Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats

Basit Öğe Kaydı
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridOGUZ, Prof. Dr. Halis/0000-0002-9236-0630
dc.contributor.authorCicekler, Murat Ali
dc.contributor.authorOguz, Halis
dc.contributor.authorCorum, Orhan
dc.date.accessioned2024-09-18T20:26:50Z
dc.date.available2024-09-18T20:26:50Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Antibiotics and bronchodilator drugs can be used together in respiratory distress caused by bacterial infections. Levofloxacin (LVX) and Salbutamol (SLB) can be used simultaneously in respiratory distress. However, there have been no investigations on how the concurrent use of SLB can affect the pharmacokinetics of LVX in rats.Objective The purpose of this study was to investigate the influence of SLB on the plasma and lung pharmacokinetics of LVX in rats.Methods A total of 132 rats were randomly assigned to two groups: LVX (n=66) and LVX+SLB (n=66). LVX (intraperitoneal) and SLB (oral) were administered to rats at doses of 50 and 3 mg/kg, respectively. The concentrations of LVX in the plasma and lungs were determined through the utilization of high-performance liquid chromatography along with UV. Pharmacokinetic parameters were assessed by non-compartmental analysis.Results The area under the curve from 0 to 16 h (AUC0-16), terminal elimination half-life, volume of distribution, total body clearance, and peak concentration of LVX in the plasma were 42.57 h*mu g/mL, 2.32 h, 3.91 L/kg, 1.17 L/h/kg, and 23.96 mu g/mL, respectively. There were no alterations observed in the plasma and lung pharmacokinetic parameters of LVX when co-administered with SLB. The AUC0-16 lung/AUC0-16 plasma ratios of LVX were 1.60 and 1.39 after administration alone and co-administration with SLB, respectively.Conclusion The concentration of LVX in lung tissue was higher than that in plasma. SLB administration to rats did not affect the plasma and lung pharmacokinetics and lung penetration ratio of LVX. There is a need to reveal the change in the pharmacokinetics of LVX after multiple administration of both drugs and after administration of SLB by different routes.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Selcuk, Turkiye [19202082]en_US
dc.description.sponsorshipThis study was summarized from a PhD thesis and supported by The Coordination of Scientific Research Projects, University of Selcuk, Turkiye (Grant no. 19202082).en_US
dc.identifier.doi10.2174/0113892002314136240816094609
dc.identifier.issn1389-2002
dc.identifier.issn1875-5453
dc.identifier.pmid39171585en_US
dc.identifier.urihttps://doi.org/10.2174/0113892002314136240816094609
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10556
dc.identifier.wosWOS:001307416100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Drug Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHPLCen_US
dc.subjectlevofloxacinen_US
dc.subjectoptical L-isomeren_US
dc.subjectpharmacokineticsen_US
dc.subjectsalbutamolen_US
dc.subjectliquid chromatographyen_US
dc.titleEffect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu