Effects of Venlafaxine and Escitalopram Treatments on NMDA Receptors in the Rat Depression Model

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dc.authoridcumhur cure, medine/0000-0001-9253-6459
dc.contributor.authorYilmaz, Nigar
dc.contributor.authorDemirdas, Arif
dc.contributor.authorYilmaz, Mustafa
dc.contributor.authorSutcu, Recep
dc.contributor.authorKirbas, Aynur
dc.contributor.authorCure, Medine Cumhur
dc.contributor.authorEren, Ibrahim
dc.date.accessioned2024-09-18T20:15:05Z
dc.date.available2024-09-18T20:15:05Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractDepression may relate to neurocognitive impairment that results from alteration of N-methyl-d-aspartate receptor (NMDAR) levels. Venlafaxine and escitalopram are two drugs commonly used to treat depression. The drugs may affect expression of NMDARs, which mediate learning and memory formation. The aim of the study was to examine whether the effects of venlafaxine and escitalopram treatments are associated with NMDARs in a rat model of depression. Forty male Wistar albino rats were randomly divided into four groups (n = 10) as follows: control group, chronic mild stress group (CMS), venlafaxine (20 mg/kg body weight per day) + CMS, and escitalopram (10 mg/kg body weight per day) + CMS. After induction of depression, a decrease in the concentration of NR2B was observed; venlafaxine treatment prevented the reduction of NR2B expression. Escitalopram treatment did not effect the reduced levels of NR2B resulting from depression. There was no significant difference in NR2A concentration among groups. The present data support the notion that venlafaxine plays a role in maintaining NR2B receptor in experimental depression. It may be possible that treatment with escitalopram has no effect on NMDARs in experimental depression.en_US
dc.identifier.doi10.1007/s00232-011-9385-3
dc.identifier.endpage151en_US
dc.identifier.issn0022-2631
dc.identifier.issn1432-1424
dc.identifier.issue3en_US
dc.identifier.pmid21755298en_US
dc.identifier.scopus2-s2.0-79961167037en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1007/s00232-011-9385-3
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9442
dc.identifier.volume242en_US
dc.identifier.wosWOS:000293292900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Membrane Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDepressionen_US
dc.subjectEscitalopramen_US
dc.subjectMemoryen_US
dc.subjectNMDA receptorsen_US
dc.subjectVenlafaxineen_US
dc.titleEffects of Venlafaxine and Escitalopram Treatments on NMDA Receptors in the Rat Depression Modelen_US
dc.typeArticleen_US

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