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Öğe A case of neurobrucellosis(Turkish Society of Cerebrovascular Diseases, 2011) Okuyucu, E. Esra; Yilmazer, Serkan; Dede, Hava Özlem; Melek, Ismet; Duman, TaşkinCausing serious morbidities and having so many different clinic formes are the clinical importances of brucellosis, which is a zoonotic infections. Neurobrucellosis, can appear with cranial nerve pathologies, optic stasis, menengitis, myelitis, radiculopathy, periferic neuropathy etc. The case is the woman who is 69 years old. Her complaints began as lumbar pain 3 years ago. She has not been able to stand unaided for a year. In the periventricular white matter chronic ischemic lessions, and in the right serebellar hemisfer an encephalomalasia were determined in the kranial MRI. Brucella tube agglitunation was 1/160(+). Clinic remission observed after neurobrucellosis treatment. The neurobrucellosis is a manifestation that can appear in a lot of different clinic formes; and it requires attention in the differential diagnoastics of several diseases.Öğe Does transcutaneous nerve stimulation have effect on sympathetic skin response?(Elsevier Sci Ltd, 2018) Okuyucu, E. Esra; Turhanoglu, Ayse Dicle; Guntel, Murat; Yilmazer, Serkan; Savas, Nazan; Mansuroglu, AyhanObjective: This study examined the effects of transcutaneous electrical nerve stimulation (TENS) on the sympathetic nerve system by sympathetic skin response test. Methods: Fifty-five healthy volunteers received either: (i) 30 minutes TENS (25 participants) (ii) 30 minutes sham TENS (30 participants) and SSR test was performed pre- and post-TENS. The mean values of latency and peak-to-peak amplitude of five consecutive SSRs were calculated. Results: A significant amplitude difference was found between TENS and sham TENS group both in right and left hand (p = 0.04, p = 0.01, respectively). However there was no significant latancy difference between two groups (p>0.05). Conclusion: TENS has an inhibitory effect on elicited SNS responses when compared with sham TENS control group. (C) 2017 Elsevier Ltd. All rights reserved.Öğe EEG abnormalities during treatment with tadalafil, a phosphodiesterase type 5 inhibitor(Taylor & Francis Ltd, 2009) Okuyucu, Esra E.; Guven, Oguz; Duman, Taskin; Gorur, Sadik; Melek, Ismet M.; Akcin, Soner; Yilmazer, SerkanObjective: Tadalafil is a selective phosphodiesterase type 5 (PDE-5) inhibitor approved for the treatment of erectile dysfunction. Less is known about the electroencephalography (EEG) effects of PDE-5 inhibitors, and the present study, therefore, examined the risk of EEG abnormalities associated with tadalafil. Method: EEG recordings from 35 erectile dysfunction patients taking tadalafil (20 mg) were graded for severity of EEG abnormalities (at admission, 2 and 48 hours after tadalafil administration). Results: At admission, there were no EEG abnormalities. At second EEG, abnormalities occurred in 12 (34.3%) of the 35 patients. Eight (22.9%) patients had mild and four (11.4%) patients had moderate EEG abnormalities. At third EEG, one (2.9%) patient had mild and one (2.9%) patient had moderate EEG abnormalities. Conclusion: PDE-5 inhibitors may produce EEG abnormalities. Although the exact role of PDE in altering susceptibility to seizure remains unclear, epileptic seizures may occur during treatment with PDE inhibitors. [Neurol Res 2009; 31: 313-315]Öğe Generalized anhidrosis(Riyadh Armed Forces Hospital, 2013) Yilmazer, Serkan; Okuyucu, Esra; Melek, Ismet; Duman, Taskin[Abstract Not Available]Öğe Probability of stroke in the couples of stroke patients; using Framingham Stroke Risk Profi?le(Turkish Society of Cerebrovascular Diseases, 2012) Duman, Taşkin; Okuyucu, Esra E.; Melek, Ismet M.; Yilmazer, Serkan; Inandi, Tacettin; Mengüllüo?lu, NecdetINTRODUCTION: Environmental and personal factors may be of importance for stroke risk. We determined the stroke risk factors among the stroke patients' couples and controls. MATERIAL AND METHODS: A prospective study was conducted on 221 participants (71 stroke patients, 71 stroke patients' couples, 79 controls) aged more than 54 years. Framingham Stroke Risk Profile was used to measure the stroke risk. RESULTS: In subjects aged 54 years and older, became a couple of stroke patient were not associated with an increased risk of stroke. CONCLUSION: In this study, environmental and personal factors were an independent risk factor for stroke in stroke patients' couples and controls older than 54 years.Öğe Subclinical Peripheral Neuropathy in Behcet's Disease(Deri Zuhrevi Hastaliklar Dernegi, 2009) Okuyucu, Esra Emine; Balci, Didem Didar; Turhanoglu, Ayse; Duman, Taskin; Yilmazer, Serkan; Yenin, Juelide ZehraBackground and Design: Central nervous system involvement is well known in patients with Behcet's disease but studies evaluating peripheral nervous system is not usual. The aim of this study is to evaluate the frequency and characteristics of subclinical neuropathy in patients with Behcet's disease. Material and Method: Thirty three Behcet's disease patients (23 male, 10 women) with no evident neurological sign and symptom and 33 healthy volunteers were enrolled to the study. To exclude the other causes of peripheral neuropathy, some laboratory investigations were made. Electrophysiological studies of peripheral nerves were performed to all patients and healthy volunteers. The results were assessed according to the American Diabetes Association Diabetic Neuropathy Protocol. Results: Nerve conduction studies were abnormal in 11 of 33 patients (7 men, 4 women; 33.3%). Five patients (15%) had sensorymotor polyneuropathy, 4 (12%) has sural sensory polyneuropathy, 1 (3%) had median and tibial motor neuropathy. Sural nerve were unobtainable in 7 (21%) patients. 2 patients (6%) had prolonged F latency. Control group were normal electrophysiologically and the difference was statistically important (p < 0.0001). There was no correlation between peripheral neuropathy and gender (p=0.696). Conclusion: Despite the detailed neurological examination, subclinical peripheral neuropathy can be seen in patients with Behcet's disease. Electrophysiological studies are useful for the early detection of peripheral neuropathy in these patients. (Turkderm 2009; 43: 61-4)
