The relationship between phthalates and obesity: serum and urine concentrations of phthalates

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dc.authoridUstun, Ihsan/0000-0002-5848-1586
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.authoridSungur, Sana/0000-0001-7370-8972
dc.contributor.authorOktar, Suleyman
dc.contributor.authorSungur, Sana
dc.contributor.authorOkur, Ramazan
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorUstun, Ihsan
dc.contributor.authorGokce, Cumali
dc.date.accessioned2024-09-18T20:54:14Z
dc.date.available2024-09-18T20:54:14Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: A limited number of human and animal studies suggest that a relationship exists between phthalates and obesity, although this is not supported by all research. The purpose of this study was to investigate the relationship between Body Mass Index (BMI) and the levels of phthalates in human blood and urine samples. METHODS: Sixty-four overweight or 132 obese individuals (total=196) of different ages (min-max, 17-62; mean SD, 42.07 +/- 11.3) and genders (F:M 97:99) enrolled in the study. BMI and waist circumference were measured to diagnose obesity. Venous blood samples were taken after overnight fasting. To compare the urine phthalates among participants, single spot urine (at least 10 mL) was collected from the subject after blood samples were taken. Urine and blood phthalate concentrations were measured using gas chromatography. RESULTS: Total blood/urinary phthalate levels significantly increased in proportion to the degree of obesity. There was a high correlation between the level of total phthalates in serum and BMI (p=0.697, P<0.001), and between total urinary phthalate levels and BMI (p=0.707, P<0.001). CONCLUSIONS: This is the first study to have shown that both blood and urinary phthalates increased in proportion to BMI. The results show a strong association between obesity and phthalates.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [111S307]; TUBITAKen_US
dc.description.sponsorshipThis research (111S307) was supported by the Scientific and Technological Research Council of Turkey (TUBITAK). The authors would like to thank the TUBITAK for the financial support provided.en_US
dc.identifier.doi10.23736/S0391-1977.16.02295-1
dc.identifier.endpage52en_US
dc.identifier.issn0391-1977
dc.identifier.issn1827-1634
dc.identifier.issue1en_US
dc.identifier.pmid26006700en_US
dc.identifier.scopus2-s2.0-85014454490en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.23736/S0391-1977.16.02295-1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11691
dc.identifier.volume42en_US
dc.identifier.wosWOS:000397362700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Endocrinologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhthalic aciden_US
dc.subjectBody Mass Indexen_US
dc.subjectWaist circumferenceen_US
dc.subjectObesityen_US
dc.titleThe relationship between phthalates and obesity: serum and urine concentrations of phthalatesen_US
dc.typeArticleen_US

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