Interdisciplinary Medical Journal Collection
Bu koleksiyon için kalıcı URI
Güncel Gönderiler
Öğe Determination of 25 hydroxyvitamin D reference ranges in Hatay region by indirect method(2023) Oğuzman, Hamdi; Doğan, SerdarObjective: The aim of this study is to determine the reference ranges of 25 hydroxyvitamin D (25(OH)D) levels from the serum 25(OH)D results of the patients and to investigate variations across age and gender groups. Methods: The patients (n=26829) who applied to Hatay Mustafa Kemal University Hospital between January 2018 and December 2019 and whose 25(OH)D levels were studied were included in this retrospective study. Serum 25(OH)D levels were studied by the chemiluminescence immunoassay method. The hospital information management system was used to obtain the test results and patient data. The indirect method was used to determine the reference ranges. Results: The prevalence of 25(OH)D deficiency in the patients participating in this study was 60.9% in the general population, 54.9% in men, and 67.5% in women. It has been observed that 25(OH)D deficiency is more common in women than in men. The reference ranges determined in this study were lower than the reference ranges provided by the manufacturer. Conclusion: In this study, 25(OH)D levels and reference ranges of Hatay Region were determined in a very large population. It can be said that the results of our region will contribute to the studies to be carried out on the determination of 25(OH)D levels and reference ranges throughout the country.Öğe The relationship of preterm birth with fetal fibronectin level in cervicovaginal fluid and cervical lenght in ultrasonography(2023) Arpacı, Anıl; Karapınar, Oya SoyluObjective: In this study, the compatibility between fetal fibronectin determination and the use of cervical length measured by transvaginal ultrasonography of patients who were at risk of preterm birth in the examination performed at 24-34 weeks of gestation, and patients with an increased risk of preterm birth according to the result were defined. Method: 40 patients who applied to Mustafa Kemal University Training and Research Hospital Gynecology and Obstetrics outpatient clinic between May 2021 and May 2022 were included in the study. Fibronectin results were evaluated using the liquid ELISA method taken from the vaginal secretion by a swap. Cervical lengths were evaluated as 25 mm and below, between 25-30 mm and 30 mm and above in statistical data. Results: For fFN-positive patients, the preterm delivery rate of patients with a cervical length of 25 mm and less was determined as 100%, while the rate of preterm birth was determined as 77.8% for patients with a cervical length between 25 mm and 30 mm. In addition, the preterm labor rate of fFN-positive patients with a cervical length of 30 mm and above was determined as 78.57%. Conclusion: All patients with a cervical length of 25 mm or less have a positive fFN test, and a strong correlation can be established between these two values. Accordingly, fFN positivity was found to have a higher sensitivity in determining the probability of preterm delivery compared to the cervical length ratio.Öğe Assessment of relationship between different communication methods and treatment compliance in orthodontic patients during Covid-19 pandemics(2023) Yılmaz, Hakkı; Zortuk, Fundagül Bilgiç; Köse, İlter BurakObjective: The aim of this study was to minimize impairment in oral hygiene and failure of brackets; therefore, effects of pandemic on treatment duration, by communicating our patients using 4 different methods during Covid-19 pandemic. Methods: In the study, 227 patients undergoing fixed orthodontic treatment were included. Five groups were designed: WhatsApp group, short message service (SMS) group, Teledentistry group, e-mail group and control group. During quarantine period, patients were contacted for 4 times and same text was sent to patients. After pandemics, the patients were assessed using mucogingival index (MGI), orthodontic plaque index (OPI) and failure of brackets was determined. Results: In MGI, percentage of patients with healthy result were as follows: WhatsApp group, 83.7%; SMS group, 87.8%; Teledentistry group, 83.7%; E-mail group, 77.5%; control group, 72.2% and no significant difference was found (p>0.05). The OPI scores were as follows: 1.12±1.24 in WhatsApp group; 1.27±1.28 in SMS group; 1.24±1.38 in Teledentistry group; 1.00±1.22 in E-mail group; and 1.61±1.25 in the control group and no significant difference was found (p>0.05). The mean number of brackets broken was 0.47±0.88 in WhatsApp group, 0.39±0.83 in SMS group, 0.51±1.00 in Teledentistry group, 0.40±0.67 in E-mail group and 0.44±0.86 in the control group and no significant difference was found (p>0.05). Conclusion: It was determined that communicating with patients in different ways did not make any difference in terms of the subjects investigated in the study. It was concluded that it would be more appropriate to conduct new studies including social and psychological evaluations.Öğe The relationship between age and mortality and morbidity of patients diagnosed with breast cancer: a retrospective clinical study(2023) Dal, Mehmet Burak; Temiz, MuhyittinObjective: Breast cancer, the most common malignancy among women, is a universally challenging health problem. It is a known fact that the incidence of breast cancer increases with age. In addition, mortality and morbidity increase with age. For now, it does not seem possible to reduce the incidence of breast cancer but it is possible to limit deaths caused by it. Patients are encouraged to get early diag- nosis and age-appropriate screening tests. Because regular screening and early diagnosis are very important in improving breast cancer outcomes. Factors such as age, hormonal status and genetics are associated with the incidence of breast cancer. In this study, we aimed to contribute to the literature by examining age-related mortality and morbidity of breast cancer. Method: This study was carried out at a University Hospital. The sample consisted of 214 women between 01.09.2018/01.09.2022 diagno- sed with breast cancer, aged 30 to 80 years. Results: The mean age of women was 51.9 ± 7.6 years, with 52.8% being <50 years. Breast-conserving surgery was performed on 56.5% of the total participants (n=121). In our series, deaths due to breast cancer are less than 1% under the age of 50 and over 3% in those over the age of 50. Conclusion: Education campaigns should focus on increasing breast cancer awareness among young women, highlighting the importance of early detection and regular screenings. Each patient should receive a tailored treatment plan that considers their age, tumor characte- ristics, fertility preservation preferences, and long-term health goals.Öğe Intestinal-type adenocarcinoma of the sinonasal mucosa: a rare case report(2023) Kuzuluk, Didar Gürsoy; Uysal, Süleyman; Özler, Gül SoyluIntestinal-type adenocarcinoma is the most commonly seen adenocarcinoma of the sinonasal region following adenoid cystic carcinoma. They are aggressive tumors that are generally diagnosed in the advanced stage. Histopathological subtype is an important prognostic indicator. In this report, we have presented a case we diagnosed as intestinal-type adenocarcinoma with right nasal cavity localization.Öğe Can venous blood gas be used instead of arterial blood gas in emergency department?(2023) Erdogan, Yakup Kadri; Karakus, AliObjective: In our study, we aimed to evaluate the usability of venous blood gas (VBG) in substitution for arterial blood gas (ABG). Methods: In this study, 110 patients with respiratory complaints, who were brought intubated were evaluated prospectively. Arterial and venous blood gases were taken simultaneously shortly before the initiation of oxygen therapy in the emergency department. PH, pO2, pCO2, SaO2, HCO3, lactate (Lac) and BEecf values were recorded. Results: Of the 110 patients included in the study, 75 were male (68.2%), 35 were female (31.8%), and they had a mean age of 53.7 ± 23.1 years. A strong positive correlation between PH, PCO2, HCO3-, BEecf, Lac values (p=0.001) and positive correlation between PO2 and SaO2 values (p= 0.002) were detected. Conclusion: We can conclude that venous blood gas be used in substitution for arterial blood gas in patients who are presented to emergency service and it may reduce the need for arterial blood gas sampling.Öğe The frequency and associated factors of infusion-related reactions to rituximab for patients with rheumatoid arthritis(2023) Pekdiker, MeteObjectives: Rituximab is an effective biological agent for treating patients with rheumatoid arthritis (RA). Rheumatologists can avoid rituximab therapy because of infusion-related reactions (IRR). There is a lack of data about rituximab-related IRR, especially in rituximab-naïve patients with RA; therefore, we aimed to determine the frequency and associated factors of rituximab-related IRR in these patients. Methods: Baseline demographic, laboratory, and treatment data were noted. One course of rituximab was used in two infusions to 95 rituximab-naïve patients with RA. Standardized premedication was administered before infusions. Rates, severity, and management of IRR were recorded. Efficacy and infections were also noted if there were. Results: Ninety-four of 95 patients completed the rituximab course successfully. We observed a total of 23 IRRs in 20 patients. The frequency of IRR was 12.1%, and serious IRR was 0.52%. Grade 1-2-3 IRRs had a rate of 52.2%, 30.4%, and 17.4%, respectively; grade 4 or 5 IRR wasn’t detected. Age <60 years, anti-CCP <200U/ml and absence of biologic agent use before rituximab was significantly higher in patients with IRR than without IRR (p=0.01, p=0.002, p=0.01 respectively). We found out that if only the disease age is above 60 months, it is protective against IRR as per the results of multivariate model analysis. Conclusion: Results supported that rituximab is a safe biological agent option for patients with RA at secondary central hospitals. Identified risk factors of IRR need to be corroborated in larger studies for safer rituximab therapy.Öğe A rare malignity observed in the appearance of angiomyolipoma; tubulocystic renal cell carcinoma after partial nephrectomy(2023) Ördek, Eser; Albayrak, İbrahim Halil; Karadeniz, Muhammed Nur; Katı, BülentCystic neoplasms of the kidney are quite rare. Because they contain various differential diagnoses and their radiological features are not specific, their diagnosis is very difficult except for histopathological data. Usually, they can be confused radiologically with benign cysts of the kidney or angiomyolipoma. Radical or partial nephrectomy is the most commonly preferred curative treatment method when it shows features like rapidly growing or malignancy. Histopathological examination is required for definitive diagnosis. In this article, we aimed to present a rare case of tubulocystic renal cell carcinoma after partial nephrectomy in our clinic, who was followed up in another center for years with the pre-diagnosis of angiomyolipoma, in the light of the literature.Öğe Monocyte eosinophil ratio and red blood cell distribution width in the diagnosis of asthma(2023) Koç, İbrahim; Doğan, SerdarObjective: Bronchial asthma is often associated with chronic airway inflammation and airway hyperresponsiveness in which many cells and mediators are involved. Pulmonary function tests (PFTs) are used in the diagnosis of the disease. Yet PFTs are not available in every healthcare institution or some of the patients cannot cooperate with the procedure. The aim of this study was to determine whether mean platelet volume (MPV), platelet distribution width (PDW), monocyte lymphocyte ratio (MLR), monocyte eosinophil ratio (MER), and platelet lymphocyte ratio (PLR) can be used in the diagnosis of bronchial asthma. Method: Two hundred and twelve patients who were diagnosed with bronchial asthma according to the Global Initiative for Asthma (GINA) criteria and 187 patients who were deemed not to have asthma were included in the study. Two patient groups were compared by examining the hemogram parameters at the time of diagnosis or exclusion of asthma. Results: The levels of MPV, neutrophil-lymphocyte ratio (NLR), and PLR were significantly lower in the Asthma group (p
