers to increase fruit quality and yield, obtain early fruiting, uniform cropping and high-density planting, avoid juvenility, and control tree size. The aim of the present study was to evaluate the effects of several citrus rootstocks on the fruit yield, quality, physiological changes in leaves and leaf mineral composition of Rio Red grapefruit. Thus, seasonal changes in the leaf chlorophyll concentration, PSII efficiency (Fv / Fm), stomatal conductance (gS), leaf temperature, leaf mineral nutrient, fruit yield and fruit quality traits of the Rio Red grapefruit variety grafted onto six commonly used rootstocks (Carrizo citrange, citremon, sour orange, Swingle citrumelo, Troyer citrange and Volkameriana) in citriculture were evaluated. The physiological responses of fully expanded young leaves to rootstocks were significantly affected by seasonal changes. Two-way ANOVA indicated significant main effects of rootstock and season and their interaction (p <= 0.05) on the leaf Chl concentration. Leaf Chl concentrations were lowest in April for all rootstocks. The PSII efficiency slightly decreased in the leaves of Rio Red grafted onto Volkameriana in February. The rootstocks significantly affected seasonal changes in the leaf stomatal conductance. The highest gS was recorded in October in the leaves of a Rio Red variety grafted onto the Volkameriana rootstock. Significant rootstock effects on leaf Ca, Mg, Mn, Zn and Cu concentrations were observed in the Rio Red variety. The highest leaf Zn concentration (ppm) was recorded in plants on Volkameriana, whereas the lowest Zn concentrations were recorded in plants on Troyer citrange. There were no significant rootstock effects on leaf N, P, K and Fe concentrations. The rootstocks significantly affected the fruit yield of the Rio Red variety in the 2013 and 2014 harvest years. The highest fruit yield was observed in Rio Red grafted onto Carrizo citrange in 2013, whereas it was highest in plants on Troyer citrange in 2014. The fruit weight (g), fruit diameter (mm), total soluble solids (%), juice content (%) and juice color (hue degrees) of Rio Red grapefruit were significantly affected by the rootstocks.
