In vitro investigation of antimicrobial effects, nanohardness, and cytotoxicity of different glass ionomer restorative materials in dentistry

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dc.contributor.authorCosgun, A.
dc.contributor.authorBolgul, B.
dc.contributor.authorDuran, N.
dc.date.accessioned2024-09-18T19:54:32Z
dc.date.available2024-09-18T19:54:32Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAims: The aim of this in vitro study was to investigate the antimicrobial effects, nanohardness, and cytotoxicity of different glass-ionomer restorative materials in dentistry. Materials and Methods: The following glass-ionomer restorative materials were used in our study: Argion (VOCO, Germany), Zirconomer (Shofu Inc., Japan), EQUIA Forte (GC, Japan), Fuji II LC capsule (GC, Japan), and Fuji IX GP capsule (GC, Japan). For the cytotoxicity test, a cell culture without release liquids was used as the control group. Microdilution and a disk diffusion test were used to measure the antimicrobial activity. The MTT (3- [4,5-dimethylthiazol-2-yl] -2,5-diphenyltetrazolium bromide) assay was used to evaluate cytotoxicity. Nanohardness was measured using a nanoindenter device. Results: Our study determined that all restorative materials used in this study inhibited bacterial growth in cultures containing 1 x 10(2) cfu/ml of the bacterial concentrations (Lactobacillus casei and Streptococcus mutans) and that all restorative materials inhibited fungal growth in the cultures containing <1 x 10(2) cfu/ml of the fungal strains (Candida albicans). IC50 values obtained for the cytotoxicity test were analyzed using the Chi-square test. After a 72-h incubation period, Zirconomer, EQUIA Forte, Fuji IX GP capsule, and Fuji II LG capsule showed statistically significant lower cell viability values. (P < 0.05). The Kruskal-Wallis analysis was performed on the values obtained from the nanohardness test; the differences between the groups were found to be significant (P < 0.05). Conclusions: All materials tested showed low antimicrobial activity, and the antifungal activity of these materials was found to be lower than their antimicrobial activity. Only Argion showed non-cytotoxic effect. Beginning with the group with the highest nanohardness values and ending with the lowest, the groups are ranked in the following order: Fuji II LC capsule, EQUIA Forte, Argion, Fuji IX GP capsule, and Zirconomer.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Projects Unit [17.U.003]en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Projects Unit project number 17.U.003.en_US
dc.identifier.doi10.4103/njcp.njcp_429_18
dc.identifier.endpage431en_US
dc.identifier.issn1119-3077
dc.identifier.issue3en_US
dc.identifier.pmid30837434en_US
dc.identifier.scopus2-s2.0-85062621567en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage422en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_429_18
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7787
dc.identifier.volume22en_US
dc.identifier.wosWOS:000460891100022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectcytotoxicityen_US
dc.subjectglass-ionomer cementen_US
dc.subjectnanohardnessen_US
dc.titleIn vitro investigation of antimicrobial effects, nanohardness, and cytotoxicity of different glass ionomer restorative materials in dentistryen_US
dc.typeArticleen_US

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