Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model

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dc.contributor.authorObay, Basra Deniz
dc.contributor.authorTasdemir, Ezel
dc.contributor.authorTumer, Cemil
dc.contributor.authorBilgin, Hakki Murat
dc.contributor.authorAtmaca, Mukadder
dc.date.accessioned2024-09-18T20:25:23Z
dc.date.available2024-09-18T20:25:23Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIt has been suggested that free oxygen radicals play a role in the genesis of epilepsy and in post-seizure neuronal death. The aim of this study was to investigate the dose dependent effect of ghrelin on pentylenetetrazole (PTZ)-induced oxidative stress in a rat seizure model. For this purpose, the ghrelin groups were treated with intraperitoneal injections of ghrelin at doses of 20, 40, 60 and 80 [mu g/kg before the PTZ injection. Superoxide dismutase (SOD) and catalase (CAT) activities, and reduced glutathione (GSH) and thiobarbituric acid-reactive substance (TBARS) levels were measured in erythrocytes, liver and brain tissue. TBARS, the indicator of lipid peroxidation, was significantly increased in erythrocytes, liver and brain tissue, while antioxidant enzyme activities and glutathione levels were significantly decreased in PTZ injected rats. Ghrelin pretreatment prevented lipid peroxidation and the reduction in antioxidant enzyme activities and GSH levels against PTZ-induced oxidative stress in a dose dependent manner. The present data indicates that PTZ at a convulsive dose induces an oxidative stress response by depleting the antioxidant defense systems and increasing lipid peroxidation in the erythrocytes, liver and brain of rats. Ghrelin pretreatment diminished oxidative stress and prevented the decrease in antioxidant enzyme activities, and thus may reduce neuronal death in the brain during seizures. However, further studies are needed in order to confirm our hypothesis. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.peptides.2007.11.020
dc.identifier.endpage455en_US
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.issue3en_US
dc.identifier.pmid18215442en_US
dc.identifier.scopus2-s2.0-39649099593en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage448en_US
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2007.11.020
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10272
dc.identifier.volume29en_US
dc.identifier.wosWOS:000254912600017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPeptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectghrelinen_US
dc.subjectepilepsyen_US
dc.subjectbrainen_US
dc.subjectliveren_US
dc.subjectpentylenetetrazoleen_US
dc.subjectoxidative stressen_US
dc.titleDose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure modelen_US
dc.typeArticleen_US

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