The effects of nitrous oxide on vascular endothelial growth factor (VEGF) and its soluble receptor 1 (VEGFR1) in patient undergoing urological surgery

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dc.authoridozkocak turan, isil/0000-0002-0405-0107
dc.contributor.authorHakimoglu, Yasemin
dc.contributor.authorCan, Murat
dc.contributor.authorHakimoglu, Sedat
dc.contributor.authorMungan, Ayca Gorkem
dc.contributor.authorAcikgoz, Sereften
dc.contributor.authorYildirim, Nuran Cikcikoglu
dc.contributor.authorMungan, Necmettin Aydin
dc.date.accessioned2024-09-18T20:52:45Z
dc.date.available2024-09-18T20:52:45Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Anesthesia and surgical intervention, leads to the development of systemic inflammatory response. The severity of the inflammatory response depends on the pharmacological effects of anesthetic agents and duration of anesthesia. Objective of the study was to investigate the effect of nitrous oxide on VEGF and VEGFR1 levels in patients undergoing surgery. Methods: Forty-four patients undergoing elective urological surgery were included in the study. Anesthesia maintenance was provided with 1-2 MAC sevoflurane, O-2 50%, N2O 50% in 4L/m transporter gase for group 1 (n = 22) and 1-2 MAC sevoflurane, O-2 50%, air 50% in 4L/m transporter gase for group 2 (n = 22) Venous blood samples for the measurement of VEGF and VEGFR1 were taken before the induction of anaesthesia, 60 minutes of anesthesia induction, at the end of anaesthesia and 24 hours after operation. In statistical analysis Bonferroni test and analysis of variance at the repeated measures were used Results: In the postoperative period serum VEGF levels had decreased significantly in both group whereas VEGFR1 did not show a significant change. Conclusions: Nitrous oxide showed significant effect on angiogenic parameters. Further detailed studies are required to evaluate the effect of nitrous oxide.en_US
dc.identifier.endpage49en_US
dc.identifier.issn1682-024X
dc.identifier.issue1en_US
dc.identifier.pmid24639829en_US
dc.identifier.scopus2-s2.0-84890475580en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11375
dc.identifier.volume30en_US
dc.identifier.wosWOS:000332130600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNitrous oxideen_US
dc.subjectVEGFen_US
dc.subjectVEGFR1en_US
dc.subjectUrological Surgeryen_US
dc.titleThe effects of nitrous oxide on vascular endothelial growth factor (VEGF) and its soluble receptor 1 (VEGFR1) in patient undergoing urological surgeryen_US
dc.typeArticleen_US

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