Protective effects of caffeic acid phenethyl ester on dose-dependent intoxication of rats with paraquat
dc.contributor.author | Silfeler, Ibrahim | |
dc.contributor.author | Alp, Harun | |
dc.contributor.author | Ozgur, Tumay | |
dc.contributor.author | Evlioglu, Osman | |
dc.contributor.author | Celik, Murat | |
dc.contributor.author | Er, Metin | |
dc.contributor.author | Yilmaz, Gulsah | |
dc.date.accessioned | 2024-09-18T20:06:21Z | |
dc.date.available | 2024-09-18T20:06:21Z | |
dc.date.issued | 2015 | |
dc.department | Hatay Mustafa Kemal Üniversitesi | en_US |
dc.description.abstract | Purpose: Paraquat (PQ; 1,1'dimethyl-bipyridilium 4,4'-dichloride), which is used extensively throughout the world, is highly toxic to humans. We aimed to investigate the protective effects of different doses of caffeic acid phenethyl ester (CAPE) on PQ-intoxicated rats. Materials and methods: A total of 80 rats were divided into the following eight groups, comprising 10 rats in each group: group 1: control; group 2: administered with CAPE (10 mu mol/kg); group 3: administered with 15 mg/kg PQ (PQ 15 group); group 4: administered with 30 mg/kg PQ (PQ30 group); group 5: administered with 45 mg/kg PQ (PQ45 group); group 6: administered with 15 mg/kg PQ CAPE; group 7: administered with 30 mg/kg PQ + CAPE and group 8: administered with 45 mg/kg PQ + CAPE. Both PQ and CAPE were injected intraperitoneally. Pancreatic tissue was examined with both haematoxylin and eosin and immunochemical staining. Results: The ratio of the immunohistochemical staining area to the total pancreatic area of the beta cells revealed that statistically significant differences were observed only between the PQ and PQ + CAPE groups (p < 0.05). Discussion: The evaluation of the data suggests that CAPE can be used to prevent acute effects of PQ intoxication. | en_US |
dc.identifier.doi | 10.1177/0748233713484658 | |
dc.identifier.endpage | 1007 | en_US |
dc.identifier.issn | 0748-2337 | |
dc.identifier.issn | 1477-0393 | |
dc.identifier.issue | 11 | en_US |
dc.identifier.pmid | 23589406 | en_US |
dc.identifier.scopus | 2-s2.0-84945124774 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 1000 | en_US |
dc.identifier.uri | https://doi.org/10.1177/0748233713484658 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12483/8476 | |
dc.identifier.volume | 31 | en_US |
dc.identifier.wos | WOS:000363351400005 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Sage Publications Inc | en_US |
dc.relation.ispartof | Toxicology and Industrial Health | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Caffeic acid phenethyl ester | en_US |
dc.subject | pancreas | en_US |
dc.subject | paraquat | en_US |
dc.title | Protective effects of caffeic acid phenethyl ester on dose-dependent intoxication of rats with paraquat | en_US |
dc.type | Article | en_US |
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