Yazar "Yuksek, N." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Assessment of electrocardiographic findings, serum nitric oxide, cardiac troponins and some enzymes in calves with hyperkaliemia related to neonatal diarrhoea
    (Ecole Nationale Veterinaire Toulouse, 2011) Ozkan, C.; Altug, N.; Yuksek, N.; Kaya, A.; Akgul, Y.
    The aims of the present study were to characterize ECG changes in calves with hyperkaliemia due to neonatal diarrhoea and to determine concomitant variations of serum concentrations of NO and of sonic cardiac markers such as cardiac troponins I and T and serum enzyme AST, LDH, CK and CK-MB activities. For that, ECG examinations were performed and serum biochemical parameters were measured in 13 diarrhoeic calves developing hyperkaliemia before and 5 hours after intravenous electrolyte (NaCl and Na2HCO3) administration and also in 5 healthy control calves. Compared to controls, diarrhoeic and hyperkaliemic calves exhibited significant alterations in electrolyte concentrations (Increases of K, Mg and P concentrations coupled to decreases of Na and Cl concentrations), a significant blood accumulation of nitrogen compounds (BUN and creatinine) and significant increases in ALP, LDH, CK and GGT activities. Furthermore, the serum NO concentrations have greatly enhanced in some individuals. By contrast, the serum troponin concentrations and the heart specific CK-MB and AST activities were similar between the 2 groups whereas electrocardiography changes were evidenced in diarrhoeic calves: P wave anomalies were observed in sonic diseased calves and the mean amplitude and the mean duration of the QRS complex and the T wave were markedly increased. The fluid electrolyte therapy has restored the electrolyte balance and has globally improved the parameters of the cardiac function but has failed to counteract the blood azote accumulation and the release of ALP, LDH, CK and GOT enzymes and even has aggravated the decreases in total protein and albumin concentrations and the glycaemia variations. These results suggest that the diarrhoea-related hyperkaliemia has led to disturbances into the cardiac function without inducing severe myocardium lesions in calves but was coupled to acute renal failure.
  • Küçük Resim
    Öğe
    Enhancement of the glucose metabolism and the reverse cholesterol transport by a peroxisome proliferator receptor ? (PPAR?) agonist included in the fasciolosis treatment in naturally infested sheep
    (Ecole Nationale Veterinaire Toulouse, 2013) Yuksek, N.; Altug, N.; Denizhan, V.; Ceylan, E.; Agaoglu, Z.
    The purpose of this study was to investigate the effects of PPAR alpha agonist on metabolic parameters in naturally Fasciola-infected sheep. Twenty sheep with fasciolosis were allotted in 2 equal groups according to the received treatment (triclabendazole/levamisole in the group I and triclabendazole/levamisole + PPAR alpha agonist (2-methyl-2-phenoxy-propionic acid) in the group II) and the haematological and biochemical parameters were assessed before the treatment and 7, 14 and 28 days after and were compared to control values determined from 10 healthy sheep. As expected, fasciolosis has induced an anaemia evidenced by low haematocrit and low haemoglobinemia coupled to eosinophilia and to a moderate lymphopenia, severe liver damage characterised by hepatocyte degenerescence (significant increases in serum AST and GDH activities) and bile duct obstruction (significant increases in serum GGT activity and in serum bile acid concentrations) leading to impairement in liver metabolic functions (hypoalbuminemia, marked decreases in serum glucose concentrations and in LDL associated cholesterol concentrations). All the heamatological and biochemical alterations were at least partially alleviated by the antihelminthic treatment except the serum triglyceride concentrations which have continued to decrease during the post-treatment period and the total cholesterol and HDL associated cholesterol concentrations which have markedly increased, particularly when sheep were also treated with the PPAR alpha agonist. These results clearly demonstrated the severe metabolic liver impairment occurring during fasciolosis in sheep and the beneficial effects of the PPAR alpha agonist on the correction of the negative energy balance, particularly by promoting the reverse cholesterol transport.