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ASSOCIATION OF FETUIN-A WITH GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND OXIDATIVE STRESS IN SICKLE CELL ANEMIA
(Carbone Editore, 2016) Ulutas, Kemal Turker; Buyukbas, Sadik; Yilmaz, Nigar; Arpaci, Abdullah; Kaya, Hasan
Aim: Oxidative stress has crucial effects over vascular pathophysiology of Sickle Cell Anemia (SCA), and contributes atherosclerosis at advanced stages of the disease. In contrast to be acknowledged the possible role of Fetuin-A in the development of atherosclerosis, its association with vascular changes in SCA appears to warrant further investigation. In the study, we aimed to illuminate vascular pathophysiology of SCA via investigating Fetuin-A levels and its relationship with oxidative stress parameters. Material and methods: Fourty SCA patients and and 35 healthy individuals (n: 35) were included in the study all. After analyzing hematological data, Malondialdehyde (MDA), Glutathione Peroxidase (GSH-Px), Superoxide Dismutase (SOD) and Catalase (CAT) were measured throughout preparing hemolysate from samples with EDTA. Fetuin-A was analyzed from serum samples. Results: Fetuin-A (p<0.001) and MDA levels (p<0.001) were measured significantly higher in SCA group. Similarly, G6PD (p<0.001) and SOD (p<0.01) enzyme activities were determined higher in SCA when compared to the control group. A novel positive correlation was found among Fetuin-A, G6PD (r=0.435, p<0.0001) and MDA (r=0.547, p<0.0001). However, there was no statistical significance between the groups for CAT and GSH-Px. ROC analyze suggested 0,97 ng/mL as the cutoff value for Fetuin-A (Area Under the Curve: 0.713, sensitivity: 62%, specificity: 80%, p:0,002) and 0,06 mu mol/gr Hb as the cutoff value for MDA (Area Under the Curve: 0.898, sensitivity: 87 %, specificity: 80%, p:<0,001). Conclusion: Elevated Fetuin-A in patients with SCA and its positive correlations with both MDA and G6PD suggested that Fetuin-A might have an important role for pathophysiology of SCA. Additionally, Fetuin-A may be useful for evaluating severity of disease with high specificity cutoff value as MDA.
Calorie restriction modulates hippocampal NMDA receptors in diet-induced obese rats
(Taylor & Francis Ltd, 2011) Yilmaz, Nigar; Vural, Huseyin; Yilmaz, Mustafa; Sutcu, Recep; Sirmali, Rana; Hicyilmaz, Hicran; Delibas, Namik
Calorie restriction (CR) has attracted increased interest since CR enhances lifespan and alters age-related decline in hippocampal-dependent cognitive functions. Obesity is associated with poor neurocognitive outcome including impaired hippocampal synaptic plasticity and cognitive abilities such as learning and memory. N-Methyl-D-aspartate receptors (NMDARs) are linked to hippocampal-dependent learning and memory, which may be stabilized by CR. In the present study, we aimed to establish the effects of CR on NMDARs in CA1 region of hippocampus in obese and non-obese rats. In addition, malondialdehyde (MDA) levels were determined as a marker for lipid peroxidation (LPO) in hippocampus. Four groups were constituted as control group (C, n = 9), obese group (OB, n = 10), obese calorie-restricted group (OCR, n = 9), and non-obese calorie-restricted group (NCR, n = 10). OCR and NCR were fed with a 60% CR diet for 10 weeks. After 10 weeks of CR, the MDA levels significantly decreased in the calorie-restricted groups. Obesity caused significant decreases in NR2A and NR2B subunit expressions in the hippocampus. The hippocampal NR2A and NR2B levels significantly increased in the OCR group compared with the OB group (P < 0.05). In contrast, the hippocampal NR2A and NR2B levels significantly decreased in the NCR group compared with the C group (P < 0.05). Oxidative stress can be prevented by CR, and these data may provide a molecular and cellular mechanism by which CR may regulate NMDAR-mediated response against obesity-induced changes in the hippocampus.
Ceftriaxone ameliorates cyclosporine A-induced oxidative nephrotoxicity in rat
(Wiley, 2011) Yilmaz, Nigar; Ilhan, Selcuk; Naziroglu, Mustafa; Oktar, Suleyman; Nacar, Ahmet; Arica, Vefik; Tutanc, Murat
A growing body of evidence now suggested that cyclosporine A (CycA)-induced nephrotoxicity is a crucial clinical problem and oxidative stress is importantly responsible for its toxicity. Ceftriaxone induced antioxidant effect in brain and neuronal tissues against oxidative damage although its antioxidant potential effect on kidney has not been clarified. The aim of this study was to evaluate whether ceftriaxone protects CycA-induced oxidative stress kidney injury in rats. Twenty-four rats were equally divided into four groups. First group was used as control. Ceftriaxone (200 mg/kg) and CycA (15 mg/kg) were administrated to second and third groups for 10 days, respectively. The ceftriaxone and CycA combination was given to rats constituting the fourth group for 10 days. Lipid peroxidation (LP), urea nitrogen and lactate dehydrogenase (LDH) levels were higher in CycA group than in control and ceftriaxone groups although LP, urea nitrogen and LDH levels were lower in ceftriaxone + CycA group than in control and ceftriaxone groups. Glutathione peroxidase and catalase activities were lower in CycA group than in control whereas their activities were increased in control and ceftriaxone groups. Superoxide dismutase activity did not change by the treatments. Ceftriaxone administration recovered also CycA-induced atrophy, vacuolization and exfoliations of tubular epithelium and glomerular collapse in histopathological evaluation of kidney. In conclusion, we observed that ceftriaxone is beneficial on CycA-induced oxidative stress in kidney of rats by modulating oxidative and antioxidant system. Copyright (C) 2011 John Wiley & Sons, Ltd.
Determination of Phthalates Migrating from Plastic Containers into Beverages
(Springer, 2015) Ustun, Ihsan; Sungur, Sana; Okur, Ramazan; Sumbul, Ahmet Taner; Oktar, Suleyman; Yilmaz, Nigar; Gokce, Cumali
The determination of phthalates in beverages (soda, lemonade, cola, mineral water) sold in Turkish markets was carried out using gas chromatography-mass spectrometry (GC-MS). The mean phthalate concentrations were determined to be between 0.095 and 0.633 mg/L in soda, 0.018 and 1.219 mg/L in lemonade, 0.019 and 1.123 mg/L in cola, and 0.085 and 0.312 mg/L in mineral water. bis(2-Ethylhexyl) phthalate (DEHP) showed the highest level of migration into beverages. Furthermore, the influence of the type of preservative (sodium benzoate, potassium sorbate, sodium benzoate + potassium sorbate) and storage time were determined.
Diazinon-induced brain toxicity and protection by vitamins E plus C
(Sage Publications Inc, 2012) Yilmaz, Nigar; Yilmaz, Mustafa; Altuntas, Irfan
Diazinon (DI) is a widely used pesticide in agriculture, resulting in environmental deleterious effects on neural systems. The current study was performed to investigate the effects of treatment with vitamins E plus C on brain toxicity, which is possibly induced by DI. Twenty-one male rats were divided into three groups (n = 7/group) as follows: (1) control group (C); (2) DI-treated group (DI); (3) DI + vitamins E plus C-treated group (DI + Vit). In order to examine lipid peroxidation and antioxidant status in rats, the level of malondialdehyde (MDA), activities of two free radical scavanging enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) have been studied in brain of rat. The results showed that treatment with DI induced significant (p < 0.05) increases in the level of serum MDA in rat brain. The vitamins E plus C combination reduced lipid peroxidation in rat brain. The activity of SOD level was significantly higher in DI + Vit group, compared to the control group. GSH-Px, SOD and CAT values were not significantly different in the DI group than in control. Oxidative stress contributes to DI-induced brain toxicity. Our results suggested that vitamins E plus C combination may have a protective effect on DI-induced brain toxicity.
Effects of ?-Glucan Pretreatment on Acetylsalicylic Acid-Induced Gastric Damage: An Experimental Study in Rats
(Elsevier Science Inc, 2010) Ozkan, Orhan Veli; Ozturk, Oktay Hasan; Aydin, Mehmet; Yilmaz, Nigar; Yetim, Ibrahim; Nacar, Ahmet; Oktar, Suleyman
BACKGROUND: NSAIDs have been found to induce gastrointestinal tract damage. Recently, it has been suggested that this might be mediated by lipid peroxidation. OBJECTIVE: The aim of this study was to assess the potential protective effects of beta-glucan against acetylsalicylic acid (ASA)-induced gastric damage by means of its antioxidant capacity in an experimental rat model. METHODS: Thirty-two male Wistar albino rats (200-250 g) were randomized into 4 groups consisting of 8 rats each. The beta-glucan group received 50 mg/kg beta-glucan once a day for 10 days and 30 minutes before anesthesia. The ASA group received saline once a day for 10 days and 300 mg/kg (20 mg/mL) ASA as a single dose, 4 hours before anesthesia. The ASA+beta-glucan group was administered 50 mg/kg beta-glucan once a day for 10 days and 30 minutes before anesthesia. Additionally, 300 mg/kg (20 mg/mL) ASA was administered as a single dose, 4 hours before anesthesia. The control group received saline once a day for 10 days and 30 minutes before anesthesia. All medications were administered by intragastric gavage. The stomach from each rat was dissected and divided into 2 parts for histologic and biochemical analysis. Gastric tissue malondialdehyde (MDA), nitric oxide (NO) levels, catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities were determined for oxidative parameter analysis. RESULTS: The gastroprotective and antioxidant effects of beta-glucan appeared to attenuate the ASA-induced gastric tissue damage. Compared with the control group, MDA and NO levels and CAT and GSH-Px activities were significantly increased in the stomachs of ASA-treated rats (MDA, 4.12 [0.44] to 13.41 [1.05] mu mol/L; NO, 8.04 [7.25-9.10] vs 30.35 [22.34-37.95] mu mol/g protein; CAT, 0.050 [0.004] to 0.083 [0.003] k/g protein; GSH-Px, 0.57 [0.42-0.66] to 1.55 [1.19-1.76] U/L; all, P < 0.001), whereas SOD activity was significantly decreased in the same group (291 [29] to 124 [61 U/mL; P < 0.001). In the ASA+beta-glucan group, MDA and NO levels and CAT and GSH-Px activities were found to be significantly lower, while SOD activity was found to be significantly higher, in comparison with the ASA-treated group (all, P < 0.001). CONCLUSION: beta-Glucan appeared to attenuate the gastric damage caused by ASA in these rats. (Curr Ther Res Clin Exp. 2010;71:369-383) (C) 2010 Elsevier HS Journals, Inc.
Effects of caffeic acid phenethyl ester on isoproterenol-induced myocardial infarction in hypertensive rats
(Taylor & Francis Inc, 2010) Oktar, Suleyman; Yilmaz, Nigar; Ilhan, Selcuk; Sahna, Engin
[Abstract Not Available]
Effects of ebselen on radiocontrast media-induced hepatotoxicity in rats
(Sage Publications Inc, 2013) Basarslan, Fatmagul; Yilmaz, Nigar; Davarci, Isil; Akin, Mustafa; Ozgur, Mustafa; Yilmaz, Cahide; Ulutas, Kemal Turker
Oxidative stress is accepted as a potential responsible mechanism in the pathogenesis of radiocontrast media (RCM)-induced hepatotoxicity. Therefore, we aimed to investigate the protective effects of ebselen against RCM-induced hepatotoxicity by measuring tissue oxidant/antioxidant parameters and histological changes in rats. Wistar albino rats were randomly separated into four groups consisting of eight rats per group. Normal saline was given to the rats in control group (group 1). RCM was given to the rats in group 2, and both RCM and ebselen were given to the rats in group 3. Only ebselen was given to the rats in group 4. Liver sections of the killed animals were analyzed to measure the levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as histopathological changes. In RCM group, SOD and CAT levels were found increased. In RCM-ebselen group, MDA, SOD and CAT levels were found decreased. In RCM-ebselen group, however, GSH-Px activities of liver tissue increased. All these results indicated that ebselen produced a protective mechanism against RCM-induced hepatotoxicity and took part in oxidative stress.
Effects of Venlafaxine and Escitalopram Treatments on NMDA Receptors in the Rat Depression Model
(Springer, 2011) Yilmaz, Nigar; Demirdas, Arif; Yilmaz, Mustafa; Sutcu, Recep; Kirbas, Aynur; Cure, Medine Cumhur; Eren, Ibrahim
Depression may relate to neurocognitive impairment that results from alteration of N-methyl-d-aspartate receptor (NMDAR) levels. Venlafaxine and escitalopram are two drugs commonly used to treat depression. The drugs may affect expression of NMDARs, which mediate learning and memory formation. The aim of the study was to examine whether the effects of venlafaxine and escitalopram treatments are associated with NMDARs in a rat model of depression. Forty male Wistar albino rats were randomly divided into four groups (n = 10) as follows: control group, chronic mild stress group (CMS), venlafaxine (20 mg/kg body weight per day) + CMS, and escitalopram (10 mg/kg body weight per day) + CMS. After induction of depression, a decrease in the concentration of NR2B was observed; venlafaxine treatment prevented the reduction of NR2B expression. Escitalopram treatment did not effect the reduced levels of NR2B resulting from depression. There was no significant difference in NR2A concentration among groups. The present data support the notion that venlafaxine plays a role in maintaining NR2B receptor in experimental depression. It may be possible that treatment with escitalopram has no effect on NMDARs in experimental depression.
Investigation of Parvovirus B19 Seroprevalence, Endothelin-1 Synthesis, and Nitric Oxide Levels in the Etiology of Essential Hypertension
(Taylor & Francis Inc, 2012) Motor, Vicdan Koksaldi; Arica, Secil; Motor, Sedat; Yilmaz, Nigar; Evirgen, Omer; Inci, Melek; Gokce, Cumali
Background and Aims: Many studies have focused on the role of pathogen infection in hypertension (HT). It has been postulated that increased vascular tonus in HT is basically related to the imbalance between vasodilator, such as nitric oxide (NO), and vasoconstrictor, such as endothelin-1 (ET-1), substances secreted by endothelium. The aim of the present study was to investigate the seroprevalence of human parvovirus B19 (HPV B19) in the etiology of essential HT and the effect of HPV B19 on ET-1 and NO levels in this disorder. Materials and Methods: A total of 135 participants were enrolled in the study (90 patient and 45 controls). Antibodies to HPV B19 and ET-1 were measured by enzyme-linked immunosorbent assay method. Nitric oxide levels were calculated according to the Griess reaction. Results: Of the total participants, 27 patients (30%) and 7 control subjects (15.6%) had IgM positive (P = .068), whereas 27 patients (30%) and 14 control subjects (31.1%) had IgG positive (P = .895). There was no statistical difference between patients and control subjects in terms of serum ET-1 and NO levels. Conclusions: The role of HPV B19 in the etiology of essential HT was not shown in the present study. A larger sample may be needed for the investigation of these relations.
Investigation of vitamin D levels in patients with inactive hepatitis B virus carrier
(Acta Medica Mediterranea, 2014) Motor, Sedat; Koksaldi-Motor, Vicdan; Dokuyucu, Recep; Ustun, Ihsan; Evirgen, Omer; Yilmaz, Nigar; Onlen, Yusuf
Objective: The purpose of the present study was to investigate vitamin D levels in inactive hepatitis B virus carriers. Materials and methods: A total of 81 patients with inactive hepatitis B virus carrier state were enrolled at the study. Serum calcium (Ca++), phosphorus (PO4), total protein, albumin, parathormone (PTH) and 25-hydroxy vitamin D (25OHD) were determined. Serum vitamin D concentration was classified as lacking when it was less than 50 nmol/l (20 ng/ml), insufficient when it was 52.5-72.5 nmol/l (21-29 ng/ml), and sufficient when it was more than 75 nmol/l (30-100 ng/ml). Results: The mean 25OHD level was found to be 131.7±50.0 nmol/l. Deficiency and insufficiency was seen in one (1.2 %) and nine (11.1 %) inactive hepatitis B virus carriers, respectively. All the patients have normal serum PTH and albumin levels. Total Ca++ and PO4 were low in ten and eight patients, respectively (p<0.05). Conclusion: Vitamin D may cause the stimulation of antiviral immune response and a preventive effect on necroinflammation and liver fibrosis. Therefore, it may affect course of HBV infection. The new studies with larger sample are needed to research the role of vitamin D in the course of chronic HBV infection, liver failure, cirrhosis, and hepatocellular carcinoma.
INVESTIGATION OF VITAMIN D LEVELS IN PATIENTS WITH INACTIVE HEPATITIS B VIRUS CARRIER
(Carbone Editore, 2014) Motor, Sedat; Koksaldi-Motor, Vicdan; Dokuyucu, Recep; Ustun, Ihsan; Evirgen, Omer; Yilmaz, Nigar; Onlen, Yusuf
Objective: The purpose of the present study was to investigate vitamin D levels in inactive hepatitis B virus carriers. Materials and methods: A total of 81 patients with inactive hepatitis B virus carrier state were enrolled at the study. Serum calcium (Ca++), phosphorus (PO4), total protein, albumin, parathormone (PTH) and 25-hydroxy vitamin D (25OHD) were determined. Serum vitamin D concentration was classified as lacking when it was less than 50 nmolll (20 ng/ml), insufficient when it was 52.5-72.5 nmol/l (21-29 ng/ml), and sufficient when it was more than 75 nmol/l (30-100 ng/ml). Results: The mean 25OHD level was found to be 131.7 +/- 50.0 nmol/l. Deficiency and insufficiency was seen in one (1.2 %) and nine (11.1 %) inactive hepatitis B virus carriers, respectively. All the patients have normal serum PTH and albumin levels. Total Ca++ and PO4 were low in ten and eight patients, respectively (p<0.05). Conclusion: Vitamin D may cause the stimulation of antiviral immune response and a preventive effect on necroinflammation and liver fibrosis. Therefore, it may affect course of HBV infection. The new studies with larger sample are needed to research the role of vitamin D in the course of chronic HBV infection, liver failure, cirrhosis, and hepatocellular carcinoma.
Investigation of Vitamin D Levels in Patients with Vitiligo Vulgaris
(Croation Dermatovenerological Soc, 2014) Ustunl, Ihsan; Serastan, Gamze; Gokce, Cumali; Motor, Sedat; Can, Yesim; Inan, Mehmet Ugur; Yilmaz, Nigar
The aim of the study was to investigate serum 25-hydroxyvitamin D (25(OH) D,) levels in patients with vitiligo vulgaris in terms of causal relation and extension of the disorder. This study is a clinical cross-sectional study carried out in order to determine 25-hydroxyvitamin D levels among 25 patients with vitiligo vulgaris and in 41 controls. Fitzpatrick skin phototypes, history of autoimmune disease, family history of vitiligo, and duration of the disease were also evaluated. The mean levels of vitamin D in patient and the control group were 15.2 +/- 5.2 ng/dL and 14.4 +/- 6.2 ng/dL respectively (P>0.05). In our study, 48% of the patients had insufficient (<30 ng/nnL) and 52% had very low (<15 ng/mL) levels of vitamin D. There was no correlation between age, duration of the disease, and body surface area affected with vitamin D levels. There was no significant difference in vitamin D levels between patients who had family history of vitiligo (5 patients, 20%) and those that did not. Vitamin D levels were found to be insufficient (<30 ng/mL) or very low (<15 ng/mL) in most of the patients with vitiligo vulgar's, but not statistically significantly different as a group when compared to the controls. More studies are needed to differentiate between the effects of low vitamin D levels on pathogenesis of vitiligo vulgaris and lower vitamin D levels as a result of the disease.
The protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in rats
(Sage Publications Inc, 2016) Meydan, Sedat; Nacar, Ahmet; Ozturk, Hasan Oktay; Tas, Ufuk; Kose, Evren; Zararsiz, Ismail; Yilmaz, Nigar
Caffeic acid phenethyl ester (CAPE) has antioxidant and anti-inflammatory properties. The aim of this study is to examine the negative effects of toluene on kidney tissues and functions and to investigate the protective effects of CAPE against toluene-induced nephrotoxicity in rats. A total of 21 male Wistar rats were divided into three groups of equal number in each. The rats in group I were the controls. Toluene was intraperitoneally injected into the rats in group II with a dose of 500 mg/kg. Rats in group III received CAPE daily while exposed to toluene. After 14 days of experimental period, all rats were killed by decapitation. Enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) and malondialdehyde (MDA) levels were studied in the rat kidneys. Blood urea nitrogen (BUN) and serum creatinine levels were measured for renal function. The CAT and SOD enzyme activities and serum creatinine levels were significantly increased in rats treated with toluene when compared with the controls. But GSH-Px activity, MDA, and BUN levels showed statistically nonsignificant changes. However, increased CAT and SOD enzyme activities and decreased serum creatinine levels were detected in the rats that received CAPE while exposed to toluene. The GSH-Px activity and MDA and BUN levels in the same group did not show statistically significant changes. The results of our study demonstrated that toluene damages kidney tissue and is a nephrotoxic substance. CAPE was able to prevent the renal damage as antioxidant, antitoxic, and nephroprotective agent.
The relationship between ghrelin and adiponectin levels in breast milk and infant serum and growth of infants during early postnatal life
(Springer Japan Kk, 2012) Cesur, Gokhan; Ozguner, Fehmi; Yilmaz, Nigar; Dundar, Bumin
Ghrelin and adiponectin have been found in breast milk and are considered to take part in the regulation of growth and energy metabolism of infants. Our aims were to determine ghrelin and adiponectin levels in breast milk and serum samples of mothers and their infants, and to investigate the relationship between their levels and anthropometry of newborn infants during early postnatal life. Total and active ghrelin and adiponectin levels were studied in breast milk, and the serum samples of 25 healthy lactating women and their healthy fullterm infants were taken at the 1st and 4th months of life. Anthropometric measurements of infants were also performed during the study period. Breast milk and infant serum active ghrelin levels were found to be significantly increased at the 4th month of life compared with 1st month levels (p < 0.05). Maternal serum total ghrelin and infant serum adiponectin levels were found to be significantly reduced at the 4th month of life (p < 0.05). Breast milk active ghrelin levels were higher than the infant and maternal serum active ghrelin at the 1st and 4th months (p < 0.05). There was a negative significant correlation between the level of infant serum active ghrelin levels and BMI of infants at the 1st month. A positive significant correlation was found between the level of 1st month infant serum adiponectin levels and weight gain of infants during the study period. Fourth month infant serum adiponectin were also positively correlated with weight and BMI of infants at the 4th month and the weight gain during study period. There was a positive significant correlation between the level of 4th month breast milk active ghrelin and weight gain of infants during the study period. Ghrelin and adiponectin are involved in postnatal growth of infants. Ghrelin in breast milk also seems to be related to the growth of infants during early postnatal life. The sources of these peptides in breast milk are probably both maternal serum and breast tissue itself.
The relationship between phthalates and obesity: serum and urine concentrations of phthalates
(Edizioni Minerva Medica, 2017) Oktar, Suleyman; Sungur, Sana; Okur, Ramazan; Yilmaz, Nigar; Ustun, Ihsan; Gokce, Cumali
BACKGROUND: A limited number of human and animal studies suggest that a relationship exists between phthalates and obesity, although this is not supported by all research. The purpose of this study was to investigate the relationship between Body Mass Index (BMI) and the levels of phthalates in human blood and urine samples. METHODS: Sixty-four overweight or 132 obese individuals (total=196) of different ages (min-max, 17-62; mean SD, 42.07 +/- 11.3) and genders (F:M 97:99) enrolled in the study. BMI and waist circumference were measured to diagnose obesity. Venous blood samples were taken after overnight fasting. To compare the urine phthalates among participants, single spot urine (at least 10 mL) was collected from the subject after blood samples were taken. Urine and blood phthalate concentrations were measured using gas chromatography. RESULTS: Total blood/urinary phthalate levels significantly increased in proportion to the degree of obesity. There was a high correlation between the level of total phthalates in serum and BMI (p=0.697, P<0.001), and between total urinary phthalate levels and BMI (p=0.707, P<0.001). CONCLUSIONS: This is the first study to have shown that both blood and urinary phthalates increased in proportion to BMI. The results show a strong association between obesity and phthalates.
Relationship between Serum Resistin and Lipid Levels in Patients with Psoriasis
(Cukurova Univ, Fac Medicine, 2015) Yilmaz, Nigar; Ulutas, Kemal Turker; Dogramaci, A. Cigdem; Inan, M. Ugur; Yuksel, Rana; Can, Yesim
Purpose: Psoriasis is inflammatory skin disease which has increased risk of cardiovascular disease. The etiology is unknown, yet. In cardiovascular disease, resistin which is secreted from adipose tissue, was found correlated with the levels of total cholesterol and LDL. In our study, we aimed to study the relation of serum resistin and lipid levels in patients with psoriasis and correlation of Psoriasis Area and Severity Index (PASI). Material and Methods: In Mustafa Kemal University, Faculty of Medicine, Department of Dermatology, thirty-seven healthy subjects (group I) and thirty-four patients with psoriasis (group II) were enrolled for two groups. The age, gender, blood pressure, body mass index (BMI) and PASI were determined. The level of resistin and lipid profile were studied in serum. Results: The level of resistin in patients with psoriasis (12,3 +/- 3,0 ng/ml) was found increased compared with healthy subjects (6,4 +/- 2,3 ng/ml) (p=0.001). The level of total cholesterol and LDL were increased in patients with psoriasis compared with healthy subjects, respectively (189 +/- 43 mg/dl; 129 +/- 31 mg/dl) (p<0,05; p=0,01). The level of resistin was determined correlated positively with LDL (r=0,306). The level of resistin was found strong correlated positively with PASI (r=0,669). Conclusion: The high risk of cardiovascular disease in patients with psoriasis is known. In our study, the levels of resistin, total cholesterol, LDL which increase in cardiovascular disease, was found increased in patients with psoriasis and correlated with PASI. The level of resistin may be increased with increasing severity of the disease, so that it is thought to be significant determining like the lipid profile in patients with psoriasis.

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