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Öğe ARACHNOID CYST CAUSING SUBFALCINE HERNIATION IN A CHILD FAILURE TO THRIVE(Nobel Ilac, 2011) Dogan, Murat; Yilmaz, Cahide; Ustyol, Lokman; Caksen, HuseyinArachnoid cysts represent only 1% in all intracranial masses. The signal and density of arachnoid cysts are mostly the same as cerebrospinal fluid unless be complicated. They do not have calcification and do not retain contrast material but they are benign lesions. Although they can be seen in all ages, they are mostly detected in children. Male-female ratio is In this case report., 18 months-old-boy with subfalcine herniation because of an arachnoid cyst who was brought to our hospital only with complaint of failure to thrive was presented due to its atypical and rare presentation.Öğe Arachnoid cyst causing subfalcine herniation in a child failure to thrive(2011) Do?an, Murat; Yilmaz, Cahide; Üstyol, Lokman; Çaksen, HüseyinArachnoid cysts represent only 1% in all intracranial masses. The signal and density of arachnoid cysts are mostly the same as cerebrospinal fluid unless be complicated. They do not have calcification and do not retain contrast material but they are benign lesions. Although they can be seen in all ages, they are mostly detected in children. Male-female ratio is 3:1. In this case report, 18 months-old-boy with subfalcine herniation because of an arachnoid cyst who was brought to our hospital only with complaint of failure to thrive was presented due to its atypical and rare presentation.Öğe Assessment of nutritional status: Triceps and subscapular skin-fold thickness in Turkish children and adolescent(Professional Medical Publications, 2011) Yuca, Sevil Ari; Cesur, Yasar; Yilmaz, Cahide; Mazicioglu, Mumtaz; Kurtoglu, SelimObjectives: To determine the mean and percentile values and constitute the percentile curves of the triceps and subscapular skin-fold thickness (SFT) for obtaining a measure to be used in evaluating nutritional status of children and adolescents for age and gender to determine the threat of adiposity in Turkish children. Methodology: This cross-sectional study was carried out between October 2006 and May 2007 with 6917 students selected among those with pre-defined socio-economic criteria and attending primary schools in Van city center. Based on these data, the subjects were distributed to age groups in 6-month intervals, beginning from the age of 7 up to the age of 17. Results: Analysis of mean values of the thickness of triceps and subscapular SFT according to age in boy subjects demonstrated that these values generally increased with age up to thirteen years of age where peak values were observed, and the thickness decreased between 14 and 15 years of age, increasing again thereafter. A comparison of our data with the data reported from other countries revealed lower than median values of triceps and subscapular SFT in our study for both girls and boys regardless of the age group. Conclusions: Subcutaneous fat accumulation is lower in Turkish children compared to those in other countries and no risk of obesity is imminent, at least in the region where this study was carried out.Öğe Bilateral Abducens Paralysis Secondary to Compression of Abducens Nerve Roots by Vertebrobasilar Dolichoectasia(Informa Healthcare, 2013) Tuzcu, Esra Ayhan; Bayarogullari, Hanifi; Coskun, Mesut; Yilmaz, Cahide; Ilhan, Nilufer; Daglioglu, Mutlu Cihan; Aras, MustafaVertebrobasilar dolichoectasia is characterized by dilatation, tortuosity, and marked elongation of the vertebral and basilar arteries. Dolichoectatic arteries usually have thin arterial walls secondary to degeneration of the internal elastic lamina, reticular fibre deficiency, and smooth muscle atrophy. This anomaly is relatively uncommon and generally asymptomatic. Clinical manifestations of dolichoectasia result from the compression and displacement of adjacent structures, causing cranial nerve palsy, obstructive hydrocephalus, or ischaemic stroke. The authors present a case in which vertebrobasilar dolichoectasia led to the development of bilateral abducens nerve paralysis in a 9-year-old girl.Öğe Chronic mercury poisoning: Report of two siblings(2010) Yilmaz, Cahide; Okur, Mesut; Geylani, Hadi; Caksen, Huseyin; Tuncer, Oguz; Ataş, BulentMercury exists as organic inorganic and elementary forms in nature and is one of the most toxic metals that are poisonous for human beings. Mercury is commonly used in many different sectors of industry such as in insects formulas, agriculture products, lamps, batteries, paper, dyes, electrical/electronic devices, jewelry, and in dentistry. In this study, two siblings (one a 7-year-old boy and the other a 13 years old girl) are reported who developed chronic mercury poisoning as a result of long-term contact with batteries. Our aim is to emphasize the importance of mercury poisoning that is extremely rarely seen in childhood.Öğe Clinical Outcome and Magnetic Resonance Imaging Findings in Infants With Hypoglycemia(Sage Publications Inc, 2011) Caksen, Huseyin; Guven, Ahmet Sami; Yilmaz, Cahide; Unal, Ozkan; Basaranoglu, Murat; Sal, Ertan; Kaya, AvniThe authors examined clinical outcome and cranial magnetic resonance imaging (MRI) findings in infants with hypoglycemia to determine the effects of hypoglycemia on the developing brain. A total of 110 infants with hypoglycemia were included in the study. Of the patients, 36 were females and 74 were males. The age of the infants was between 1 day and 22 months. Of the 110 infants, 47 were preterm neonates, 40 were term neonates, and 23 were older than 28 days. No difference in serum glucose level was noted between symptomatic and asymptomatic infants. The most common observed abnormal findings were hyperintense lesions, encephalomalacia, and cerebral atrophy. Abnormal MRI findings were found in 4% of preterm infants, in 32.5% of term infants, and in 43.5% of older infants. Abnormal MRI findings were statistically significantly more common in symptomatic infants than in asymptomatic infants. Of the infants, 45.5% of hypoglycemic infants had cerebral palsy and/or cerebral palsy plus epilepsy.Öğe Congenital hypothyroidism with isolated fibula agenesis(2010) Do?an, Murat; Yilmaz, Cahide; Çaksen, Hüseyin; Cesur, Yaşar; Akpinar, Fuat; Güven, Ahmet SamiAlthough congenital hypothyroidism is seen often as an isolated case, it can also be seen as a part of some syndromes like Schinzel-Giedion, Aicardi-Goutieres-like, cleidocranial dysplasia and deletion of 18q. It is also well known that congenital hypothyroidism may be associated with other congenital malformations, especially with cardiac heart diseases, skeletal abnormalities, Central nervous system and eye malformations. In this article, 11-years-old-girl with fibula agenesis associated with congenital hypothyroidism because of thyroid gland hypoplasia is presented. In our knowledge, both congenital hypothyroidism and isolated fibula agenesis have not been published before in the literature.Öğe CONGENITAL HYPOTHYROIDISM WITH ISOLATED FIBULA AGENESIS(Nobel Ilac, 2010) Dogan, Murat; Yilmaz, Cahide; Caksen, Hueseyin; Cesur, Yasar; Akpinar, Fuat; Gueven, Ahmet SamiAlthough congenital hypothyroidism is seen often as an isolated case, it can also be seen as a part of some syndromes like Schinzel-Giedion, Aicardi-Goutieres-like, cleidocranial dysplasia and deletion of 18q. It is also well known that congenital hypothyroidism may be associated with other congenital malformations, especially with cardiac heart diseases, skeletal abnormalities, Central nervous system and eye malformations. In this article, 11-years-old-girl with fibula agenesis associated with congenital hypothyroidism because of thyroid gland hypoplasia is presented. In our knowledge, both congenital hypothyroidism and isolated fibula agenesis have not been published before in the literature.Öğe Effects of ebselen on radiocontrast media-induced hepatotoxicity in rats(Sage Publications Inc, 2013) Basarslan, Fatmagul; Yilmaz, Nigar; Davarci, Isil; Akin, Mustafa; Ozgur, Mustafa; Yilmaz, Cahide; Ulutas, Kemal TurkerOxidative stress is accepted as a potential responsible mechanism in the pathogenesis of radiocontrast media (RCM)-induced hepatotoxicity. Therefore, we aimed to investigate the protective effects of ebselen against RCM-induced hepatotoxicity by measuring tissue oxidant/antioxidant parameters and histological changes in rats. Wistar albino rats were randomly separated into four groups consisting of eight rats per group. Normal saline was given to the rats in control group (group 1). RCM was given to the rats in group 2, and both RCM and ebselen were given to the rats in group 3. Only ebselen was given to the rats in group 4. Liver sections of the killed animals were analyzed to measure the levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as histopathological changes. In RCM group, SOD and CAT levels were found increased. In RCM-ebselen group, MDA, SOD and CAT levels were found decreased. In RCM-ebselen group, however, GSH-Px activities of liver tissue increased. All these results indicated that ebselen produced a protective mechanism against RCM-induced hepatotoxicity and took part in oxidative stress.Öğe Evaluation of Lymphocyte Subgroups in Children With Down Syndrome(Sage Publications Inc, 2015) Yilmaz, Cahide; Dogan, Murat; Basarslan, Fatmagul; Yilmaz, Nebi; Yuca, Sevil; Bulan, Keziban; Kaya, AvniIn this study, lymphocyte subgroups including blood CD3, CD4, CD8, CD4/CD8, CD19, and CD16.56 values were analyzed in children with Down syndrome (DS). The study includes 85 children with DS, followed at Department of Pediatrics, Faculty of Medicine, Yuzuncu Yil University and 64 healthy age-matched control participants. Blood CD3, CD4, CD8, CD4/CD8, CD19, and CD16.56 values were examined in both the groups. Significantly decreased blood CD3, CD4, and CD19 values were found in the study group (P < .05) when compared with the control group. In conclusion, we would like to emphasize that blood CD3, CD4, and CD19 levels were found to be decreased in children with DS. Based on these finding, we think that these decreased lymphocyte subgroups might be responsible for increased susceptibility to infections in children with DS.Öğe The impact of different antiepileptic drugs on the sedation of children during magnetic resonance imaging(Elsevier Science Inc, 2014) Davarci, Isil; Karcioglu, Murat; Tuzcu, Kasim; Basarslan, Fatmagul; Davran, Ramazan; Yengil, Erhan; Yilmaz, CahideBackground and objectives: The induction and inhibition of cytochrome P450 isoenzymes by antiepileptic drugs lead to changes in the clearance of anesthetic drugs eliminated via hepatic metabolism. We investigated the duration of the sedation and additional anesthetic needs during magnetic resonance imaging in epileptic children receiving antiepileptic drugs that cause either enzyme induction or inhibition. Methods: In American Society of Anesthesiology I-II, 120 children aged 3-10 years were included. Group 1: children using antiepileptic drugs that cause cytochrome P450 enzyme induction; Group 2: those using antiepileptic drugs that cause inhibition; and Group 3: those that did not use antiepileptic drugs. Sedation was induced with the use of 0.05 mg kg(-1) midazolam and 1 mg kg(-1) propofol. An additional 0.05 mg kg(-1) of midazolam and rescue propofol (0.5 mg kg(-1)) were administered and repeated to maintain sedation. The duration of sedation and the additional sedation needed were compared. Results: The duration of the initial dose was significantly shorter in Group I compared with groups II and III (p = 0.001, p = 0.003, respectively). It was significantly longer in Group II compared with groups I and III (p = 0.001, p = 0.029, respectively). The additional midazolam needed for adequate sedation was increased in Group I when compared with groups II and III (p = 0.010, p = 0.001, respectively). In addition, the rescue propofol dose was significantly higher only in Group I when compared with Group III (p = 0.002). Conclusion: In epileptic children, the response variability to the initial sedative agents during the magnetic resonance imaging procedure resulting from the inhibition or induction of the cytochrome P450 isoenzymes by the antiepileptic drugs mandated the titration of anesthetic agents. Copyright (C) 2013 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.Öğe Intrathoracic Rib Associated with Pulmonary Collapse in a Pediatric Patient(Kowsar Publ, 2012) Basarslan, Fatmagul; Bayarogullari, Hanifi; Tutanc, Murat; Arica, Vefik; Yilmaz, Cahide; Davran, RamazanThe ribs are essential structures of the osseous thorax that provide certain significant information and aid interpretation of radiologic images in daily routine practice. Intrathoracic rib is a rare congenital anomaly that is usually discovered incidentally, but may cause in vain interventions in case of being unaware. We herein report an intrathoracic rib in a girl whose chest X-ray was strange enough to obtain a spiral computed tomography (CT) scanning for a definitive diagnosis afterwards.Öğe Kluver-Bucy syndrome developed after convulsion: A case report(2011) Okur, Mesut; Yilmaz, Cahide; Epçaçan, Serdar; Üstyol, Lokman; Kaya, Avni; Çaksen, HüseyinKluver-Bucy syndrome is characterized by increased appetite, hypersexuality, hypermetamorphosis, memory disorders, visual agnosia, stagnancy, aphasia, bulimia, polyuria, and polydipsia. A 14 year old girl had generalized tonic-clonic convulsions at admission, and an incomplete Kluver-Bucy syndrome with hypersexuality, recent memory disturbance, hypermetamorphosis, speech disturbance, hyperactivity, agitation, aggressiveness, and hallucinations, developed the following day. Here in, we report a case of KBS in a child with epilepsy.Öğe LATE ONSET ARGININE SUCCINATE LYASE DEFICIENCY WITH NORMAL PLASMA AMMONIA LEVEL(Nobel Ilac, 2011) Yilmaz, Cahide; Dogan, Murat; Cesur, Yasar; Caksen, Huseyin; Yuca, Sevil Ari; Atas, Bulent; Tuncer, OguzArginine succinate lyase (ASL) deficiency is one of the most common cause of urea cycle defect and shows all characteristics of this disorders. This disease is presented with hyperammonemia, abnormally kinky hair and mental retardation. 6-years-old-girl was brought to our hospital because of skin eruption, weight loses, abdominal pain, having no appetite, polydipsia and pollakiuria. In physical examination, especially occipital balding, mental retardation, hepatomegaly, ataxia and articulation defect were found. She, who was diagnosed as ASL deficiency after the laboratory examinations, had normal blood ammonia levels. Finally in this study, we emphasize; ASL deficiency must be thought when a child has mental retardation and cerebellar ataxia, even if normal ammonia levels.Öğe Late onset arginine succinate lyase deficiency with normal plasma ammonia level(2011) Yilmaz, Cahide; Do?an, Murat; Cesur, Yaşar; Çaksen, Hüseyin; Yuca, Sevil Ari; Ataş, Bülent; Tuncer, O?uzArginine succinate lyase (ASL) deficiency is one of the most common cause of urea cycle defect and shows all characteristics of this disorders. This disease is presented with hyperammonemia, abnormally kinky hair and mental retardation. 6-years-old-girl was brought to our hospital because of skin eruption, weight loses, abdominal pain, having no appetite, polydipsia and pollakiuria. In physical examination, especially occipital balding, mental retardation, hepatomegaly, ataxia and articulation defect were found. She, who was diagnosed as ASL deficiency after the laboratory examinations, had normal blood ammonia levels. Finally in this study, we emphasize; ASL deficiency must be thought when a child has mental retardation and cerebellar ataxia, even if normal ammonia levels.Öğe Magnetic Resonance Imaging Findings of the Abducens Nerves in Type 1 Duane's Retraction Syndrome(Taylor & Francis Inc, 2014) Tuzcu, Esra Ayhan; Bayarogullari, Hanifi; Atci, Nesrin; Basarslan, Fatmagul; Coskun, Mesut; Yilmaz, Cahide; Ilhan, NiluferPurpose: To investigate nervus abducens and extraocular mucles in patients with Type 1 Duane's retraction syndrome using high-definition magnetic resonance imaging. Methods: The study included 10 patients with Type I Duane's retraction syndrome who underwent magnetic resonance imaging (MRI) of the brain and orbits. Results: Overall, 10 cases were included in the study. There were seven women and three men. The mean age was 5.2 years (1-15 years). MRI of the abducens nerve was performed in all cases. Of the cases, the left eye was involved in eight cases, whereas the right eye was involved in two cases. There was no bilateral eye involvement. Among the 10 patients clinically diagnosed as Type 1 Duane's retraction syndrome, the abducens nerve could not be visualized in eight cases, whereas the nerve was hypoplastic in one case and bilateral abducens nerves were present in one case by MRI. The extraocular muscles were normal in all cases on T2 weighted coronal MRI of the orbits. Conclusion: Absence of abducens nerve and normal extraocular muscles was detected in patients with Type 1 Duane's retraction syndrome at the affected side.Öğe Mutations in LAMB1 Cause Cobblestone Brain Malformation without Muscular or Ocular Abnormalities(Cell Press, 2013) Radmanesh, Farid; Caglayan, Ahmet Okay; Silhavy, Jennifer L.; Yilmaz, Cahide; Cantagrel, Vincent; Omar, Tarek; Rosti, BasakCobblestone brain malformation (COB) is a neuronal migration disorder characterized by protrusions of neurons beyond the first cortical layer at the pial surface of the brain. It is usually seen in association with dystroglycanopathy types of congenital muscular dystrophies (CMDs) and ocular abnormalities termed muscle-eye-brain disease. Here we report homozygous deleterious mutations in LAMB1, encoding laminin subunit beta-1, in two families with autosomal-recessive COB. Affected individuals displayed a constellation of brain malformations including cortical gyral and white-matter signal abnormalities, severe cerebellar dysplasia, brainstem hypoplasia, and occipital encephalocele, but they had less apparent ocular or muscular abnormalities than are typically observed in COB. LAMB1 is localized to the pial basement membrane, suggesting that defective connection between radial glial cells and the pial surface mediated by LAMB1 leads to this malformation.Öğe Occuring Transverse Sinus Thrombosis Secondary to Chronic Otitis Media and Pseudotumor cerebri: Case Report(Duzce Univ, 2010) Okur, Mesut; Yilmaz, Cahide; Acar, Mehmet Nuri; Caksen, Huseyin; Kir, Faruk; Unal, Ozkan; Tuncer, OguzTransverse sinus thrombosis (TST), although not common as the former still, is a major complication of middle ear infection. In this study, with the diagnosis of middle ear infection for a period of 3 years followed outpatient and the developing transverse sinus thrombosis, 12 years old patient due to a rare case were presented. This case, therefore, children with chronic otitis media in terms of transverse sinus thrombosis and pseudotumor cerebri should be closely followed would like to emphasize.Öğe OPHTALMOPLEGIC MIGRAINE(Nobel Ilac, 2010) Dogan, Murat; Yilmaz, Cahide; Caksen, Huseyin; Guven, A. SamiOpthalmoplegic migraine is characterized with recurrent 3rd, 4th and/or 6th nerve palsy during or following ipsilateral periorbital or temporal headache. In this study, we report four years old child with opthalmoplegic migraine because of a rare occasion. The patient was brought to our hospital for the first time due to ptosis following headache, which continued for 4 days. From the history, it was learned that one year ago, ptosis which lasted for one week following headache, had occurred too. Neurological examination was normal except the complete third nerve palsy. Cranial magnetic resonance imaging and electroencephalography examinations were normal. One year later, the patient was brought to us again with the same complaint. Since the attacks were so few we didn't give him migraine proflaxy and we advice him to use analgesic during the attacks. The patient still comes to our hospital for periodic controlsÖğe Ophtalmoplegic migraine(2010) Do?an, Murat; Yilmaz, Cahide; Çaksen, Hüseyin; Güven, A. SamiOpthalmoplegic migraine is characterized with recurrent 3rd, 4th and/or 6th nerve palsy during or following ipsilateral periorbital or temporal headache. In this study, we report four years old child with opthalmoplegic migraine because of a rare occasion. The patient was brought to our hospital for the first time due to ptosis following headache, which continued for 4 days. From the history, it was learned that one year ago, ptosis which lasted for one week following headache, had occurred too. Neurological examination was normal except the complete third nerve palsy. Cranial magnetic resonance imaging and electroencephalography examinations were normal. One year later, the patient was brought to us again with the same complaint. Since the attacks were so few we didn't give him migraine proflaxy and we advice him to use analgesic during the attacks. The patient still comes to our hospital for periodic controls.
