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Öğe Evaluation of the structure, autoimmunity, and functions of the thyroid gland in familial Mediterranean fever patients(Sbem-Soc Brasil Endocrinologia & Metabologia, 2020) Yilmaz, Muge Ozsan; Celik, Muhammet Murat; Keles, Fatma Ozturk; Ozcan, OguzhanObjective: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder that is frequently seen in the eastern Mediterranean region. The thyroid gland can be affected in FMF patients through autoimmunity or amyloidosis. Here, we aimed to evaluate the structure and functions of the thyroid gland in addition to possible autoimmunity in FMF patients. Subjects and methods: The study was conducted by the Endocrinology and Metabolism and Internal Medicine Departments.Thirty FMF patients and 30 age and gender-matched healthy controls were enrolled in the study. Free thyroxin (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), and anti-thyroid peroxidase (anti-TPO) autoantibodies were investigated. Detailed thyroid grayscale and Doppler Ultrasonography examinations and shear-wave elastosonography (SWE) were performed in the patient and control groups. Results: Anti-TPO was detected in 24% (n = 7) of the patients. On the grayscale US, mean thyroid volumes were similar between the FMF and the control groups (p > 0.05). By Doppler US, thyroid vascularity observed was detected in 10.3% (n = 3) of the patients. SWE revealed that the mean velocity value of right vs. left lobe in the patient group was 1.77 +/- 0.45 m/s and 1.95 +/- 0.51 m/s, respectively. Compared to the control group, the mean velocity values were significantly higher in the right (p = 0.004) and left (p = 0.01) lobes of the patient group. The mean stiffness value in the patient group was also significantly higher in the right and left lobes [10.13 +/- 5.65 kPa (p = 0.005) and 12.24 +/- 6.17 kPa (p = 0.02), respectively]. Conclusion: Recognizing the complications of FMF early in the course of the disease is as important as the early diagnosis of the disorder. Based on this, thyroid functions and changes in its structure should be evaluated carefully for early diagnosis of a possible coexisting thyroid disorder.Öğe Investigation of Apelin Hormone Levels According to Body Mass Index and Waist Height Ratio Classification in Type 2 Diabetes Mellitus(Wiley, 2019) Acik, Duygu Egeli; Dogan, Hatice; Tutuk, Okan; Acik, Murat; Demir, Enver Ahmet; Yilmaz, Muge Ozsan; Tumer, Cemil[Abstract Not Available]Öğe Metabolic bone diseases in sickle cell anemia patients and evaluation of associated factors(Elsevier Science Inc, 2022) Eskiocak, Ozge; Yilmaz, Muge Ozsan; Ilhan, GulBackground: Metabolic or non-metabolic many bone diseases can be distinguished in sickle cell anemia. Patients with sickle cell anemia have a high risk of osteopenia and osteoporosis. The aim of this study is to reveal bone mineral density abnormalities and related factors in patients with sickle cell anemia. Methods: A total of 70 patients with sickle cell anemia were retrospectively included in our study. Complete blood count (CBC) parameters, serum creatinine, lactate dehydrogenase (LDH), total bilirubin, direct bilirubin, uric acid, calcium, phosphorus, parathormone, alkaline phosphatase, 25 (OH) vitamin D, ferritin, C reactive protein (CRP) and calculated bone mineral densitometry measurements by Dual-Energy X-ray Absorptiometry (DEXA) were assessed and recorded to the statistics program. We diagnosed osteopenia and osteoporosis according to World Health Organization (WHO) criteria. To determine the status of avascular necrosis and bone fracture, we examined x-ray and magnetic resonance imaging reports and epicrisis reports of patients from the records. Results: The average age was 30.01 +/- 8.64 years. Eighteen (26.5%) of the 68 patients whose Z-score was evaluated by DEXA had bone mass below the expected age-related range according to the Z score, while 50 (73.5%) had bone mass within the expected age-related range. Of the patients whose T score was evaluated by DEXA, 46.8% were normal (n=29), 45.1% were osteopenic (n=28) and 8.1% were osteoporotic (n=5). Conclusions: Patients with sickle cell anemia are at increased risk for osteoporosis, osteopenia, and osteomalacia. Bone health should be emphasized in these patients.Öğe Visceral Adipose Index and SIRT1 Gene Expression Relationship with Type 2 Diabetes Mellitus(Wiley, 2019) Acik, Duygu Egeli; Tutuk, Okan; Dogan, Hatice; Acik, Murat; Demir, Enver Ahmet; Yilmaz, Muge Ozsan; Tumer, Cemil[Abstract Not Available]
